ВАЖНО! Правила приравнивания журналов, входящих в международные базы данных к журналам перечня ВАК.
Ответ на официальный запрос в ВАК журнала Кардиология.

Preview

Kardiologiia

Advanced search

Evaluation of triglyceride-glucose index in coronary slow flow patients

https://doi.org/10.18087/cardio.2023.5.n2296

Abstract

Aim    Triglyceride glucose index (TyG index) is a surrogate marker for insulin resistance. No studies have evaluated the TyG index in patients with coronary slow flow phenomenon (CSFP). We investigated TyG index values in CSFP and evaluated whether it had a predictive value for the diagnosis of CSFP.
Material and Methods    132 CSFP patients and 148 subjects with normal coronary arteries were included in the study. Thrombo­lysis in myocardial infarction frame count (TFC) of each patient was calculated. Demographic, clinical features, information regarding medication use and biochemical variables of the patients were obtained from hospital records.
Results    TyG index of patients with CSFP and normal coronary flow were 9.02 (8.65–9.42) and 8.69 (8.39–9.18), respectively (p<0.001). Mean TFC showed positive correlation with the TyG index, glucose, triglyceride, and hemoglobin concentration (r=0.207, r=0.138, r=0.183, r=0.179 and p<0.001, p=0.020, p=0.002, p=0.003, respectively) and negative correlation with high density lipoprotein-cholesterol (HDL–C) level (r=–0.292, p<0.001). Receiver operating characteristic curve analysis of TyG index demonstrated that the value of 8.68 predicted CSFP curve analysis of TyG index demonstrated that the value of 8.68 predicted CSFP with sensitivity of 74.2 % and specificity of 58.6 %. In multivariate logistic regression analysis, HDL–C, hemoglobin and the TyG index were the independent predictors of CSFP.
Conclusions    Our findings supported the hypothesis that insulin resistance play role in CSFP.

 

About the Authors

Yasin Yuksel
Private Reyap Hospital
Turkey

MD

Cardiology Department, Istanbul, Turkey



Cennet Yildiz
Bakirkoy Dr. Sadi Konuk Training and Research Hospital
Turkey

MD

 Cardiology Department, Istanbul, Turkey



References

1. Alvarez C, Siu H. Coronary Slow-Flow Phenomenon as an Underrecognized and Treatable Source of Chest Pain: Case Series and Literature Review. Journal of Investigative Medicine High Impact Case Reports. 2018;6:232470961878919. DOI: 10.1177/2324709618789194

2. Sanghvi S, Mathur R, Baroopal A, Kumar A. Clinical, demographic, risk factor and angiographic profile of coronary slow flow phenomenon: A single centre experience. Indian Heart Journal. 2018;70(Suppl 3):S290–4. DOI: 10.1016/j.ihj.2018.06.001

3. Chalikias G, Tziakas D. Slow Coronary Flow: Pathophysiology, Clinical Implications, and Therapeutic Management. Angiology. 2021;72(9):808–18. DOI: 10.1177/00033197211004390

4. Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, FunckBrentano C et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal. 2020;41(3):407–77. DOI: 10.1093/eurheartj/ehz425

5. Wybraniec MT, Bańka P, Bochenek T, Roleder T, Mizia-Stec K. Small vessel coronary artery disease: How small can we go with myocardial revascularization? Cardiology Journal. 2021;28(5):767–78. DOI: 10.5603/CJ.a2020.0127

6. Tanriverdi H, Evrengul H, Enli Y, Kuru O, Seleci D, Tanriverdi S et al. Effect of Homocysteine-Induced Oxidative Stress on Endothelial Function in Coronary Slow-Flow. Cardiology. 2007;107(4):313–20. DOI: 10.1159/000099068

7. Sezgin AT, Sigirci A, Barutcu I, Topal E, Sezgin N, Ozdemir R et al. Vascular endothelial function in patients with slow coronary flow. Coronary Artery Disease. 2003;14(2):155–61. DOI: 10.1097/00019501-200304000-00008

8. Pekdemir H, Cin VG, Cicek D, Camsari A, Akkus N, Döven O et al. Slow coronary flow may be a sign o diffuse atherosclerosis. Acta Cardiologica. 2004;59(2):127–33. DOI: 10.2143/AC.59.2.2005166

9. Muniyappa R, Chen H, Montagnani M, Sherman A, Quon MJ. Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling. American Journal of Physiology-Endocrinology and Metabolism. 2020;319(3):E629–46. DOI: 10.1152/ajpendo.00247.2020

10. Metwally YG, Sedrak HK, Shaltout IF. Coronary slow flow in patients with impaired glucose tolerance and insulin resistance. The Egyptian Journal of Internal Medicine. 2020;32(1):20. DOI: 10.1186/s43162-020-00020-1

11. Katsuki A, Sumida Y, Gabazza EC, Murashima S, Furuta M, ArakiSasaki R et al. Homeostasis Model Assessment Is a Reliable Indicator of Insulin Resistance During Follow-up of Patients With Type 2 Diabetes. Diabetes Care. 2001;24(2):362–5. DOI: 10.2337/diacare.24.2.362

12. Akbar MR, Pranata R, Wibowo A, Irvan, Sihite TA, Martha JW. The association between triglyceride-glucose index and major adverse cardiovascular events in patients with acute coronary syndrome – dose–response meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases. 2021;31(11):3024–30. DOI: 10.1016/j.numecd.2021.08.026

13. Huang R, Wang Z, Chen J, Bao X, Xu N, Guo S et al. Prognostic value of triglyceride glucose (TyG) index in patients with acute decompensated heart failure. Cardiovascular Diabetology. 2022;21(1):88. DOI: 10.1186/s12933-022-01507-7

14. Zheng R, Mao Y. Triglyceride and glucose (TyG) index as a predictor of incident hypertension: a 9-year longitudinal population-based study. Lipids in Health and Disease. 2017;16(1):175. DOI: 10.1186/s12944-017-0562-y

15. Hong S, Han K, Park C-Y. The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study. BMC Medicine. 2020;18(1):361. DOI: 10.1186/s12916-020-01824-2

16. Gibson CM, Cannon CP, Daley WL, Dodge JT, Alexander B, Marble SJ et al. TIMI Frame Count: A Quantitative Method of Assessing Coronary Artery Flow. Circulation. 1996;93(5):879–88. DOI: 10.1161/01.CIR.93.5.879

17. Selcuk H, Selcuk MT, Temizhan A, Maden O, Saydam GS, Ulupinar H et al. Decreased plasma concentrations of adiponectin in patients with slow coronary flow. Heart and Vessels. 2009;24(1):1–7. DOI: 10.1007/s00380-008-1074-5

18. Binak E, Gunduz H, Sahin M, Kurtoglu N, Dindar I. The relation between impaired glucose tolerance and slow coronary flow. International Journal of Cardiology. 2006;111(1):142–6. DOI: 10.1016/j.ijcard.2005.09.007

19. Yazici M, Demircan S, Aksakal E, Sahin M, Meriç M, Dursun I et al. Plasma insulin, glucose and lipid levels, and their relations with corrected TIMI frame count in patients with slow coronary flow. Anatolian journal of cardiology. 2003;3(3):222–6. PMID: 12967888

20. Riboldi BP, Luft VC, de Castilhos CD, de Cardoso LO, Schmidt MI, Barreto SM et al. Glucose and triglyceride excursions following a standardized meal in individuals with diabetes: ELSA-Brasil study. Cardiovascular Diabetology. 2015;14(1):21. DOI: 10.1186/s12933-015-0181-8

21. Tripathy D, Almgren P, Tuomi T, Groop L. Contribution of Insulin-Stimulated Glucose Uptake and Basal Hepatic Insulin Sensitivity to Surrogate Measures of Insulin Sensitivity. Diabetes Care. 2004;27(9):2204–10. DOI: 10.2337/diacare.27.9.2204

22. Lee SB, Ahn CW, Lee BK, Kang S, Nam JS, You JH et al. Association between triglyceride glucose index and arterial stiffness in Korean adults. Cardiovascular Diabetology. 2018;17(1):41. DOI: 10.1186/s12933-018-0692-1

23. Irace C, Carallo C, Scavelli FB, De Franceschi MS, Esposito T, Tripolino C et al. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. International Journal of Clinical Practice. 2013;67(7):665–72. DOI: 10.1111/ijcp.12124

24. Seyyed-Mohammadzad MH, Khademvatani K, Gardeshkhah S, Sedokani A. Echocardiographic and laboratory findings in coronary slow flow phenomenon: cross-sectional study and review. BMC Cardiovascular Disorders. 2021;21(1):230. DOI: 10.1186/s12872-021-02044-z

25. Altun I, Akin F, Kose N, Sahin C, Kirli I. Predictors of slow flow in angiographically normal coronary arteries. International Journal of Clinical and Experimental Medicine. 2015;8(8):13762–8. PMID: 26550323

26. Seyyed-Mohammadzad MH, Khademvatani K, Kerachian A, Eskandari R, Rezaei Y. Slow Coronary Flow Phenomenon and Increased Platelet Volume Indices. Korean Circulation Journal. 2014;44(6):400–5. DOI: 10.4070/kcj.2014.44.6.400

27. Kim K-W, Ivanov S, Williams JW. Monocyte Recruitment, Specification, and Function in Atherosclerosis. Cells. 2020;10(1):15. DOI: 10.3390/cells10010015

28. Bonacina F, Pirillo A, Catapano AL, Norata GD. HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases. Cells. 2021;10(5):1061. DOI: 10.3390/cells10051061

29. Huang Q, Zhang F, Chen S, Dong Z, Liu W, Zhou X. Clinical characteristics in patients with coronary slow flow phenomenon: A retrospective study. Medicine. 2021;100(6):e24643. DOI: 10.1097/MD.0000000000024643


Review

For citations:


Yuksel Ya., Yildiz C. Evaluation of triglyceride-glucose index in coronary slow flow patients. Kardiologiia. 2023;63(5):62-67. https://doi.org/10.18087/cardio.2023.5.n2296

Views: 1512


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0022-9040 (Print)
ISSN 2412-5660 (Online)