Биомаркеры воспаления, полученные из подсчета клеток цельной крови, у пациентов с фибрилляцией предсердий

Цель    Это исследование было направлено на оценку возможных ассоциаций между фибрилляцией предсердий (ФП) и гематологическими показателями, такими как соотношение «нейтрофилы/лимфоциты» (NLR), средний объем тромбоцитов (MPV), соотношение «тромбоциты/лимфоциты» (PLR), отношение среднего объема тромбоцитов к их количеству (MPV/PLT), соотношение «нейтрофилы/моноциты» (NMR), соотношение «лимфоциты/моноциты» (LMR), индекс системного иммунного воспаления (SII, произведение количества тромбоцитов и нейтрофилов, разделенное на количество лимфоцитов), и соотношение «моноциты/липопротеины высокой плотности» (MHR), которые можно получить из общего анализа крови .
Материал и методы    Проведено ретроспективное исследование с включением 150 пациентов в возрасте 40-80 лет с диагнозом ФП. Контрольную группу составили 91 человек того же возраста и пола. Оценивали гематологические показатели и маркеры воспаления.
Результаты    В группе с ФП были повышены NLR, PLR, SII, MHR и MPV/PLT, а LMR был снижен. Многофакторный регрессионный анализ показал, что гематологические показатели NLR, SII и MHR являются значимыми, независимыми прогностическими факторами для ФП. ROC-кривые выявили следующие значимые значения чувствительности и специфичности: NLR 75%, 52,3%; LMR 61,3%, 67,3%; SII 67,4%, 64,6%; MHR 100%, 56%.
Заключение    NLR, PLR, LMR, SII, MPV/PLT и MHR могут применяться для раннего прогнозирования развития ФП. Особо подчеркивается, что среди этих маркеров MHR может быть наилучшей независимой переменной, которую можно использовать для прогнозирования ФП.

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