The purpose of this document is to provide updated, evidence-based recommendations for the prevention of cardiovascular toxicity associated with anticancer therapy (anthracyclines, HER2-targeted therapy, tyrosine kinase inhibitors, anti-VEGF agents, fluoropyrimidines, and immune checkpoint inhibitors). The consensus covers risk stratification, screening and monitoring (biomarkers and imaging), pharmacological and non-pharmacological cardioprotection, and patient management algorithms for the detection of subclinical and clinically significant damage to the cardiovascular system. The recommendations are structured by recommendation classes (I, IIa, IIb, III) and levels of evidence (A, B, C), and are adapted for Russian and Eurasian clinical practice.

Acute pulmonary embolism (PE) is a life-threatening pathology that potentially requires a wide range of diagnostic, therapeutic, and surgical interventions. Due to the complexity of differential diagnosis and clinical decision-making, as well as the extensive development of modern therapeutic and diagnostic methods for PE, a network of specialized expert-level PE centers has been established internationally. Such facilities allow concentrating qualified medical personnel and high-tech equipment to improve the quality of care for PE patients at intermediate-high and high-risk and to establish a scientific and educational base for future research and the updating of clinical guidelines. The implementation of PE centers can reduce in-hospital mortality and the duration of hospital and intensive care unit stay.

Aim    Analysis of literature on the effect of telemedicine technologies on the adherence of patients with chronic heart failure (CHF) to therapy at the outpatient stage of treatment.
Material and methods    Publications were searched for in PubMed, Web of Science, Scopus, CyberLeninka, and Google Scholar using the key terms "telemedicine technologies," "remote monitoring," "commitment to treatment," "mobile applications in treatment," "telemedicine," and "telemonitoring." Reports were selected (January 2015-January 2025) independently by two researchers who reached a consensus. Based on the selection of literature sources, four studies that met the search criteria were included in the meta-analysis. The analysis was performed with the Review Manager 5.4.1 and Comprehensive Meta-Analysis 3.0 software using the fixed-effects model (inverse variance method). The results were visualized using a forest plot. Heterogeneity assessment included the Q-test and the I2 index (criterion: <75%). Statistical significance was defined at p<0.05. The risk of bias was analyzed across 5 domains: randomization, protocol deviations, missing data, measurement, and results reporting.
Results    The overall adherence rate in the reviewed studies was 64.8% (79/122 patients) in the telemonitoring group and 59.2% (74/125 patients) in the standard observation group, for a total of 61.9% (153/247 patients). Thus, the relative risk of treatment adherence was 1.10 (95% confidence interval (CI) 0.91-1.33; p=0.33). When assessing the homogeneity of the studies with the Pearson’s chi-square test, a statistically non-significant result was obtained (Pearson’s chi-square 2.74 with a degree of freedom of 2, p=0.25), and the heterogeneity index I2=27%, which determines the low heterogeneity of the studies. To identify systematic errors in the studies that used telemonitoring and the standard approach, funnel plot data were accounted for, which indicated an asymmetric distribution of data.
Conclusion    Telemonitoring with mobile apps and wearable devices is beneficial for patient adherence to treatment. Active implementation of these technologies is required to improve the monitoring of the use of prescribed therapy by patients with CHF.

Aim    To determine factors associated with an increased risk of thrombotic complications during antiplatelet therapy in patients with acute myocardial infarction (AMI) based on a study of the parameters of hemostasis functional activity, as well as the proteomic composition of blood plasma and platelets.
Material and methods    A single-center prospective clinical study assessed hemostasis parameters and quantified the plasma and platelet proteome before and after dual antiplatelet therapy (DAPT) in 98 AMI patients. Clinical data on thrombotic complications that occurred during the follow-up period were collected for 12 months after the inclusion into the study. A statistical analysis of the collected data was performed, and the proteins were identified whose concentrations were associated with an increased risk of late thrombotic complications.
Results    The comparative analysis of patient groups with and without thrombotic complications revealed statistically significant differences in the concentrations of several proteins. The univariate regression analysis identified proteins associated with an increased risk of thrombotic complications in the long term. Statistically significant factors with a 95% confidence interval different from 0 were the concentrations of platelet proteins, including von Willebrand factor, complement component C8 β-chain, and cation-independent mannose-6 phosphate receptor.
Conclusion    The study identified proteins whose concentrations were associated with an increased risk of thrombotic complications in AMI patients taking DAPT. Before implementing these findings in clinical practice, a randomized prospective study should be performed for validation of the study results.

Aim        To study the immediate outcome of an interventional method for the treatment of mitral regurgitation (MR) using the MitraClip system (Abbott Vascular) in the context of the etiological factor.

Material and methods         

This was a prospective, single-center study. A total of 89 patients treated in 2023-2024 were included in the analysis. Most patients belonged to an older age group (67.6 ± 9.3 years) where males predominated (57.3%). Echocardiography (EchoCG) was performed on a Philips EPIQ CVx ultrasound system using X5-1 and X8 t transducers. The severity of MR was assessed by multiparametric EchoCG. Quantitative measurements were performed in accordance with current Guidelines of the American Society of Echocardiography and the European Association of Cardiovascular Imaging (ASE and EACVI, 2015).

Results    In 19.1% of cases, the cause of MR was mitral valve leaflet chordae prolapse or rupture (primary mitral regurgitation (PMR) group, group 1). In 80.9% of cases, MR was secondary: in 29.2%, MR was atrial functional mitral regurgitation (a-FMR, group 2) and in 51.7%, MR was ventricular FMR (v-FMR, group 3). Comparative analysis of EchoCG data showed that with a comparable MR degree, the left ventricular systolic function was significantly lower in the v-FMR group than in the PMR group, and was also inferior to that in the a-FMR group (42.7±10.2% vs. 53.5±8.5 and 49.2±10.7%, respectively; p_1-3<0.001, p_2-3=0.029). The effectiveness of the procedure evident in a reduction of the MR degree was achieved in 93.2% of patients (grade <1 in 64% of them). The maximum reduction in MR to grade I and less was noted in the v-FMR group (71.7%); this proportion was higher compared to other groups (a-FMR, 57.7%; PMR, 52.9%). All groups had improvements in symptoms and in the NYHA chronic heart failure (CHF) functional class (FC). The v-FMR group achieved a more pronounced symptomatic improvement and a reduction in FC (95.7% of patients with FC II).

Conclusion            Transcatheter edge-to-edge mitral valve reconstructive procedures using the MitraClip system achieved significant immediate reductions in MR, regardless of its etiology. Long-term follow-up is essential to assess the result sustainability.

Aim        To study morphological features of lung tissue and pulmonary vessels in patients with pulmonary hypertension (PH) associated with acquired mitral valve (MV) defects, with indications for surgical treatment.

Material and methods          This cross-sectional study included 105 patients with acquired MV defect of non-infectious origin (median age 60.0 [51.0; 66.0] years, 55.24% men) who underwent corrective surgery under cardiopulmonary bypass between 2024 through March 2025. PH was verified by right heart catheterization before defect correction. In 26 patients with MV defect and PH and 12 patients without PH, intraoperative lung tissue puncture biopsy samples were collected to assess changes in the lung parenchyma and microvasculature.

Results    In patients with MV defect and PH, the condition of arterioles was characterized by a larger area of intimal hyperplasia and predominantly the presence of thrombosis (34.6%). In patients with MV defect without PH, partial thrombosis of arterioles was more often found (41.66%), and plethoric arterioles were observed in 41.66%. During morphometry of pulmonary vessels, it was noted that the a calculated systolic pressure in the pulmonary artery of >38 mm Hg according to preoperative echocardiography (EchoCG) had a moderate inverse correlation with the area of the vascular wall (Kendall's rank correlation coefficient tau (τ) = -0.34; p=0.01) and a moderate direct association with the greatest thickness at the site of arteriolar intimal hyperplasia (τ = 0.39; p = 0.04). A moderate inverse correlation was found between the systolic excursion of the tricuspid valve annulus (1.7 cm or more) and the greatest thickness at the site of arteriolar intimal hyperplasia (τ= –0.47; p=0.04). MV stenosis was associated with the presence of thrombosed capillaries (odds ratio (OR) 8.75; 95% confidence interval (CI) 1.1-69.5; p=0.029) and focal interstitial fibrosis (OR 10.66; 95% CI 0.89-126.78; p=0.046). The presence of mitral stenosis had a moderate correlation with perivascular fibrosis (τ=0.41; p=0.005). A body mass index of >25 kg/m² was associated with reduced odds of arteriolar media thickening (OR 0.15; 95% CI 0.02-1.01; p=0.03).

Conclusion            The severity of PH and right ventricular dysfunction, as determined by EchoCG before MV defect correction, may reflect morphometric changes in the pulmonary vessels. The nature of MV lesion, based on its stenosis type, is associated with a more than 8-fold increase in the odds of thrombosed capillaries and a 10-fold increase in the odds of focal interstitial fibrosis. Being overweight or obese was associated with an 85% reduction in the odds of arteriolar media thickening, as determined by pulmonary vascular morphometry.

Aim    To study the pharmacokinetics and safety and to prove the bioequivalence of Akrivario* (valsartan + sacubitril) film-coated tablets, at two dosages, 200 mg and 100 mg, compared to Uperio** (valsartan + sacubitril) film-coated tablets, at similar dosages, 200 mg and 100 mg (Studies 1 and 2, respectively), after oral administration to fasted healthy volunteers.
Material and methods    Two four-period, crossover-design bioequivalence studies were conducted. In each study, fasted healthy volunteers (Study 1: n=60; Study 2: n=59) received a single dose of the drugs. The interval between drug administrations was 7 days. Analyte concentrations in blood samples were measured by validated high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Pharmacokinetic parameters were determined for both valsartan and sacubitril in both studies.
Results    The 90% confidence intervals for the Ln-transformed ratios of all assessed pharmacokinetic parameters (Cmax and AUC0-t for valsartan and sacubitril) were in the range of 80-125%. Both study drugs were well tolerated; all adverse events (AEs) were mild and did not require additional therapy. No clinically significant AEs were observed during the study.
Conclusion: The study demonstrated bioequivalence of Akrivario (valsartan + sacubitril) to the reference drug Uperio (valsartan + sacubitril).

Objective        This study aimed to investigate the role of the triglyceride to high-density lipoprotein cholesterol (TG / HDL-C) ratio for the prediction of major adverse cardiovascular events (MACEs) in non-diabetic individuals.
Material and methods    In total 88946 non-diabetic individuals were enrolled in the study. These individuals were divided into four groups according to the TG / HDL-C ratios. The clinical endpoints were composite MACEs and their subtypes, myocardial infarction and stroke. Cox proportional hazards regression models and restricted cubic spline (RCS) analysis were conducted to explore the relationship between the TG / HDL-C ratio and MACEs.
Results    Multivariable Cox proportional hazards analyses showed that a higher TG / HDL-C ratio was associated with an elevated risk of MACEs. Kaplan–Meier survival curve showed that participants in higher quartiles of TG / HDL-C ratio had a higher cumulative incidence of composite MACEs (p<0.0001). In addition, RCS analysis indicated that the TG / HDL-C ratio and composite MACEs followed a non-linear relationship (p<0.0001).
Conclusions    The TG / HDL-C ratio can serve as a prognostic marker of MACEs in non-diabetic individuals.

Background Cardiac arrest is a severe medical emergency with poor prognosis. This study aimed to analyze the clinical characteristics of cardiac arrest patients and explore the key factors influencing their outcomes. Additionally, we applied machine learning methods to evaluate the performance of different models in predicting return of spontaneous circulation (ROSC), with the goal of optimizing strategies for managing cardiac arrest.
Material and methods We comprehensively assessed the demographic characteristics, physiological parameters, and laboratory results of 748 cardiac arrest patients, and compared the differences between the ROSC and non-ROSC groups. We applied LASSO regression analysis to identify the key variables predictive of ROSC. Furthermore, we evaluated the performance of various machine learning models, including GBDT and LGBM, in ROSC prediction, including calibration, decision curve analysis, and ROC curves.
Results Patients in the ROSC group were younger and predominately male. They had more normal blood pressure, temperature, and oxygen saturation, as well as less severe organ dysfunction, LASSO regression analysis identified age, WBC, and lactate as key predictors of ROSC. Among the machine learning models, GBDT and LGBM exhibited the best performance, with superior alibration, decision curve analysis, and ROC curves compared.
Conclusions This study identified key clinical factors influencing the prognosis of cardiac arrest patients, and it identified machine learning models that were superior for predicting ROSC.

Chronic heart failure with preserved ejection fraction (CHFpEF) is a common syndrome that leads to adverse outcomes. The syndrome is quite heterogeneous and, according to multiple clinical, genetic, molecular, proteomic, and other studies, varies significantly depending on the predominant pathophysiological mechanism. Currently, modern research methods, such as those for studying proteome, genome, and epicardial regulation, allow a more precise identification of phenotypes. This review focuses on existing concepts on phenotypes in CHFpEF, specifically, aseptic inflammation, myocardial fibrosis, dysmetabolism, and others. Data were searched using the PubMed search by keywords in the 2010-2025 time range using the following tags: HFpEF, phenotypes, proteome, metabolome, inflammation, fibrosis. Currently, a limited number of drugs is available for the treatment of CHFpEF. Potentially, identifying phenotypes in each individual patient will facilitate personalized therapy, such as anti-inflammatory therapy for those with a predominantly inflammatory component, antifibrotic therapy for those with a fibrotic phenotype, etc.