Неинвазивные показатели работы миокарда в оценке систолической функции левого желудочка

Обзор литературы посвящен новому способу неинвазивной комплексной оценки систолической функции левого желудочка (ЛЖ) с помощью эхокардиографической технологии расчета показателей работы миокарда методом построения кривых давление–деформация. В связи с тем что новый метод учитывает влияние постнагрузки на сократительную функцию миокарда, представлены данные, показывающие превосходство оценки работы миокарда ЛЖ над speckle-tracking эхокардиографией и другими методиками в диагностике некоторых заболеваний. В обзоре приводятся описание метода, преимущества и ограничения его использования. Анализируются результаты основных исследований, посвященных оценке показателей работы миокарда ЛЖ. Обсуждаются перспективы внедрения и практического применения нового метода в диагностике сердечно-сосудистых заболеваний и стратификации риска для различных групп пациентов.

Работа миокарда, кривая давление–деформация, speckle-tracking, левый желудочек

1. Alekhin M.N. Ultrasound methods for assessment of myocardial deformation and their clinical significance. -М.: Vidar-M;2012. - 88 p. [Russian: Алехин М.Н. Ультразвуковые методы оценки деформации миокарда и их клиническое значение. - М.: Видар-М, 2012. -88с]. ISBN 978-5-88429-164-5

2. Mondillo S, Galderisi M, Mele D, Cameli M, Lomoriello VS, Zacà V et al. Speckle-tracking echocardiography: a new technique for assessing myocardial function. Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine. 2011;30(1):71-83. https://doi.org/10.7863/jum.2011.30.1.71

3. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal - Cardiovascular Imaging. 2015;16(3):233-71. https://doi.org/10.1093/ehjci/jev014

4. Stanton T, Leano R, Marwick TH. Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring. Circulation. Cardiovascular Imaging. 2009;2(5):356-64. https://doi.org/10.1161/CIRCIMAGING.109.862334

5. Mignot A, Donal E, Zaroui A, Reant P, Salem A, Hamon C et al. Global Longitudinal Strain as a Major Predictor of Cardiac Events in Patients with Depressed Left Ventricular Function: A Multicenter Study. Journal of the American Society of Echocardiography. 2010;23(10):1019-24. https://doi.org/10.1016/j.echo.2010.07.019

6. Chan J, Edwards NFA, Khandheria BK, Shiino K, Sabapathy S, Anderson B et al. A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy. European Heart Journal - Cardiovascular Imaging. 2019;20(1):31-9. https://doi.org/10.1093/ehjci/jey131

7. Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme EW et al. A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work. European Heart Journal. 2012;33(6):724-33. https://doi.org/10.1093/eurheartj/ehs016

8. Suga H. Total mechanical energy of a ventricle model and cardiac oxygen consumption. American Journal of Physiology-Heart and Circulatory Physiology. 1979;236(3):H498-505. https://doi.org/10.1152/ajpheart.1979.236.3.H498

9. Takaoka H, Takeuchi M, Odake M, Yokoyama M. Assessment of myocardial oxygen consumption (Vo2) and systolic pressure-volume area (PVA) in human hearts. European Heart Journal. 1992;13(suppl E):85-90. https://doi.org/10.1093/eurheartj/13.suppl_E.85

10. Foëx P, Leone BJ. Pressure-volume loops: A dynamic approach to the assessment of ventricular function. Journal of Cardiothoracic and Vascular Anesthesia. 1994;8(1):84-96. https://doi.org/10.1016/1053-0770(94)90020-5

11. Human physiology. Schmidt RF, Thews G, editors -M.: MIR;2005. -314 p. [Russian: Циммерман М., Ениг В., Вутке В., Вайс Х., Елькман В., Антони Х. и др. Физиология человека. В 3-х томах. Т. 2. Пер. с англ./Под ред. Р. Шмидта и Г. Тевса. - М.: Мир, 2005. - 314с]. ISBN 5-03-003576-1

12. Tyberg JV, Forrester JS, Wyatt HL, Goldner SJ, Parmley WW, Swan HJC. An Analysis of Segmental Ischemic Dysfunction Utilizing the Pressure-Length Loop. Circulation. 1974;49(4):748-54. https://doi.org/10.1161/01.CIR.49.4.748

13. Forrester JS, Tyberg JV, Wyatt HL, Goldner S, Parmely WW, Swan HJ. Pressure-length loop: a new method for simultaneous measurement of segmental and total cardiac function. Journal of Applied Physiology. 1974;37(5):771-5. https://doi.org/10.1152/jappl.1974.37.5.771

14. Delhaas T, Arts T, Prinzen FW, Reneman RS. Regional fibre stress-fibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart. The Journal of Physiology. 1994;477(3):481-96. https://doi.org/10.1113/jphysiol.1994.sp020209

15. Urheim S, Rabben SI, Skulstad H, Lyseggen E, Ihlen H, Smiseth OA. Regional myocardial work by strain Doppler echocardiography and LV pressure: a new method for quantifying myocardial function. American Journal of Physiology-Heart and Circulatory Physiology. 2005;288(5):H2375-80. https://doi.org/10.1152/ajpheart.00946.2004

16. Konstantinov B.A., Sandrikov V.A., Yakovlev V.F. Evaluation of productivity and analysis of the cyclic work of the heart in clinical practice. -L.: Nauka;1986. - 140 p. [Russian: Константинов Б.А., Сандриков В.А., Яковлев В.Ф. Оценка производительности и анализ поцикловой работы сердца в клинической практике. - Л.: Наука, 1986. - 140с]

17. Konstantinov B.A., Sandrikov V.A., Kulagina T.Yu. Myocardial deformation and pumping function of the heart. -M.: LLC ‘Firm STROM’;2006. - 304 p. [Russian: Константинов Б.А., Сандриков В.А., Кулагина Т.Ю. Деформация миокарда и насосная функция сердца. 1-е издание. -М.: ООО «Фирма СТРОМ», 2006. -304с]. ISBN 978-5-900094-22-7

18. Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Gjesdal O et al. Assessment of wasted myocardial work: a novel method to quantify energy loss due to uncoordinated left ventricular contractions. American Journal of Physiology-Heart and Circulatory Physiology. 2013;305(7):H996-1003. https://doi.org/10.1152/ajpheart.00191.2013

19. van der Bijl P, Kostyukevich M, El Mahdiui M, Hansen G, Samset E, Ajmone Marsan N et al. A Roadmap to Assess Myocardial Work. JACC: Cardiovascular Imaging. 2019;12(12):2549-54. https://doi.org/10.1016/j.jcmg.2019.05.028

20. Lancellotti P, Badano LP, Lang RM, Akhaladze N, Athanassopoulos GD, Barone D et al. Normal Reference Ranges for Echocardiography: rationale, study design, and methodology (NORRE Study). European Heart Journal - Cardiovascular Imaging. 2013;14(4):303-8. https://doi.org/10.1093/ehjci/jet008

21. Manganaro R, Marchetta S, Dulgheru R, Ilardi F, Sugimoto T, Robinet S et al. Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study. European Heart Journal - Cardiovascular Imaging. 2019;20(5):582-90. https://doi.org/10.1093/ehjci/jey188

22. Manganaro R, Marchetta S, Dulgheru R, Sugimoto T, Tsugu T, Ilardi F et al. Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function: results from the EACVI NORRE study. European Heart Journal - Cardiovascular Imaging. 2019;jez203. [Epub ahead of print]. https://doi.org/10.1093/ehjci/jez203

23. Vecera J, Penicka M, Eriksen M, Russell K, Bartunek J, Vanderheyden M et al. Wasted septal work in left ventricular dyssynchrony: a novel principle to predict response to cardiac resynchronization therapy. European Heart Journal - Cardiovascular Imaging. 2016;17(6):624-32. https://doi.org/10.1093/ehjci/jew019

24. Galli E, Leclercq C, Fournet M, Hubert A, Bernard A, Smiseth OA et al. Value of Myocardial Work Estimation in the Prediction of Response to Cardiac Resynchronization Therapy. Journal of the American Society of Echocardiography. 2018;31(2):220-30. https://doi.org/10.1016/j.echo.2017.10.009

25. Galli E, Leclercq C, Hubert A, Bernard A, Smiseth OA, Mabo P et al. Role of myocardial constructive work in the identification of responders to CRT. European Heart Journal - Cardiovascular Imaging. 2018;19(9):1010-8. https://doi.org/10.1093/ehjci/jex191

26. Galli E, Hubert A, Le Rolle V, Hernandez A, Smiseth OA, Mabo P et al. Myocardial constructive work and cardiac mortality in resynchronization therapy candidates. American Heart Journal. 2019;212:53-63. https://doi.org/10.1016/j.ahj.2019.02.008

27. van der Bijl P, Vo NM, Kostyukevich MV, Mertens B, Ajmone Marsan N, Delgado V et al. Prognostic implications of global, left ventricular myocardial work efficiency before cardiac resynchronization therapy. European Heart Journal - Cardiovascular Imaging. 2019;20(12):1388-94. https://doi.org/10.1093/ehjci/jez095

28. Galli E, Vitel E, Schnell F, Le Rolle V, Hubert A, Lederlin M et al. Myocardial constructive work is impaired in hypertrophic cardiomyopathy and predicts left ventricular fibrosis. Echocardiography. 2019;36(1):74-82. https://doi.org/10.1111/echo.14210

29. El Mahdiui M, van der Bijl P, Abou R, Ajmone Marsan N, Delgado V, Bax JJ. Global Left Ventricular Myocardial Work Efficiency in Healthy Individuals and Patients with Cardiovascular Disease. Journal of the American Society of Echocardiography. 2019;32(9):1120-7. https://doi.org/10.1016/j.echo.2019.05.002

30. Boe E, Russell K, Eek C, Eriksen M, Remme EW, Smiseth OA et al. Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome. European Heart Journal - Cardiovascular Imaging. 2015;16(11):1247-55. https://doi.org/10.1093/ehjci/jev078

31. Edwards NFA, Scalia GM, Shiino K, Sabapathy S, Anderson B, Chamberlain R et al. Global Myocardial Work Is Superior to Global Longitudinal Strain to Predict Significant Coronary Artery Disease in Patients With Normal Left Ventricular Function and Wall Motion. Journal of the American Society of Echocardiography. 2019;32(8):947-57. https://doi.org/10.1016/j.echo.2019.02.014

32. Konstantinov B.A., Sandrikov V.A., Yakovlev V.F., Simonov V.A. Dynamics of the pumping function of the heart. -M.: Nauka;1989. -148 p. [Russian: Константинов Б.А., Сандриков В.А., Яковлев В.Ф., Симонов В.А. Динамика насосной функции сердца. -М.: Наука, 1989. -148c]. ISBN 978-5-02-004636-8