Iron deficiency in Russia heart failure patients. Observational cross-sectional multicenter study
V. Yu. Mareev,
Yu. L. Begrambekova,
Yu. V. Mareev,
Zh. D. Kobalava,
L. V. Karapetyan,
S. A. Galochkin,
E. R. Kazakhmedov,
A. A. Lapshin,
A. A. Garganeeva,
E. A. Kuzheleva,
A. А. Efremushkina,
E. V. Kiseleva,
O. L. Barbarash,
T. B. Pecherina,
A. S. Galyavich,
Z. M. Galeeva,
L. V. Baleeva,
N. A. Koziolova,
A. S. Veklich,
D. V. Duplyakov,
M. N. Maksimova,
S. S. Yakushin,
E. A. Smirnova,
E. V. Sedykh,
I. I. Shaposhnik,
N. A. Makarova,
A. A. Zemlyanukhina,
V. V. Skibitsky,
A. V. Fendrikova,
A. V. Skibitsky,
N. A. Spiropulos,
E. M. Seredenina,
Ya. A. Orlova,
K. A. Eruslanova,
Yu. V. Kotovskaya,
O. N. Tkacheva,
M. A. Fedin https://doi.org/10.18087/cardio.2022.5.n2083
Abstract
Aim To evaluate the prevalence of iron deficiency (ID) in Russian patients with heart failure (HF).
Material and methods Iron metabolism variables were studied in 498 (198 women, 300 men) patients with HF. Data were evaluated at admission for HF (97 %) or during an outpatient visit (3 %). ID was determined according to the European Society of Cardiology Guidelines.
Results 83.1 % of patients had ID; only 43.5 % of patients with ID had anemia. Patients with ID were older: 70.0 [63.0;79.0] vs. 66.0 years [57.0;75.2] (p=0.009). The number of patients with ID increased in parallel with the increase in HF functional class (FC). Among patients with ID, fewer people were past or current alcohol users (p=0.002), and a greater number of patients had atrial fibrillation (60.1 vs. 45.2 %, p=0.016). A multiple logistic regression showed that more severe HF (HF FC) was associated with a higher incidence of ID detection, whereas past alcohol use was associated with less pronounced ID. An increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) by 100 pg/ml was associated with an increased likelihood of ID (odds ratio, 1.006, 95 % confidence interval: 1.002–1.011, p=0.0152).
Conclusion The incidence rate of HF patients is high in the Russian Federation (83.1 %). Only 43.5 % of these patients had anemia. The prevalence of ID in the study population increased with increases in HF FC and NT-proBNP.
Supporting agencies: No conflict of interest is reported.
About the Authors
V. Yu. Mareev
Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University
Russian Federation
Russian Federation
Chief Researcher Medical Research and Education Center of Moscow State University M.V. Lomonosova,
Moscow, Russia
Yu. L. Begrambekova
Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University
Russian Federation
Russian Federation
Leading Researcher Medical Research and Education Center of Moscow State University M.V. Lomonosova
Moscow, Russia
Yu. V. Mareev
National Medical Research Center for Therapy and Preventive Medicine; Medical Research and Educational Center, Lomonosov Moscow State University
Russian Federation
Russian Federation
Chief Researcher Medical Research and Education Center of Moscow State University M.V. Lomonosova,
Moscow, Russia
Zh. D. Kobalava
People’s Friendship University of Russia; Vinogradov Municipal Clinical Hospital
Russian Federation
Russian Federation
Head of the Department of Internal Medicine and Clinical Pharmacology, Faculty of Advanced Training of Medical Workers
Moscow, Russia
L. V. Karapetyan
People’s Friendship University of Russia; Vinogradov Municipal Clinical Hospital
Russian Federation
Russian Federation
Assistant Professor
Moscow, Russia
S. A. Galochkin
People’s Friendship University of Russia; Vinogradov Municipal Clinical Hospital
Russian Federation
Russian Federation
assistant of the department
Moscow, Russia
E. R. Kazakhmedov
People’s Friendship University of Russia; Vinogradov Municipal Clinical Hospital
Russian Federation
Russian Federation
assistant of the department
Moscow, Russia
A. A. Lapshin
People’s Friendship University of Russia; Vinogradov Municipal Clinical Hospital
Russian Federation
Russian Federation
graduate student
Moscow, Russia
A. A. Garganeeva
Research Institute of Cardiology, Tomsk National Research Medical Center
Russian Federation
Russian Federation
Head of the Department of General Clinical Cardiology and Epidemiology of Cardiovascular Diseases
Tomsk, Russia
E. A. Kuzheleva
Research Institute of Cardiology, Tomsk National Research Medical Center
Russian Federation
Russian Federation
Candidate of Medical Sciences, Researcher, Department of Myocardial Pathology, Cardiology Research Institute, Tomsk National Research Medical center, Russian Academy of Sciences
Tomsk, Russia
A. А. Efremushkina
Altai State Medical University; Altai Territory Cardiological Center
Russian Federation
Russian Federation
Professor
Barnaul, Russia
E. V. Kiseleva
Altai Territory Cardiological Center
Russian Federation
Russian Federation
Head of Rehabilitation Department
Barnaul, Russia
O. L. Barbarash
Research Institute for Complex Problems of Cardiovascular Diseases
Russian Federation
Russian Federation
Director, M.D., Prof.
Kemerovo, Russia
T. B. Pecherina
Research Institute for Complex Problems of Cardiovascular Diseases
Russian Federation
Russian Federation
Kemerovo, Russia
A. S. Galyavich
Kazan State Medical University
Russian Federation
Russian Federation
Head of the Department of Faculty Therapy and Cardiology
Kazan, Russia
Z. M. Galeeva
Kazan State Medical University
Russian Federation
Russian Federation
Kazan, Russia
L. V. Baleeva
Kazan State Medical University
Russian Federation
Russian Federation
Kazan, Russia
N. A. Koziolova
Academician Vagner Perm State Medical University
Russian Federation
Russian Federation
Head of the Department of Propedeutics of Internal Diseases No. 2
Perm, Russia
A. S. Veklich
Academician Vagner Perm State Medical University
Russian Federation
Russian Federation
Perm, Russia
D. V. Duplyakov
Research Institute of Cardiology, Samara State Medical University; Polyakov Samara Regional Clinical Cardiology Dispensary
Russian Federation
Russian Federation
Deputy Chief Physician for Medical Affair
Samara, Russia
M. N. Maksimova
Polyakov Samara Regional Clinical Cardiology Dispensary
Russian Federation
Russian Federation
Samara, Russia
S. S. Yakushin
Academician Pavlov Ryazan State Medical University; Ryazan Regional Clinical Cardiology Dispensary
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of the Department of Hospital Therapy
Ryazan, Russia
E. A. Smirnova
Academician Pavlov Ryazan State Medical University
Russian Federation
Russian Federation
Ryazan, Russia
E. V. Sedykh
Academician Pavlov Ryazan State Medical University
Russian Federation
Russian Federation
Ryazan, Russia
I. I. Shaposhnik
South Ural State Medical University
Russian Federation
Competing Interests:
Russian Federation
Doctor of Medical Sciences, Professor, Head. Department of propaedeutics of internal diseases
Chelyabinsk, Russia
Competing Interests:
N. A. Makarova
South Ural State Medical University
Russian Federation
Russian Federation
Chelyabinsk, Russia
A. A. Zemlyanukhina
Chelyabinsk Municipal Clinical Hospital #1
Russian Federation
Russian Federation
Chelyabinsk, Russia
V. V. Skibitsky
Kuban State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of the Department of Hospital Therapy
Krasnodar, Russia
A. V. Fendrikova
Kuban State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of the Department of Hospital Therapy
Krasnodar, Russia
A. V. Skibitsky
Kuban State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of the Department of Hospital Therapy
Krasnodar, Russia
N. A. Spiropulos
Clinical Hospital for Emergency Care
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of Cardiology Department No. 2
Krasnodar, Russia
E. M. Seredenina
Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University
Russian Federation
Russian Federation
Moscow, Russia
Ya. A. Orlova
Medical Research and Educational Center, Lomonosov Moscow State University; School of Fundamental Medicine, Lomonosov Moscow State University
Russian Federation
Russian Federation
Head of the Department of Age-Associated Diseases Medical Research Center of Moscow State University M.V. Lomonosova
Moscow, Russia
K. A. Eruslanova
Russian Gerintology Research and Clinical Centre
Russian Federation
Russian Federation
MD, MSc, Researcher, Laboratory of cardiovascular agineg, Russian Clinical and Research Center of Gerontology, Pirogov’s Russian National Research Medical University.
Moscow, Russia
Yu. V. Kotovskaya
Russian Gerintology Research and Clinical Centre
Russian Federation
Russian Federation
Professor, MD, PhD, DrMS, Deputy Director of Sience work the Russian Clinical and Research Center of Gerontology, Head of the Laboratory of Cardiovascular Ageing, Pirogov’s Russian National Research Medical University.
Moscow, Russia
O. N. Tkacheva
Russian Gerintology Research and Clinical Centre
Russian Federation
Russian Federation
Professor, MD, PhD, DrMS, Director of the Russian Clinical and Research Center of Gerontology, Pirogov’s Russian National Research Medical University.
Moscow, Russia
M. A. Fedin
Russian Gerintology Research and Clinical Centre; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Physician of the Russian Clinical and Research Center of Gerontology, Pirogov’s Russian National Research Medical University
Moscow, Russia
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For citations:
Mareev V.Yu., Begrambekova Yu.L., Mareev Yu.V., Kobalava Zh.D., Karapetyan L.V., Galochkin S.A., Kazakhmedov E.R., Lapshin A.A., Garganeeva A.A., Kuzheleva E.A., Efremushkina A.А., Kiseleva E.V., Barbarash O.L., Pecherina T.B., Galyavich A.S., Galeeva Z.M., Baleeva L.V., Koziolova N.A., Veklich A.S., Duplyakov D.V., Maksimova M.N., Yakushin S.S., Smirnova E.A., Sedykh E.V., Shaposhnik I.I., Makarova N.A., Zemlyanukhina A.A., Skibitsky V.V., Fendrikova A.V., Skibitsky A.V., Spiropulos N.A., Seredenina E.M., Orlova Ya.A., Eruslanova K.A., Kotovskaya Yu.V., Tkacheva O.N., Fedin M.A. Iron deficiency in Russia heart failure patients. Observational cross-sectional multicenter study. Kardiologiia. 2022;62(5):4-8. https://doi.org/10.18087/cardio.2022.5.n2083
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