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Position Paper. The role of iron deficiency in patients with chronic heart failure and current corrective approaches

https://doi.org/10.18087/cardio.2020.1.n961

About the Authors

V. Yu. Mareev
Lomonosov Moscow State University
Russian Federation
Moscow


S. R. Gilyarevskiy
Russian Medical Academy of Postgraduate Education
Russian Federation
Moscow


Yu. V. Mareev
National Medical Research Center for Preventive Medicine
Russian Federation
Moscow


Yu. L. Begrambekova
Lomonosov Moscow State University
Russian Federation
Moscow


Yu. N. Belenkov
Sechenov Moscow State Medical University
Russian Federation
Moscow


Yu. A. Vasyuk
Moscow State Medical and Dental University named after Evdokimov
Russian Federation
Moscow


A. S. Galyavich
Kazan State Medical University
Russian Federation
Kazan


G. E. Gendlin
Russian National Research Medical University named after Pirogov
Russian Federation
Moscow


M. G. Glezer
Sechenov Moscow State Medical University
Russian Federation
Moscow


Zh. D. Kobalava
Russian State University of Peoples’ Friendship
Russian Federation
Moscow


T. A. Lelyavina
Almazov National Medical Research Center
Russian Federation
St. Petersburg


Ya. A. Orlova
Lomonosov Moscow State University
Russian Federation
Moscow


I. V. Fomin
Nizhny Novgorod State Medical Academy
Russian Federation
Nizhny Novgorod


I. I. Shaposhnik
Ural State Medical University
Russian Federation
Chelyabinsk


References

1. Beverborg N.G., van Veldhuisen D.J., van der Meer P. Anemia in Heart Failure. Still Relevant? J Am Coll Cardiol HF 2018;6:201–208. DOI: 10.1016/j.jchf.2017.08.023.

2. van Veldhuisen D.J., Anker S.D., Ponikowski P., Macdougall I.C. Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat Rev Cardiol 2011;8:485–493. DOI: 10.1038/nrcardio.2011.77.

3. Ponikowski P., Voors A.A., Anker S.D., Bueno H., Cleland J.G.F., Coats A.J.S., Falk V., González-Juanatey J.R., Harjola V.P., Jankowska E.A., Jessup M., Linde C., Nihoyannopoulos P., Parissis J.T., Pieske B., Riley J.P., Rosano G.M.C., Ruilope L.M., Ruschitzka F., Rutten F.H., van der Meer P.; ESC Scientific Document Group. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 2016; 37:2129–2200. DOI: 10.1093/eurheartj/ehw128.

4. Beard J.L. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 2001;131:568S–580S. DOI: 10.1093/jn/131.2.568S

5. Anker S.D., Colet J.C., Filippatos G., Willenheimer R., Dickstein K., Drexler H., Lüscher T.F., Mori C., von Eisenhart Rothe B., Pocock S., Poole-Wilson P.A, Ponikowski P.; FAIR-HF committees and investigators. Rationale and design of Ferinject assessment in patients with IRon deficiency and chronic Heart Failure (FAIRHF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia. Eur J Heart Fail 2009;11:1084–1091. DOI: 10.1093/eurjhf/hfp140.

6. Okonko D.O., Mandal A.K., Missouris C.G., Poole-Wilson P.A. Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. J Am Coll Cardiol 2011;58:1241–1251. DOI: 10.1016/j.jacc.2011.04.040.

7. Jankowska E.A., Rozentryt P., Witkowska A., Nowak J., Hartmann O., Ponikowska B., Borodulin-Nadzieja L., von Haehling S., Doehner W., Banasiak W., Polonski L., Filippatos G., Anker S.D., Ponikowski P. Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure. J Card Fail 2011;17:899–906. DOI: 10.1016/j.cardfail.2011.08.003.

8. Haas J.D., Brownlie T. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 2001;131:676S–690S. DOI: 10.1093/jn/131.2.676S.

9. Enjuanes C., Bruguera J., Grau M., Cladellas M., Gonzalez G., Meroño O., Moliner-Borja P., Verdú J.M., Farré N., Comín-Colet J. Iron status in chronic heart failure: impact on symptoms, functional class and submaximal exercise capacity. Rev Esp Cardiol (Engl Ed) 2016;69:247–255. DOI: 10.1016/j.rec.2015.08.018.

10. Comin-Colet J., Enjuanes C., Gonzalez G., Torrens A., Cladellas M., Meroño O., Ribas N., Ruiz S., Gómez M., Verdú J.M., Bruguera J. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. Eur J Heart Fail 2013;15:1164–1172. DOI: 10.1093/eurjhf/hft083.

11. Enjuanes C., Klip I.T., Bruguera J., Cladellas M., Ponikowski P., Banasiak W., van Veldhuisen D.J., van der Meer P., Jankowska E.A., ComínColet J. Iron deficiency and health-related quality of life in chronic heart failure: results from a multicenter European study. Int J Cardiol 2014;174:268–275. DOI: 10.1016/j.ijcard.2014.03.169.

12. Nunez J., Comin-Colet J., Minana G., Núñez E., Santas E., Mollar A., Valero E., García-Blas S., Cardells I., Bodí V., Chorro F.J., Sanchis J. Iron deficiency and risk of early readmission following a hospitalization for acute heart failure. Eur J Heart Fail 2016;18:798–802. DOI: 10.1002/ejhf.513.

13. Klip I.T., Comin-Colet J., Voors A.A., Ponikowski P., Enjuanes C., Banasiak W., Lok D.J., Rosentryt P., Torrens A., Polonski L., van Veldhuisen D.J., van der Meer P., Jankowska E.A. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 2013;165:575–582.e3. DOI: 10.1016/j.ahj.2013.01.017.

14. Jankowska E.A., Rozentryt P., Witkowska A., Nowak J., Hartmann O., Ponikowska B., Borodulin-Nadzieja L., Banasiak W., Polonski L., Filippatos G., McMurray J.J., Anker S.D., Ponikowski P. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J 2010;31:1872–1880. DOI: 10.1093/eurheartj/ehq158.

15. Nanas J.N., Matsouka C., Karageorgopoulos D., Leonti A., Tsolakis E., Drakos S.G., Tsagalou E.P., Maroulidis G.D., Alexopoulos G.P., Kanakakis J.E., Anastasiou-Nana M.I. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006;48:2485–2489. DOI: 10.1016/j.jacc.2006.08.034.

16. Parikh A., Natarajan S., Lipsitz S.R., Katz S.D. Iron deficiency in community-dwelling US adults with self-reported heart failure in the National Health and Nutrition Examination Survey III:

17. prevalence and associations with anemia and inflammation. Circ Heart Fail 2011;4:599–606. DOI: 10.1161/CIRCHEARTFAILURE.111.960906.

18. Yeo T.J., Yeo P.S., Ching-Chiew Wong R., Ong H.Y., Leong K.T., Jaufeerally F., Sim D., Santhanakrishnan R., Lim S.L., Chan M.M.Y., Chai P., Low A.F., Ling L.H., Ng T.P., Richards A.M., Lam C.S. Iron deficiency in a multi-ethnic Asian population with and without heart failure: prevalence, clinical correlates, functional significance and prognosis. Eur J Heart Fail 2014;16:1125–1132. DOI: 10.1002/ejhf.161.

19. von Haehling S., Gremmler U., Krumm M., Mibach F., Schön N., Taggeselle J., Dahm J.B., Angermann C.E. Prevalence and clinical impact of iron deficiency and anaemia among outpatients with chronic heart failure: The PrEP Registry. Clin Res Cardiol 2017;106:436–443. DOI: 10.1007/s00392-016-1073-y.

20. Grote Beverborg N., Klip I.T., Meijers W.C., Voors A.A., Vegter E.L., van der Wal H.H., Swinkels D.W., van Pelt J., Mulder A.B., Bulstra S.K., Vellenga E., Mariani M.A., de Boer R.A., van Veldhuisen D.J., van der Meer P. Definition of Iron Deficiency Based on the Gold Standard of Bone Marrow Iron Staining in Heart Failure Patients. Circ Heart Fail 2018;11(2):e004519. DOI: 10.1161/CIRCHEARTFAILURE.117.004519.

21. Anker S.D., Kirwan B.A., van Veldhuisen D.J., Filippatos G., CominColet J., Ruschitzka F., Lüscher T.F., Arutyunov G.P., Motro M., Mori C., Roubert B., Pocock S.J., Ponikowski P. Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis. Eur J Heart Fail 2018;20:125–133. DOI: 10.1002/ejhf.823.

22. Cacoub P., Vandewalle C., Peoc’h K. Using transferrin saturation as a diagnostic criterion for iron deficiency: A systematic review. Crit Rev Clin Lab Sci. 2019;56:526–532. DOI: 10.1080/10408363.2019.1653820.

23. Lewis G.D., Semigran M.J., Givertz M.M., Malhotra R., Anstrom K.J., Hernandez A.F., Shah M.R., Braunwald E. Oral iron therapy for heart failure with reduced ejection fraction: design and rationale for oral iron repletion effects on oxygen uptake in heart failure. Circ Heart Fail 2016;9:e000345. DOI: 10.1161/CIRCHEARTFAILURE.115.000345.

24. Toblli J.E., Lombraña A., Duarte P., Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 2007;50:1657–1665. DOI: 10.1016/j.jacc.2007.07.029.

25. Okonko D.O., Grzeslo A., Witkowski T., Mandal A.K., Slater R.M., Roughton M., Foldes G., Thum T., Majda J., Banasiak W., Missouris C.G., Poole-Wilson P.A., Anker S.D., Ponikowski P. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol 2008;51:103–112. DOI: 10.1016/j.jacc.2007.09.036.

26. Anker S.D., Comin Colet J., Filippatos G., Willenheimer R., Dickstein K., Drexler H., Lüscher T.F., Bart B., Banasiak W., Niegowska J., Kirwan B.A., Mori C., von Eisenhart Rothe B., Pocock S.J., PooleWilson P.A., Ponikowski P.; FAIR-HF Trial Investigators. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 2009;361:2436–2448. 10.1056/NEJMoa0908355.

27. Ponikowski P., Van Veldhuisen D.J., Comin-Colet J., Ertl G., Komajda M., Mareev V., McDonagh T., Parkhomenko A., Tavazzi L., Levesque V., Mori C., Roubert B., Filippatos G., Ruschitzka F., Anker SD.; CONFIRM-HF Investigators. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J 2015;36:657–668. DOI: 10.1093/eurheartj/ehu385.

28. Van Veldhuisen D.J., Ponikowski P., van der Meer P., Metra M., Böhm M., Doletsky A., Voors A.A., Macdougall I.C., Anker S.D., Roubert B., Zakin L., Cohen-Solal A.; EFFECT-HF Investigators. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation 2017;136:1374–1383. DOI: 10.1161/CIRCULATIONAHA.117.027497.

29. McDonagh T., Damy T., Doehner W., Lam C.S.P., Sindone A., van der Meer P., Cohen-Solal A., Kindermann I., Manito N., Pfister O., Pohjantähti-Maaroos H., Taylor J., Comin-Colet J. Screening, diagnosis and treatment of iron deficiency in chronic heart failure: putting the 2016 European Society of Cardiology heart failure guidelines into clinical practice. Eur J Heart Fail 2018;20:1664–1672. DOI: 10.1002/ejhf.1305.

30. Adlbrecht C., Kommata S., Hülsmann M., Szekeres T., Bieglmayer C., Strunk G., Karanikas G., Berger R., Mörtl D., Kletter K., Maurer G., Lang I.M., Pacher R. Chronic heart failure leads to an expanded

31. plasma volume and pseudoanaemia, but does not lead to a reduction in the body’s red cell volume. Eur Heart J 2008;29:2343–2350. DOI: 10.1093/eurheartj/ehn359.

32. Grote Beverborg N., Verweij N., Klip I.T., van der Wal H.H., Voors A.A., van Veldhuisen D.J., Gansevoort R.T., Bakker S.J., van der Harst P., van der Meer P. Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates. PLoS One 2015;10:e0125215.

33. Groenveld H.F., Januzzi J.L., Damman K., van Wijngaarden J., Hillege H.L., van Veldhuisen D.J., van der Meer P. Anemia and mortality in heart failure patients. a systematic review and meta-analysis. J Am Coll Cardiol 2008;52:818–827. DOI: 10.1016/j.jacc.2008.04.061.

34. Tang W.H., Tong W., Jain A., Francis G.S., Harris C.M., Young J.B. Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure. J Am Coll Cardiol 2008;51:569–576. DOI: 10.1016/j.jacc.2007.07.094.

35. Waldum B., Westheim A.S., Sandvik L., Flønæs B., Grundtvig M., Gullestad L., Hole T., Os I. Baseline anemia is not a predictor of allcause mortality in outpatients with advanced heart failure or severe renal dysfunction. Results from the Norwegian Heart Failure Registry. J Am Coll Cardiol 2012;59:371–378. DOI: 10.1016/j.jacc.2011.10.864.

36. Nanas J.N., Matsouka C., Karageorgopoulos D., Leonti A., Tsolakis E., Drakos S.G., Tsagalou E.P., Maroulidis G.D., Alexopoulos G.P., Kanakakis J.E., Anastasiou-Nana M.I. Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 2006;48:2485–2489. DOI: 10.1016/j.jacc.2006.08.034.

37. van der Meer P., Lok D.J., Januzzi J.L., de la Porte P.W., Lipsic E., van Wijngaarden J., Voors A.A., van Gilst W.H., van Veldhuisen D.J. Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients. Eur Heart J 2008;29:1510–1515. DOI: 10.1093/eurheartj/ehn205.

38. Westenbrink B.D., Visser F.W., Voors A.A., Smilde T.D., Lipsic E., Navis G., Hillege H.L., van Gilst W.H., van Veldhuisen D.J. Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well. Eur Heart J 2007;28:166–171. DOI: 10.1093/eurheartj/ehl419.

39. Westenbrink B.D., Voors A.A., De Boer R.A., Schuringa J.J., Klinkenberg T., van der Harst P., Vellenga E., van Veldhuisen D.J., van Gilst W.H. Bone marrow dysfunction in chronic heart failure patients. Eur J Heart Fail 2010;12:676–684. DOI: 10.1093/eurjhf/hfq061.

40. van der Meer P., Voors A.A., Lipsic E., Smilde T.D., van Gilst W.H., van Veldhuisen D.J. Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure. J Am Coll Cardiol 2004;44:63–67. doi: 10.1016/j.jacc.2004.03.052.

41. van der Meer P., Lipsic E., Westenbrink B.D., van de Wal R.M., Schoemaker R.G., Vellenga E., van Veldhuisen D.J., Voors A.A., van Gilst W.H. Levels of hematopoiesis inhibitor N-acetyl-seryl-aspartyl-lysyl-proline partially explain the occurence of anemia in heart failure. Circulation 2005;112:1743–1747. DOI: 10.1161/CIRCULATIONAHA.105.549121.

42. Ishani A., Weinhandl E., Zhao Z., Gilbertson D.T., Collins A.J., Yusuf S., Herzog C.A. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 2005;45:391–399. DOI: 10.1016/j.jacc.2004.10.038.

43. Komajda M., Anker S.D., Charlesworth A., Okonko D., Metra M., Di Lenarda A., Remme W., Moullet C., Swedberg K., Cleland J.G., Poole-Wilson P.A. The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J 2006;27:1440–1446. DOI: 10.1093/eurheartj/ehl012.

44. Weiskopf R.B., Viele M.K., Feiner J., Kelley S., Lieberman J., Noorani M., Leung J.M., Fisher D.M., Murray W.R., Toy P., Moore M.A. Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA 1998;279:217—221. DOI: 10.1001/jama.279.3.217.

45. Weiskopf R.B., Viele M.K., Feiner J., Kelley S., Lieberman J., Noorani M., Leung J.M., Fisher D.M. Ebner N., Jankowska E.A., Ponikowski P., Lainscak M., Elsner S., Sliziuk V., Steinbeck L., Kube J., Bekfani T., Scherbakov N., Valentova M., Sandek A., Doehner W., Springer J., Anker S.D., von Haehling S. The impact of iron deficiency and anaemia on exercise capacity and outcomes in patients with chronic heart failure. Results from the studies investigating co-morbidities aggravating heart failure. Int J Cardiol 2016;205:6–12. DOI: 10.1016/j.ijcard.2015.11.178.

46. Klip I.T., Jankowska E.A., Enjuanes C., Voors A.A., Banasiak W., Bruguera J., Rozentryt P., Polonski L., van Veldhuisen D.J., Ponikowski P., Comin-Colet J., van der Meer P. The additive burden of iron deficiency in the cardiorenal-anaemia axis: scope of a problem and its consequences. Eur J Heart Fail 2014;16:655–662. DOI: 10.1002/ejhf.84.

47. Garty M., Cohen E., Zuchenko A., Behar S., Boyko V., Iakobishvili Z., Mittelman M., Battler A., Shotan A., Gottlieb S., Caspi A., Hasdai D. Blood transfusion for acute decompensated heart failure-friend or foe? Am Heart J 2009;158:653–658. DOI: 10.1016/j.ahj.2009.08.001.

48. Kao D.P., Kreso E., Fonarow G.C., Krantz M.J. Characteristics and outcomes among heart failure patients with anemia and renal insufficiency with and without blood transfusions (public discharge data from California 2000-2006). Am J Cardiol 2011;107:69–73. DOI: 10.1016/j.amjcard.2010.08.046.

49. Qaseem A., Humphrey L.L., Fitterman N., Starkey M., Shekelle P.; Clinical Guidelines Committee of the American College of Physicians. Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2013;159:770–779. DOI: 10.7326/0003-4819-159-11-201312030-00009.

50. Swedberg K., Young J.B., Anand I.S., Cheng S., Desai A.S., Diaz R., Maggioni A.P., McMurray J.J., O’Connor C., Pfeffer M.A., Solomon S.D., Sun Y., Tendera M., van Veldhuisen D.J.; RED-HF Committees; RED-HF Investigators. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 2013;368:1210–1219. DOI: 10.1056/NEJMoa1214865.

51. Bello N.A., Lewis E.F., Desai A.S., Anand I.S., Krum H., McMurray J.J., Olson K., Solomon S.D., Swedberg K., van Veldhuisen D.J., Young J.B., Pfeffer M.A. Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease. Eur J Heart Fail 2015;17:1201–1207. DOI: 10.1002/ejhf.412.


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For citations:


Mareev V.Yu., Gilyarevskiy S.R., Mareev Yu.V., Begrambekova Yu.L., Belenkov Yu.N., Vasyuk Yu.A., Galyavich A.S., Gendlin G.E., Glezer M.G., Kobalava Zh.D., Lelyavina T.A., Orlova Ya.A., Fomin I.V., Shaposhnik I.I. Position Paper. The role of iron deficiency in patients with chronic heart failure and current corrective approaches. Kardiologiia. 2020;60(1):99-106. https://doi.org/10.18087/cardio.2020.1.n961

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