Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)
E. I. Tarlovskaya,
A. G. Arutyunov,
A. O. Konradi,
Yu. M. Lopatin,
A. P. Rebrov,
S. N. Tereshchenko,
A. I. Chesnikova,
H. G. Hayrapetyan,
A. P. Babin,
I. G. Bakulin,
N. V. Bakulina,
L. A. Balykova,
A. S. Blagonravova,
M. V. Boldina,
A. R. Vaisberg,
A. S. Galyavich,
V. V. Gomonova,
N. Yu. Grigorieva,
I. V. Gubareva,
I. V. Demko,
A. V. Evzerikhina,
A. V. Zharkov,
U. K. Kamilova,
Z. F. Kim,
T. Yu. Kuznetsova,
N. V. Lareva,
E. V. Makarova,
S. V. Malchikova,
S. V. Nedogoda,
M. M. Petrova,
I. G. Pochinka,
K. V. Protasov,
D. N. Protsenko,
D. Yu. Ruzanau,
S. A. Sayganov,
A. S. Sarybaev,
N. M. Selezneva,
A. B. Sugraliev,
I. V. Fomin,
O. V. Khlynova,
O. Yu. Chizhova,
I. I. Shaposhnik,
D. A. Shсukarev,
A. K. Abdrahmanova,
S. A. Avetisian,
H. G. Avoyan,
K. K. Azarian,
G. T. Aimakhanova,
D. A. Ayipova,
A. Ch. Akunov,
M. K. Alieva,
A. V. Aparkina,
O. R. Aruslanova,
E. Yu. Ashina,
O. Yu. Badina,
O. Yu. Barisheva,
A. S. Batchayeva,
A. M. Bitieva,
I. U. Bikhteyev,
N. A. Borodulina,
M. V. Bragin,
A. M. Budu,
L. A. Burygina,
G. A. Bykova,
K. R. Vagapova,
D. D. Varlamova,
N. N. Vezikova,
E. A. Verbitskaya,
O. E. Vilkova,
E. A. Vinnikova,
V. V. Vustina,
E. A. Gаlova,
V. V. Genkel,
E. I. Gorshenina,
R. V. Gostishev,
E. V. Grigorieva,
E. Yu. Gubareva,
G. M. Dabylova,
A. I. Demchenko,
O. Yu. Dolgikh,
M. Y. Duyshobayev,
D. S. Evdokimov,
K. E. Egorova,
A. N. Ermilova,
A. E. Zheldybayeva,
N. V. Zarechnova,
Yu. D. Zimina,
S. Yu. Ivanova,
E. Yu. Ivanchenko,
M. V. Ilina,
M. V. Kazakovtseva,
E. V. Kazymova,
Yu. S. Kalinina,
N. A. Kamardina,
A. M. Karachenova,
I. A. Karetnikov,
N. A. Karoli,
O. V. Karpov,
M. Kh. Karsiev,
D. S. Кaskaeva,
K. F. Kasymova,
Zh. B. Kerimbekova,
A. Sh. Kerimova,
E. S. Kim,
N. V. Kiseleva,
D. A. Klimenko,
A. V. Klimova,
O. V. Kovalishena,
E. V. Kolmakova,
T. P. Kolchinskaya,
M. I. Kolyadich,
O. V. Kondriakova,
M. P. Konoval ,
D. Yu. Konstantinov,
E. A. Konstantinova,
V. A. Kordukova,
E. V. Koroleva,
A. Yu. Kraposhina,
T. V. Kriukova,
A. S. Kuznetsova,
T. Yu. Kuzmina,
K. V. Kuzmichev,
Ch. K. Kulchoroeva,
T. V. Kuprina,
I. M. Kouranova,
L. V. Kurenkova,
N. Yu. Kurchugina,
N. A. Kushubakova,
V. I. Levankova,
M. Е. Levin,
N. A. Lyubavina,
N. A. Magdeyeva,
K. V. Mazalov,
V. I. Majseenko,
A. S. Makarova,
A. M. Maripov,
A. A. Marusina,
E. S. Melnikov,
N. B. Moiseenko,
F. N. Muradova,
R. G. Muradyan,
A. O. Myshak,
N. M. Nikitina,
B. B. Ogurlieva,
A. A. Odegova,
Yu. M. Omarova,
N. A. Omurzakova,
Sh. O. Ospanova,
E. V. Pahomova,
L. D. Petrov,
S. S. Plastinina,
V. A. Pogrebetskaya,
D. S. Polyakov,
E. V. Ponomarenko,
L. L. Popova,
N. A. Prokofeva,
I. A. Pudova,
N. A. Rakov,
A. N. Rakhimov,
N. A. Rozanova,
S. Serikbolkyzy,
A. A. Simonov,
V. V. Skachkova,
D. V. Soloveva,
I. A. Soloveva,
F. M. Sokhova,
A. K. Subbotin,
I. M. Sukhomlinova,
A. G. Sushilova,
D. R. Tagayeva,
Yu. V. Titojkina,
E. P. Tikhonova,
D. S. Tokmin,
A. A. Tolmacheva,
M. S. Torgunakova,
K. V. Trenogina,
N. A. Trostianetckaia,
D. A. Trofimov,
A. A. Tulichev,
A. T. Tursunova,
N. D. Ulanova,
O. V. Fatenkov,
O. V. Fedorishina,
T. S. Fil,
I. Yu. Fomina,
I. S. Fominova,
I. A. Frolova,
S. M. Tsvinger,
V. V. Tsoma,
M. B. Cholponbaeva,
T. I. Chudinovskikh,
O. A. Shevchenko,
T. V. Sheshina,
E. A. Shishkina,
K. Yu. Shishkov,
S. Yu. Sherbakov,
E. A. Yausheva,
Sh. N. Musaelian,
Yu. N. Belenkov,
G. P. Arutyunov https://doi.org/10.18087/cardio.2021.9.n1680
Abstract
Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.
Material and methods The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients’ privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).
Results The analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).
Conclusion In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.
Supporting agencies: No conflict of interest is reported.
About the Authors
E. I. Tarlovskaya
Eurasian Association of Therapists, Moscow;
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
MD, PhD, Professor, Chairperson of the Eurasian Association of Therapists branch in Nizhny Novgorod, head of the Department of therapy and cardiology
A. G. Arutyunov
Eurasian Association of Therapists, Moscow;
N. I. Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
MD, PhD, Professor, Secretary General of the Eurasian Association of Therapists
A. O. Konradi
V. A. Almazov National Medical Research Center, St. Peterburg
Russian Federation
Russian Federation
Сorresponding member of the Russian Academy of Sciences. MD, PhD, Professor, Deputy General Director of scientific work
Yu. M. Lopatin
Volgograd State Medical University, Volgograd
Russian Federation
Russian Federation
MD, PhD, Professor, Head of the Departrment of Cardiology and Functional Diagnostics, Faculty of Advanced Training for Doctors
A. P. Rebrov
V. I. Razumovsky Saratov State Medical University, Saratov
Russian Federation
Russian Federation
PhD, MD, Professor at the Department of the Internal Medicine
S. N. Tereshchenko
National Medical Research Center of Cardiology, Moscow
Russian Federation
Russian Federation
MD, Professor, head of the Department of myocardial diseases and heart failure
A. I. Chesnikova
Rostov State Medical University, Rostov-on-Don
Russian Federation
Russian Federation
MD, PhD, Professor, Professor in the Department of Internal Medicine No.1
H. G. Hayrapetyan
Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan
Armenia
Armenia
MD, PhD, Doctor of Science, Prof., Head of Cardiology Center, Head of Cardiology Department
A. P. Babin
Nikolae Testemitanu Sate University of Medicine and Pharmacy, Kishinev
Moldova, Republic of
Moldova, Republic of
MD, PhD, Associate Professor at the Department of Family Medicine
I. G. Bakulin
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
MD, PhD, professor, Dean of the General Medicine Faculty, Head of the department of Propedeutics of Internal Diseases, Gastroenterology and Dietology named after S.M. Ryss, Internal Medicine Adviser to the Ministry of Health (the Northwestern federal district of Russia)
N. V. Bakulina
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
MD, PhD, Professor, Head of the department of Internal Diseases, Clinical Pharmacology and Nephrology
L. A. Balykova
N. P. Ogarev National Research Mordovia State University, Saransk
Russian Federation
Russian Federation
MD, PhD, professor, Director of the Medicine Institute, corresponding member of the Russian Academy of Sciences
A. S. Blagonravova
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
Vice rector for research, professor of epidemiology, microbiology and evidence based medicine, M.D.
M. V. Boldina
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
associate Professor of the Department of therapy and cardiology, PhD in Medicine
A. R. Vaisberg
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
Department of Therapy and Cardiology, Associate Professor
A. S. Galyavich
Interregional Clinical Diagnostic Center, Kazan;
Kazan State Medical University, Kazan
Russian Federation
Russian Federation
Chief Cardiologist of the Republic of Tatarstan, Corresponding Member of the Academy of Sciences of the Republic of Tatarstan Head of the Republican Center for Cardiovascular Diseases, Head of the Department of Faculty Therapy
V. V. Gomonova
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
Deputy Chief Physician
N. Yu. Grigorieva
N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod
Russian Federation
Russian Federation
MD, PhD, associate Professor, head of the Department of clinical medicine
I. V. Gubareva
Samara State Medical University, Samara
Russian Federation
Russian Federation
MD, PhD, Dr. Med. Sci, head of Internal Diseases Department, Associated Professor
I. V. Demko
Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk
Russian Federation
Russian Federation
MD, PhD, professor, Head of the Department of Hospital Therapy and Immunology with Postgraduate Education
A. V. Evzerikhina
Krasnogorsk Municipal Hospital №1, Krasnogorsk
Russian Federation
Russian Federation
сandidate of medical sciences, deputy chief physician
A. V. Zharkov
Kirovsk Inter-District Hospital, Kirovsk
Russian Federation
Russian Federation
chief physician
U. K. Kamilova
National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent
Uzbekistan
Uzbekistan
MD, PhD, Professor, Deputy Director of Scientific Work
Z. F. Kim
Kazan Municipal Clinical Hospital №7, Kazan
Russian Federation
Russian Federation
PhD, associate professor, deputy chief physician
T. Yu. Kuznetsova
Petrozavodsk State University, Petrozavodsk
Russian Federation
Russian Federation
MD, PhD, associated professor, head of the department of Faculty Therapy, Phthisiology, Infectious Diseases and Epidemiology
N. V. Lareva
Chita State Medical Academy, Chita
Russian Federation
Russian Federation
MD, PhD, professor, head of the department of Therapy at the Faculty of Advanced Training and Professional Continuing Education
E. V. Makarova
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
MD, DSc, head of the Department of Propaedeutics of internal diseases
S. V. Malchikova
Kirov State Medical University, Kirov
Russian Federation
Russian Federation
MD, PhD, associate professor of the Department of Clinical Therapy
S. V. Nedogoda
Volgograd State Medical University, Volgograd
Russian Federation
Russian Federation
MD, PhD, professor, vice-rector for clinical work and regional health development, head of the Department of Internal Medicine
M. M. Petrova
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
MD, PhD, professor, head of the Department of Polyclinic Therapy and Family Medicine with a Course of Postgraduate Education
I. G. Pochinka
Privolzhsky Research Medical University, Nizhny Novgorod;
Municipal Clinical Hospital #13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod
Russian Federation
Russian Federation
MD, PhD, associate professor at the Department of Enocrinology and Internal Medicine, head of the Department of Cardiology №1
K. V. Protasov
Irkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk
Russian Federation
Russian Federation
MD, PhD, professor, deputy director of research
D. N. Protsenko
Municipal Clinical Hospital №40, Moscow
Russian Federation
Russian Federation
PhD, Dr. med, chief physician, head of the anesthesiology and resuscitation department of the school of continuing medical education
D. Yu. Ruzanau
Gomel State Medical University, Gome
Belarus
Belarus
MD, associate professor, vice-rector for clinical work, professor at the Department of Phthisiology and Pulmonology
S. A. Sayganov
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
MD, PhD, rector, head of the Department of Hospital Therapy and Cardiology
A. S. Sarybaev
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
MD, PhD, Head of the National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov
N. M. Selezneva
N. P. Ogarev National Research Mordovia State University, Saransk
Russian Federation
Russian Federation
MD, associate professor at the Department of Hospital Therapy
A. B. Sugraliev
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kazakhstan
Kazakhstan
PhD, head of the Department of Internal Diseases with a Course of Propaedeutics
I. V. Fomin
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
MD, PhD, associate professor, head of the department of hospital therapy
O. V. Khlynova
Akademician E. A. Vagner Perm State Medical University, Perm
Russian Federation
Russian Federation
MD, PhD, Professor, corresponding member of the Russian Academy of Sciences, Head of the Department of Hospital Therapy
O. Yu. Chizhova
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
MD, PhD, professor at the department of Propedeutics of Internal Diseases, Gastroenterology and Dietology named after S.M. Ryss
I. I. Shaposhnik
South Ural State Medical University, Chelyabinsk
Russian Federation
Russian Federation
MD, PhD, professor, head of the department of the propaedeutics of internal diseases
D. A. Shсukarev
Kirovsk Inter-District Hospital, Kirovsk
Russian Federation
Russian Federation
head of department of infectious deseases
A. K. Abdrahmanova
Kazakh Medical University of Continuous Education, Alma-Ata;
I. Zhekenova Municipal Clinical Hospital for Infectious Diseases, Alma-Ata
Kazakhstan
Kazakhstan
MD, MD, head of the Department of Infectious Diseases, chief physician
S. A. Avetisian
Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan
Armenia
Armenia
clinical resident at cardiology department
H. G. Avoyan
Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan
Armenia
Armenia
cardiologist
K. K. Azarian
Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan
Armenia
Armenia
cardiologist
G. T. Aimakhanova
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kazakhstan
Kazakhstan
cardiologist
D. A. Ayipova
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
head of the department of nephrology
A. Ch. Akunov
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
PhD, head of the Department of urgent cardiology and reanmation-2
M. K. Alieva
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
therapist
A. V. Aparkina
V. I. Razumovsky Saratov State Medical University, Saratov
Russian Federation
Russian Federation
MD, assistant at the Department of Hospital Therapy, Medical Faculty
O. R. Aruslanova
Clinical Cardiological Center, Perm
Russian Federation
Russian Federation
MD, cardiovascular surgeon
E. Yu. Ashina
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
assistant at the Department of Propedeutics of Internal Diseases
O. Yu. Badina
Privolzhsky District Medical Center, Nizhny Novgorod
Russian Federation
Russian Federation
Head of the Infectious Diseases Department
O. Yu. Barisheva
Petrozavodsk State University, Petrozavodsk
Russian Federation
Russian Federation
MD, PhD, associated professor, professor of department of hospital therapy
A. S. Batchayeva
N. I. Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
clinical laboratory diagnostician
A. M. Bitieva
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
cardiologist
I. U. Bikhteyev
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
student
N. A. Borodulina
Clinical Cardiological Center, Perm
Russian Federation
Russian Federation
cardiologist
M. V. Bragin
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
student
A. M. Budu
Municipal Clinical Hospital №1, Kishinev
Moldova, Republic of
Moldova, Republic of
head at the Department of Therapy
L. A. Burygina
P. B. Gannushkin Psychiatric Clinical Hospital №4, Moscow
Russian Federation
Russian Federation
PhD, chief doctor
G. A. Bykova
Akademician E. A. Vagner Perm State Medical University, Perm
Russian Federation
Russian Federation
MD, associate professor at the Department of Hospital Care, pulmonologist
K. R. Vagapova
Polyclinic №1 at the Administrative Department of the President of the Russian Federation, Moscow
Russian Federation
Russian Federation
endocrinologist
D. D. Varlamova
Petrozavodsk State University, Petrozavodsk
Russian Federation
Russian Federation
student
N. N. Vezikova
Petrozavodsk State University, Petrozavodsk
Russian Federation
Russian Federation
MD, PhD, Professor, head of department of hospital therapy
E. A. Verbitskaya
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
resident of Department of Нospital Therapy and Immunology with Postgraduate Education Course
O. E. Vilkova
N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod
Russian Federation
Russian Federation
Dr. Med., senior lecturer at the Department of Clinical Medicine
E. A. Vinnikova
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
attending physician
V. V. Vustina
Perm Regional Clinical Hospital, Perm
Russian Federation
Russian Federation
MD, cardiologist
E. A. Gаlova
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
candidate of medical sciences, deputy director for science of the University clinic
V. V. Genkel
South Ural State Medical University, Chelyabinsk
Russian Federation
Russian Federation
MD, PhD in medicine, associated professor at the Department of Propedeutics of Internal Medicine
E. I. Gorshenina
N. P. Ogarev National Research Mordovia State University, Saransk
Russian Federation
Russian Federation
MD, associate professor at the Department of Hospital Care
R. V. Gostishev
Municipal Clinical Hospital №40, Moscow
Russian Federation
Russian Federation
PhD, Dr. Med., deputy chief physician for Prospective Development
E. V. Grigorieva
V. I. Razumovsky Saratov State Medical University, Saratov
Russian Federation
Russian Federation
MD, associate professor at the Department of Hospital Therapy, Medical Faculty
E. Yu. Gubareva
Samara State Medical University, Samara
Russian Federation
Russian Federation
MD, assistant of the Department of Faculty Therapy, physician at Functional Diagnostics Department
G. M. Dabylova
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kazakhstan
Kazakhstan
assistant of the Department of Internal Diseases with the Course of Propaedeutics
A. I. Demchenko
Samara State Medical University, Samara
Russian Federation
Russian Federation
laboratory assistant at the Department of Faculty Therapy, intern doctor
O. Yu. Dolgikh
Chapaevsk Central Municipal Hospital, Chapaevsk
Russian Federation
Russian Federation
MD, chief physician
M. Y. Duyshobayev
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kyrgyzstan
Kyrgyzstan
physician at the department of urgent cardiology and reanmation-2
D. S. Evdokimov
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
full-time postgraduate student at the Department of Faculty Therapy 2020-2023
K. E. Egorova
V. A Baranov Karelia Republic Hospital, Petrozavodsk
Russian Federation
Russian Federation
gastroenterologist of nephrology department
A. N. Ermilova
Eurasian Association of Therapists, Moscow;
V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Moscow
Russian Federation
Russian Federation
medical advisor, laboratory assistant at thе Department of the Internal Medicine3.Resident in psychiatry 2019-2021
A. E. Zheldybayeva
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kazakhstan
Kazakhstan
assistant of the Department of Internal Diseases with the course of propaedeutics
N. V. Zarechnova
Privolzhsky District Medical Center, Nizhny Novgorod
Russian Federation
Russian Federation
deputy chief physician at Clinical Hospital №2
Yu. D. Zimina
Municipal Clinical Hospital №25, Novosibirsk
Russian Federation
Russian Federation
therapist
S. Yu. Ivanova
Hospital for Veterans of Wars, Petrozavodsk
Russian Federation
Russian Federation
deputy chief physician
E. Yu. Ivanchenko
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
MD, associate professor at the department of therapy and cardiology
M. V. Ilina
Kirovsk Inter-District Hospital, outpatient department, Kirovsk
Russian Federation
Russian Federation
therapist
M. V. Kazakovtseva
Kirov State Medical University, Kirov
Russian Federation
Russian Federation
PhD, associate professor of the Department of Clinical Therapy
E. V. Kazymova
Clinical Hospital at the Samara Station “Russian Railways Medicine”, Samara
Russian Federation
Russian Federation
deputy chief physician
Yu. S. Kalinina
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
assistant at the Department of Нospital Therapy and Immunology with Postgraduate Education Course
N. A. Kamardina
Privolzhsky District Medical Center, Nizhny Novgorod
Russian Federation
Russian Federation
cardiologist
A. M. Karachenova
Chita State Medical Academy, Chita
Russian Federation
Russian Federation
therapist, pulmonologist
I. A. Karetnikov
Irkutsk Regional Clinical Hospital, recipient of the “Badge of Honor” award, Irkutsk
Russian Federation
Russian Federation
deputy chief phisician
N. A. Karoli
V. I. Razumovsky Saratov State Medical University, Saratov
Russian Federation
Russian Federation
MD, PhD, professor at the Department of Hospital Therapy, Medical Faculty
O. V. Karpov
P. B. Gannushkin Psychiatric Clinical Hospital #4, Moscow
Russian Federation
Russian Federation
PhD, psychiatrist
M. Kh. Karsiev
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
attending physician
D. S. Кaskaeva
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
candidate of medical sciences, associate professor of the Department of Outpatient Therapy and Family Medicine with a Course of Postgraduate Education
K. F. Kasymova
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
resident of Department of Нospital Therapy and Immunology with Postgraduate Education Course
Zh. B. Kerimbekova
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
junior researcher at the department of mountain medicine and pulmonary hypertension
A. Sh. Kerimova
Municipal Clinical Hospital №40, Moscow
Russian Federation
Russian Federation
assistant of a chief physician
E. S. Kim
Kazan State Medical University, Kazan;
Kazan Municipal Clinical Hospital №7, Kazan
Russian Federation
Russian Federation
student, administrator
N. V. Kiseleva
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
clinical resident of the Department of Therapy and Cardiology
D. A. Klimenko
Samara State Medical University, Samara
Russian Federation
Russian Federation
laboratory assistant at the Department of Faculty Therapy, intern doctor
A. V. Klimova
N. I. Pirogov Russian National Research Medical University, Moscow;
Municipal Polyclinic №134, Moscow
Russian Federation
Russian Federation
general practitioner, postgraduate student at the Department of the Internal Medicine
O. V. Kovalishena
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
MD, PhD, head of the Department of Epidemiology, Microbiology and Evidence-Based Medicine, director of the Research Institute of Preventive Medicine
E. V. Kolmakova
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
MD, associate professor at the Department of Internal Diseases, Clinical Pharmacology and Nephrology
T. P. Kolchinskaya
Chelyabinsk Municipal Clinical Hospital №1, Chelyabinsk
Russian Federation
Russian Federation
deputy chief physician on outpatient therapy
M. I. Kolyadich
South Ural State Medical University, Chelyabinsk;
Chelyabinsk Municipal Clinical Hospital №1, Chelyabinsk
Russian Federation
Russian Federation
PhD, associate professor of the Department of Propedeutics of Internal Medicine, deputy chief physician
O. V. Kondriakova
Samara State Medical University, Samara
Russian Federation
Russian Federation
student
M. P. Konoval
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
therapist
D. Yu. Konstantinov
Samara State Medical University, Samara
Russian Federation
Russian Federation
PhD, associate professor, head of the Department of Infectious Diseases
E. A. Konstantinova
Samara State Medical University, Samara
Russian Federation
Russian Federation
MD, associate professor at the Department of Infectious Diseases
V. A. Kordukova
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
resident in pulmonology
E. V. Koroleva
Municipal Clinical Hospital №5 of the Nizhny Novgorod Nizhegorodsky District, Nizhny Novgorod
Russian Federation
Russian Federation
physician of the department of cardiology №2
A. Yu. Kraposhina
Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk;
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
PhD in Medicine, associate professor at the Department of Hospital Therapy and Immunology with Postgraduate Education
T. V. Kriukova
Eurasian Association of Therapists, Moscow
Russian Federation
Russian Federation
project manager
A. S. Kuznetsova
South Ural State Medical University, Chelyabinsk
Russian Federation
Russian Federation
PhD, associate professor of the Department of Clinical Therapy
T. Yu. Kuzmina
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
MD, Phd , associate professor at the Depatment of Infecction Diseases and Epidemiology
K. V. Kuzmichev
Municipal Clinical Hospital №13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod
Russian Federation
Russian Federation
resident
Ch. K. Kulchoroeva
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
junior researcher
T. V. Kuprina
Petrozavodsk State University, Petrozavodsk
Russian Federation
Russian Federation
postgraduated student
I. M. Kouranova
Gorodets Central Regional Hospital, Gorodets
Russian Federation
Russian Federation
deputy chief phhysician
L. V. Kurenkova
S. V. Katkov Mordovian Clinical Hospital, Saransk
Russian Federation
Russian Federation
attending physician
N. Yu. Kurchugina
Samara State Medical University, Samara
Russian Federation
Russian Federation
student
N. A. Kushubakova
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
junior researcher
V. I. Levankova
Municipal Polyclinic №1, Petrozavodsk
Russian Federation
Russian Federation
deputy chief physician for therapy
M. Е. Levin
P. B. Gannushkin Psychiatric Clinical Hospital №4, Moscow
Russian Federation
Russian Federation
deputy chief doctor
N. A. Lyubavina
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
PhD, associated professor
N. A. Magdeyeva
V. I. Razumovsky Saratov State Medical University, Saratov
Russian Federation
Russian Federation
MD, associate professor at the Department of Hospital Therapy, Medical Faculty
K. V. Mazalov
Privolzhsky District Medical Center, Nizhny Novgorod
Russian Federation
Russian Federation
head of the Department of Cardiology
V. I. Majseenko
Gomel State Medical University, Gomel
Belarus
Belarus
assistant lecturer at the Department of Phthisiopulmonology with the course of the Faculty of Professional Development and Retraining
A. S. Makarova
Irkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk
Russian Federation
Russian Federation
postgraduate student of the department of cardiology and functional diagnostics
A. M. Maripov
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
head of Department of Pulmonary Hypertension and High altitude medicine, leading researcher
A. A. Marusina
Kirovsk Inter-District Hospital, outpatient department, Kirovsk
Russian Federation
Russian Federation
therapist
E. S. Melnikov
Eurasian Association of Therapists, Moscow;
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
medical advisor, postgraduate student of the department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E. E. Eichwald 2020-2023
N. B. Moiseenko
N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod
Russian Federation
Russian Federation
student
F. N. Muradova
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
postgraduate student of the Department of Therapy and Cardiology
R. G. Muradyan
Global Medical System Clinics and Hospitals, Moscow
Russian Federation
Russian Federation
primary care physician
A. O. Myshak
MedInvestGroup LLC, Moscow
Russian Federation
Russian Federation
data analyst
N. M. Nikitina
V. I. Razumovsky Saratov State Medical University, Saratov
Russian Federation
Russian Federation
MD, PhD, professor at the Department of Hospital Therapy, Medical Faculty
B. B. Ogurlieva
N. I. Pirogov Russian National Research Medical University, Moscow;
Municipal Clinical Hospital №4, Moscow
Russian Federation
Russian Federation
research assistant, сardiologist
A. A. Odegova
Kirov State Medical University, Kirov
Russian Federation
Russian Federation
PhD, assistant of the Department of Clinical Therapy
Yu. M. Omarova
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
postgraduate student of the Department of Therapy and Cardiology
N. A. Omurzakova
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek
Kyrgyzstan
Kyrgyzstan
MD, PhD, deputy director
Sh. O. Ospanova
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kazakhstan
Kazakhstan
assistant at the Department of Internal Diseases with the Course of Propaedeutics
E. V. Pahomova
GBUZ RK "Republican tuberculosis dispensary", Petrozavodsk
Russian Federation
Russian Federation
phthisiatrician of the Department of Pulmonary Tuberculosis for Adults
L. D. Petrov
Health Center Brichen, Brichen
Moldova, Republic of
Moldova, Republic of
director
S. S. Plastinina
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
PhD, assistant professor at the Internal Medicine Department
V. A. Pogrebetskaya
Municipal Clinical Hospital №38 of the Nizhny Novgorod Nizhegorodsky District, Nizhny Novgorod
Russian Federation
Russian Federation
deputy chief physician
D. S. Polyakov
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
PhD, assistant professor at the Department of Therapy and Cardiology
E. V. Ponomarenko
Medical Center “Zimamed”, Krasnodar
Russian Federation
Russian Federation
cardiologist
L. L. Popova
Samara State Medical University, Samara
Russian Federation
Russian Federation
MD, PhD, professor at the Department of Infectious Diseases
N. A. Prokofeva
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
head of the department of therapy №2
I. A. Pudova
Privolzhsky Research Medical University, Nizhny Novgorod;
Municipal Polyclinic №4 of the Nizhny Novgorod Kanavinsky District, Nizhny Novgorod
Russian Federation
Russian Federation
assistant at the Department of Faculty and Polyclinic Therapy, chief physician
N. A. Rakov
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
attending physician
A. N. Rakhimov
21 National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent
Uzbekistan
Uzbekistan
junior researcher
N. A. Rozanova
Krasnogorsk Municipal Hospital №1, Krasnogorsk
Russian Federation
Russian Federation
nurse
S. Serikbolkyzy
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kazakhstan
Kazakhstan
assistant of the Department of Internal Diseases with the Course of Propaedeutics
A. A. Simonov
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
therapist
V. V. Skachkova
Perm Regional Clinical Hospital, Perm
Russian Federation
Russian Federation
attending physician
D. V. Soloveva
Privolzhsky Research Medical University, Nizhny Novgorod
Russian Federation
Russian Federation
student
I. A. Soloveva
Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk;
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
Dr.Med.Sci., professor, associate professor, pulmonologist
F. M. Sokhova
P. B. Gannushkin Psychiatric Clinical Hospital №4, Moscow
Russian Federation
Russian Federation
psychiatrist
A. K. Subbotin
Privolzhsky District Medical Center, Nizhny Novgorod
Russian Federation
Russian Federation
cardiologist
I. M. Sukhomlinova
Hospital for Veterans of Wars, St. Petersburg
Russian Federation
Russian Federation
therapist
A. G. Sushilova
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
attending physician
D. R. Tagayeva
National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent
Uzbekistan
Uzbekistan
junior researcher
Yu. V. Titojkina
N. P. Ogarev National Research Mordovia State University, Saransk
Russian Federation
Russian Federation
resident
E. P. Tikhonova
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
MD, professor, head of the Department of Infectious Diseases and Epidemiology with a Course of Postgraduate Education
D. S. Tokmin
AO “Laboratories of the Future”, Moscow
Russian Federation
Russian Federation
head of analytics
A. A. Tolmacheva
Novosibirsk State Medical University, Novosibirsk;
Clinical Consultative and Diagnostic Polyclinic №27, Novosibirsk
Russian Federation
Russian Federation
postgraduate student, assistant of the department of Faculty Therapy n.a. Zalesskiy G.D., therapist
M. S. Torgunakova
Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
resident of Department of Нospital Therapy and Immunology with Postgraduate Education Course
K. V. Trenogina
Perm Regional Clinical Hospital, Perm
Russian Federation
Russian Federation
MD, cardiologist
N. A. Trostianetckaia
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
PhD, cardiologist
D. A. Trofimov
Kazan State Medical University, Kazan;
Kazan Municipal Clinical Hospital №7, Kazan
Russian Federation
Russian Federation
student, nurse (Department of Cardiology №4)
A. A. Tulichev
Privolzhsky Research Medical University, Nizhny Novgorod;
Municipal Clinical Hospital №3, Nizhny Novgorod
Russian Federation
Russian Federation
PhD, assistant of Department of Internal Medicine Propedeutics, head of the Emergency Room
A. T. Tursunova
S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata
Kazakhstan
Kazakhstan
assistant of the Department of Internal Diseases with the Course of Propaedeutics
N. D. Ulanova
Municipal Clinical Hospital #13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod
Russian Federation
Russian Federation
resident
O. V. Fatenkov
Samara State Medical University, Samara
Russian Federation
Russian Federation
MD, PhD, assistant professor, director of Clinic, head of the Department of Faculty Therapy, chief therapist of the Ministry of Healthcare of Samara Region
O. V. Fedorishina
Irkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk
Russian Federation
Russian Federation
MD, associate professor at the department of cardiology and functional diagnostics
T. S. Fil
I. I. Mechnikov North-Western State Medical University, St. Petersburg
Russian Federation
Russian Federation
head of the department of gastroenterology
I. Yu. Fomina
Privolzhsky Research Medical University, Nizhny Novgorod;
Municipal Polyclinic #1, Nizhny Novgorod
Russian Federation
Russian Federation
PhD, associate professor at the Department of Faculty and Outpatient Therapy, chief physician
I. S. Fominova
N. P. Ogarev National Research Mordovia State University, Saransk
Russian Federation
Russian Federation
resident
I. A. Frolova
Privolzhsky District Medical Center, Nizhny Novgorod
Russian Federation
Russian Federation
cardiologist
S. M. Tsvinger
Chita State Medical Academy, Chita
Russian Federation
Russian Federation
MD, rheumatologist, associate professor at the department of ambulatory care with courses of medical rehabilitation
V. V. Tsoma
Volgograd State Medical University, Volgograd
Russian Federation
Russian Federation
PhD, associate professor, Department of Internal Medicine, Institute of Continuing Medical Education, head of Additional Professional Education Department, chief freelance pulmonologist of the Health Committee of the Volgograd Region
M. B. Cholponbaeva
M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek,
Kyrgyzstan
Kyrgyzstan
junior researcher
T. I. Chudinovskikh
Kirov State Medical University, Kirov
Russian Federation
Russian Federation
PhD, assistant of the Department of Hospital Therapy
O. A. Shevchenko
Samara Municipal Polyclinic №3, Samara
Russian Federation
Russian Federation
general practitioner
T. V. Sheshina
N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod
Russian Federation
Russian Federation
assistant at the department of clinical medicine
E. A. Shishkina
Akademician E. A. Vagner Perm State Medical University, Perm
Russian Federation
Russian Federation
MD, associate professor at the Hopspital Therapy and Cardiology Department
K. Yu. Shishkov
Samara State Medical University, Samara
Russian Federation
Russian Federation
student
S. Yu. Sherbakov
Kazan State Medical Academy, Branch of the Russian Medical Academy of Continuing Professional Education, Kazan
Russian Federation
Russian Federation
resident in anaesthesiology and resuscitation
E. A. Yausheva
N. P. Ogarev National Research Mordovia State University, Saransk
Russian Federation
Russian Federation
resident
Sh. N. Musaelian
Erevan State Medical University, Erevan
Armenia
Armenia
clinical resident at cardiology department
Yu. N. Belenkov
The First Moscow state medical University I. M. Sechenov
Russian Federation
Russian Federation
Аcademician of RAS, MD, PhD, head of Department of hospital therapy №1 medical faculty
G. P. Arutyunov
Eurasian Association of Therapists, Moscow;
N. I. Pirogov Russian National Research Medical University, Moscow
Professor, Head of the Department of Internal Medicine
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