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Antibiotic prophylaxis for infective endocarditis: current approaches

https://doi.org/10.18087/cardio.2020.12.n886

Abstract

This review addresses current views on prevention of infectious endocarditis (IE). History of establishing the concept of antibacterial prophylaxis (ABP), major approaches, and substantiation of changes in ABP in recent years are described. Recent international and national guidelines are highlighted, specifically, guidelines of the European Society of Cardiologists, American Heart Association/American College of Cardiology, and the Japanese Circulation Society. The review presents critical evaluation of previously approved international guidelines, including analysis of the effect of partial or complete ABP restriction on IE morbidity and incidence of complications. Special attention is paid to awareness of practitioners, particularly dentists, about ABP issues in their practice. Aspects of validity and key features of preventive approaches in implanting cardiac electronic devices and transcatheter aortic valve implantation are discussed.

About the Authors

G. G. Taradin
State Educational Organization of Higher Professional Education “M. Gorky Donetsk National Medical University”, Donetsk, Ukraine
Ukraine
Head of Therapy Department, Division of Internship and Postgraduate Training, Associate Professor


N. T. Vatutin
State Educational Organization of Higher Professional Education “M. Gorky Donetsk National Medical University”, Donetsk, Ukraine
Ukraine
Head of Hospital Therapy Department, Professor


G. A. Ignatenko
State Educational Organization of Higher Professional Education “M. Gorky Donetsk National Medical University”, Donetsk, Ukraine
Ukraine
Head of Department of Propedeutic and Internal Medicine, Professor


E. Ju. Ponomareva
Federal State Budgetary Educational Institution of Higher Education “Saratov State Medical University named after V.I. Razumovsky”, Saratov, Russia
Russian Federation
Associate Professor of the Department of Hospital Therapy


Bernard David Prendergast
Department of Cardiology, St. Thomas Hospital, London, United Kingdom
United Kingdom
Professor of Interventional Cardiology and Valvular Heart Disease


References

1.

2. Demin A.A. The infective endocarditis (prevention, diagnosis criteria and treatment): key points 2010. Rational Pharmacotherapy in Cardiology. 2010;6(5):747–8. DOI: 10.20996/1819-6446-2010-6-5-747-748

3. Tyurin V.P. Infective endocarditis. -M.: GEOTAR-Media;2013. –358p. ISBN 978-5-9704-2554-1

4. Cahill TJ, Prendergast BD. Infective endocarditis. The Lancet. 2016;387(10021):882–93. DOI: 10.1016/S0140-6736(15)00067-7

5. Cahill TJ, Baddour LM, Habib G, Hoen B, Salaun E, Pettersson GB et al. Challenges in Infective Endocarditis. Journal of the American College of Cardiology. 2017;69(3):325–44. DOI: 10.1016/j. jacc.2016.10.066

6. Cahill TJ, Dayer M, Prendergast B, Thornhill M. Do patients at risk of infective endocarditis need antibiotics before dental procedures? BMJ. 2017;358:j3942. DOI: 10.1136/bmj.j3942

7. Garg P, Ko DT, Bray Jenkyn KM, Li L, Shariff SZ. Infective Endocarditis Hospitalizations and Antibiotic Prophylaxis Rates Before and After the 2007 American Heart Association Guideline Revision. Circulation. 2019;140(3):170–80. DOI: 10.1161/CIRCULATIONAHA.118.037657

8. Belov B.S., Tarasova G.M. Antibacterial therapy and prophylaxis for infective endocarditis in in present-day conditions. Effective pharmacotherapy. 2019;15(8):52–8.

9. Tran HM, Truong VT, Ngo TMN, Bui QPV, Nguyen HC, Le TTQ et al. Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam. PLOS ONE. 2017;12(12):e0189421. DOI: 10.1371/journal. pone.0189421

10. Ponomareva E.Yu., Landfang S.V. Analysis of hospital mortality in infective endocarditis. Fundamental Research. 2015;1(6):1222–5.

11. Cresti A, Chiavarelli M, Scalese M, Nencioni C, Valentini S, Guerrini F et al. Epidemiological and mortality trends in infective endocarditis, a 17-year population-based prospective study. Cardiovascular Diagnosis and Therapy. 2017;7(1):27–35. DOI: 10.21037/cdt.2016.08.09

12. Sunder S, Grammatico-Guillon L, Lemaignen A, Lacasse M, Gaborit C, Boutoille D et al. Incidence, characteristics, and mortality of infective endocarditis in France in 2011. PLOS ONE. 2019;14(10):e0223857. DOI: 10.1371/journal.pone.0223857

13. Shah ASV, McAllister DA, Gallacher P, Astengo F, Rodríguez Pérez JA, Hall J et al. Incidence, Microbiology, and Outcomes in Patients Hospitalized With Infective Endocarditis. Circulation. 2020;141(25):2067– 77. DOI: 10.1161/CIRCULATIONAHA.119.044913

14. Bin Abdulhak AA, Baddour LM, Erwin PJ, Hoen B, Chu VH, Mensah GA et al. Global and Regional Burden of Infective Endocarditis, 1990–2010: A Systematic Review of the Literature. Global Heart. 2014;9(1):131–43. DOI: 10.1016/j.gheart.2014.01.002

15. Thornhill MH, Jones S, Prendergast B, Baddour LM, Chambers JB, Lockhart PB et al. Quantifying infective endocarditis risk in patients with predisposing cardiac conditions. European Heart Journal. 2018;39(7):586–95. DOI: 10.1093/eurheartj/ehx655

16. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. Bennett JE, Dolin R, Blaser MJ, editors -Philadelphia, PA: Elsevier/Saunders;2015. - 3094 p. ISBN 978-1-4557-4801-3

17. Cahill T, Jewell P, Denne L, Franklin R, Frigiola A, Orchard E et al. Contemporary epidemiology of infective endocarditis in patients with congenital heart disease: A UK prospective study. American Heart Journal. 2019;215:70–7. DOI: 10.1016/j.ahj.2019.05.014

18. Hsiao C-C, Weng C-H, Li Y-J, Wu H-H, Chen Y-C, Chen Y-M et al. Comparison of the clinical features and outcomes of infective endocarditis between hemodialysis and non-hemodialysis patients. Therapeutics and Clinical Risk Management. 2017;13:663–8. DOI: 10.2147/TCRM.S135262

19. Strom BL, Abrutyn E, Berlin JA, Kinman JL, Feldman RS, Stolley PD et al. Risk Factors for Infective Endocarditis: Oral Hygiene and Nondental Exposures. Circulation. 2000;102(23):2842–8. DOI: 10.1161/01.CIR.102.23.2842

20. Demko I.V., Pelinovskaya L.I., Mankhayeva M.V., Ishchenko O.P., Mosina V.A., Kraposhina A.Yu. et al. Features of infective endocarditis in injection drug users. Russian Journal of Cardiology. 2019;24(6):97–102. DOI: 10.15829/1560-4071-2019-6-97-102

21. Rudasill SE, Sanaiha Y, Mardock AL, Khoury H, Xing H, Antonios JW et al. Clinical Outcomes of Infective Endocarditis in Injection Drug Users. Journal of the American College of Cardiology. 2019;73(5):559–70. DOI: 10.1016/j.jacc.2018.10.082

22. Gray ME, Rogawski McQuade ET, Scheld WM, Dillingham RA. Rising rates of injection drug use associated infective endocarditis in Virginia with missed opportunities for addiction treatment referral: a retrospective cohort study. BMC Infectious Diseases. 2018;18(1):532. DOI: 10.1186/s12879-018-3408-y

23. Taradin G.G., Vatutin N.T., Prendergast B.D., Newton J.D., Chaus E.A., Smyrnova A.S. Infective endocarditis in the elderly: The current view of the problem. Therapeutic Archive. 2016;88(11):128–37. DOI: 10.17116/terarkh20168811128-137

24. Østergaard L, Mogensen UM, Bundgaard JS, Dahl A, Wang A, TorpPedersen C et al. Duration and complications of diabetes mellitus and the associated risk of infective endocarditis. International Journal of Cardiology. 2019;278:280–4. DOI: 10.1016/j.ijcard.2018.09.106

25. Fernández-Cruz A, Muñoz P, Sandoval C, Fariñas C, GutiérrezCuadra M, Pericás Pulido JM et al. Infective endocarditis in patients with cancer: a consequence of invasive procedures or a harbinger of neoplasm? A prospective, multicenter cohort. Medicine. 2017;96(38):e7913. DOI: 10.1097/MD.0000000000007913

26. Dayer M, Thornhill M. Is antibiotic prophylaxis to prevent infective endocarditis worthwhile? Journal of Infection and Chemotherapy. 2018;24(1):18–24. DOI: 10.1016/j.jiac.2017.10.006

27. Peterson GE, Crowley AL. Antibiotic Prophylaxis for Infective Endocarditis: A Pound of Prevention and an Ounce of Cure. Circulation. 2019;140(3):181–3. DOI: 10.1161/CIRCULATIONAHA.119.041085

28. Lewis T, Grant RT. Observations relating to subacute infective endocarditis. Heart. 1923;10:21–77

29. Thomas CB, France R, Reichsman F. The prophylactic use of sulfanilamide: in patients susceptible to rheumatic fever. Journal of the American Medical Association. 1941;116(7):551–60. DOI: 10.1001/jama.1941.02820070001001

30. Jones TD, Baumgartner L, Bellows MT, Breese BB, Kuttner AG, McCarty M et al. Prevention of rheumatic fever and bacterial endocarditis through control of streptococcal infections. Circulation. 1955;11:317–20

31. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M et al. Prevention of Infective Endocarditis: Guidelines From the American Heart Association: A Guideline From the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116(15):1736– 54. DOI: 10.1161/CIRCULATIONAHA.106.183095

32. Thuny F, Grisoli D, Cautela J, Riberi A, Raoult D, Habib G. Infective endocarditis: prevention, diagnosis, and management. The Canadian Journal of Cardiology. 2014;30(9):1046–57. DOI: 10.1016/j.cjca.2014.03.042

33. Richey R, Wray D, Stokes T, Guideline Development Group. Prophylaxis against infective endocarditis: summary of NICE guidance. BMJ (Clinical research ed.). 2008;336(7647):770–1. DOI: 10.1136/ bmj.39510.423148.AD

34. Habib G, Hoen B, Tornos P, Thuny F, Prendergast B, Vilacosta I et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. European Heart Journal. 2009;30(19):2369–413. DOI: 10.1093/eurheartj/ehp285

35. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J-P, Del Zotti F et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). European Heart Journal. 2015;36(44):3075–128. DOI: 10.1093/eurheartj/ehv319

36. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease. The Journal of Thoracic and Cardiovascular Surgery. 2014;148(1):e1–132. DOI: 10.1016/j.jtcvs.2014.05.014

37. NICE. Prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional procedures. Clinical guideline [CG64]. 2008. [Internet] Available at: https://www.nice.org.uk/guidance/CG64

38. Danchin N, Duval X, Leport C. Prophylaxis of infective endocarditis: French recommendations 2002. Heart (British Cardiac Society). 2005;91(6):715–8. DOI: 10.1136/hrt.2003.033183

39. Duval X, Delahaye F, Alla F, Tattevin P, Obadia J-F, Le Moing V et al. Temporal Trends in Infective Endocarditis in the Context of Prophylaxis Guideline Modifications: three successive population-based surveys. Journal of the American College of Cardiology. 2012;59(22):1968–76. DOI: 10.1016/j.jacc.2012.02.029

40. DeSimone DC, Tleyjeh IM, Correa de Sa DD, Anavekar NS, Lahr BD, Sohail MR et al. Incidence of Infective Endocarditis Caused by Viridans Group Streptococci Before and After Publication of the 2007 American Heart Association’s Endocarditis Prevention Guidelines. Circulation. 2012;126(1):60–4. DOI: 10.1161/CIRCULATIONAHA.112.095281

41. DeSimone DC, Tleyjeh IM, Correa de Sa DD, Anavekar NS, Lahr BD, Sohail MR et al. Incidence of Infective Endocarditis Due to Viridans Group Streptococci Before and After the 2007 American Heart Association’s Prevention Guidelines: an extended evaluation of the Olmsted County, Minnesota, population and Nationwide Inpatient Sample. Mayo Clinic Proceedings. 2015;90(7):874–81. DOI: 10.1016/j.mayocp.2015.04.019

42. Pant S, Patel NJ, Deshmukh A, Golwala H, Patel N, Badheka A et al. Trends in Infective Endocarditis Incidence, Microbiology, and Valve Replacement in the United States From 2000 to 2011. Journal of the American College of Cardiology. 2015;65(19):2070–6. DOI: 10.1016/j.jacc.2015.03.518

43. Thornhill MH, Dayer MJ, Forde JM, Corey GR, Chu VH, Couper DJ et al. Impact of the NICE guideline recommending cessation of antibiotic prophylaxis for prevention of infective endocarditis: before and after study. BMJ. 2011;342:d2392. DOI: 10.1136/bmj.d2392

44. Dayer MJ, Jones S, Prendergast B, Baddour LM, Lockhart PB, Thornhill MH. Incidence of infective endocarditis in England, 2000–13: a secular trend, interrupted time-series analysis. The Lancet. 2015;385(9974):1219–28. DOI: 10.1016/S0140-6736(14)62007-9

45. Cahill TJ, Harrison JL, Jewell P, Onakpoya I, Chambers JB, Dayer M et al. Antibiotic prophylaxis for infective endocarditis: a systematic review and meta-analysis. Heart. 2017;103(12):937–44. DOI: 10.1136/heartjnl-2015-309102

46. Keller K, von Bardeleben RS, Ostad MA, Hobohm L, Munzel T, Konstantinides S et al. Temporal Trends in the Prevalence of Infective Endocarditis in Germany Between 2005 and 2014. The American Journal of Cardiology. 2017;119(2):317–22. DOI: 10.1016/j.amjcard.2016.09.035

47. Van den Brink FS, Swaans MJ, Hoogendijk MG, Alipour A, Kelder JC, Jaarsma W et al. Increased incidence of infective endocarditis after the 2009 European Society of Cardiology guideline update: a nationwide study in the Netherlands. European Heart Journal - Quality of Care and Clinical Outcomes. 2016;3(2):141–7. DOI: 10.1093/ehjqcco/qcw039

48. Chen T-T, Yeh Y-C, Chien K-L, Lai M-S, Tu Y-K. Risk of Infective Endocarditis After Invasive Dental Treatments: Case-Only Study. Circulation. 2018;138(4):356–63. DOI: 10.1161/CIRCULATIONAHA.117.033131

49. Marra F, George D, Chong M, Sutherland S, Patrick DM. Antibiotic prescribing by dentists has increased: why? The Journal of the American Dental Association. 2016;147(5):320–7. DOI: 10.1016/j.adaj.2015.12.014

50. Mishutina O.L. Prophylaxis for infective endocarditis during dental procedures in high risk patients. Bulletin of Smolensk State Medical Academy. 2011;10(2):2–5.

51. Suda KJ, Calip GS, Zhou J, Rowan S, Gross AE, Hershow RC et al. Assessment of the Appropriateness of Antibiotic Prescriptions for Infection Prophylaxis Before Dental Procedures, 2011 to 2015. JAMA Network Open. 2019;2(5):e193909. DOI: 10.1001/jamanetworkopen.2019.3909

52. Anguita P, Anguita M, Castillo JC, Gámez P, Bonilla V, Herrera M. Are Dentists in Our Environment Correctly Following the Recommended Guidelines for Prophylaxis of Infective Endocarditis? Revista Española de Cardiología (English Edition). 2019;72(1):86–8. DOI: 10.1016/j.rec.2018.04.029

53. Löffler C, Böhmer F, Hornung A, Lang H, Burmeister U, Podbielski A et al. Dental care resistance prevention and antibiotic prescribing modification—the cluster-randomised controlled DREAM trial. Implementation Science. 2014;9(1):27. DOI: 10.1186/1748-5908-9-27

54. Thornhill MH, Dayer MJ, Prendergast B, Baddour LM, Jones S, Lockhart PB. Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis: Figure 1. Journal of Antimicrobial Chemotherapy. 2015;70(8):2382–8. DOI: 10.1093/jac/dkv115

55. Cloitre A, Duval X, Hoen B, Alla F, Lesclous P. A nationwide survey of French dentists’ knowledge and implementation of current guidelines for antibiotic prophylaxis of infective endocarditis in patients with predisposing cardiac conditions. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2018;125(4):295–303. DOI: 10.1016/j.oooo.2017.10.002

56. Silva Conde I, Torres-Saura F, Alperi García A, de la Hera Galarza JM. Prophylaxis of Infective Endocarditis in Dentistry: Analysis of the Situation After Almost a Decade of Clinical Practice Guidelines. Revista Española de Cardiología (English Edition). 2019;72(1):95. DOI: 10.1016/j.rec.2018.07.013

57. Harken DE, Soroff HS, Taylor WJ, Lefemine AA, Gupta SK, Lunzer S. Partial and complete prostheses in aortic insufficiency. The Journal of Thoracic and Cardiovascular Surgery. 1960;40:744–62. PMID: 13711583

58. de Oliveira JC, Martinelli M, Nishioka SAD, Varejão T, Uipe D, Pedrosa AAA et al. Efficacy of Antibiotic Prophylaxis Before the Implantation of Pacemakers and Cardioverter-Defibrillators: Results of a Large, Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial. Circulation: Arrhythmia and Electrophysiology. 2009;2(1):29–34. DOI: 10.1161/CIRCEP.108.795906

59. Carrasco F, Anguita M, Ruiz M, Castillo JC, Delgado M, Mesa D et al. Clinical features and changes in epidemiology of infective endocarditis on pacemaker devices over a 27-year period (1987–2013). Europace. 2016;18(6):836–41. DOI: 10.1093/europace/euv377

60. Klug D, Lacroix D, Savoye C, Goullard L, Grandmougin D, Hennequin JL et al. Systemic Infection Related to Endocarditis on Pacemaker Leads: Clinical Presentation and Management. Circulation. 1997;95(8):2098–107. DOI: 10.1161/01.CIR.95.8.2098

61. Habib G, Erba PA, Iung B, Donal E, Cosyns B, Laroche C et al. Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. European Heart Journal. 2019;40(39):3222–32. DOI: 10.1093/eurheartj/ehz620

62. Prendergast BD, Redwood SR. Transcatheter Aortic Valve Replacement: New Gold Standard for the Treatment of Aortic Stenosis. Circulation. 2019;139(24):2724–7. DOI: 10.1161/CIRCULATIONAHA.119.040016

63. Chourdakis E, Koniari I, Hahalis G, Kounis NG, Hauptmann KE. Endocarditis after transcatheter aortic valve implantation: a current assessment. Journal of Geriatric Cardiology. 2018;15(1):61–5. DOI: 10.11909/j.issn.1671-5411.2018.01.003

64. Bjursten H, Rasmussen M, Nozohoor S, Götberg M, Olaison L, Rück A et al. Infective endocarditis after transcatheter aortic valve implantation: a nationwide study. European Heart Journal. 2019;40(39):3263–9. DOI: 10.1093/eurheartj/ehz588

65. Gallouche M, Barone-Rochette G, Pavese P, Bertrand B, Vanzetto G, Bouvaist H et al. Incidence and prevention of infective endocarditis and bacteraemia after transcatheter aortic valve implantation in a French university hospital: a retrospective study. Journal of Hospital Infection. 2018;99(1):94–7. DOI: 10.1016/j.jhin.2017.11.013

66. Butt JH, Ihlemann N, De Backer O, Søndergaard L, Havers-Borgersen E, Gislason GH et al. Long-Term Risk of Infective Endocarditis After Transcatheter Aortic Valve Replacement. Journal of the American College of Cardiology. 2019;73(13):1646–55. DOI: 10.1016/j.jacc.2018.12.078

67. Ahmad K, Klaaborg KE, Hjortdal V, Nørgaard BL, Terkelsen CJ, Jensen K et al. Prosthetic valve endocarditis after transcatheter aortic valve implantation-diagnostic and surgical considerations. Journal of Thoracic Disease. 2016;8(10):E1213–8. DOI: 10.21037/jtd.2016.10.28

68. Albes JM. Current practice in prophylaxis of endocarditis: are we running into trouble? European Journal of Cardio-Thoracic Surgery. 2019;56(1):1–6. DOI: 10.1093/ejcts/ezz151

69. Pippi R. Antibiotic prophylaxis for infective endocarditis: some rarely addressed issues. British Dental Journal. 2017;222(8):583–7. DOI: 10.1038/sj.bdj.2017.356

70. Walter J, Noll I, Feig M, Weiss B, Claus H, Werner G et al. Decline in the proportion of methicillin resistance among Staphylococcus aureus isolates from non-invasive samples and in outpatient settings, and changes in the co-resistance profiles: an analysis of data collected within the Antimicrobial Resistance Surveillance Network, Germany 2010 to 2015. BMC Infectious Diseases. 2017;17(1):169. DOI: 10.1186/s12879-017-2271-6

71. Mori M, Shioda K, Nguemeni Tiako MJ, Bin Mahmood SU, Mangi AA, Yun JJ et al. Comparable perioperative outcomes and mid-term survival in prosthetic valve endocarditis and native valve endocarditis. European Journal of Cardio-Thoracic Surgery. 2018;54(6):1067–72. DOI: 10.1093/ejcts/ezy191

72. Luciani N, Mossuto E, Ricci D, Luciani M, Russo M, Salsano A et al. Prosthetic valve endocarditis: predictors of early outcome of surgical therapy. A multicentric study. European Journal of Cardio-Thoracic Surgery. 2017;52(4):768–74. DOI: 10.1093/ejcts/ezx169

73. Leone S, Ravasio V, Durante-Mangoni E, Crapis M, Carosi G, Scotton PG et al. Epidemiology, characteristics, and outcome of infective endocarditis in Italy: the Italian Study on Endocarditis. Infection. 2012;40(5):527–35. DOI: 10.1007/s15010-012-0285-y

74. Farrington DK, Kilgo PD, Thourani VH, Jacob JT, Steinberg JP. High Risk of Prosthetic Valve Endocarditis and Death After Valve Replacement Operations in Dialysis Patients. The Annals of Thoracic Surgery. 2016;101(6):2217–23. DOI: 10.1016/j.athoracsur.2015.11.017

75. Prendergast BD. The changing face of infective endocarditis. Heart. 2006;92(7):879–85. DOI: 10.1136/hrt.2005.067256

76. Falcone M, Tiseo G, Durante-Mangoni E, Ravasio V, Barbaro F, Ursi MP et al. Risk Factors and Outcomes of Endocarditis Due to Non-HACEK Gram-Negative Bacilli: Data from the Prospective Multicenter Italian Endocarditis Study Cohort. Antimicrobial Agents and Chemotherapy. 2018;62(4):e02208-17. DOI: 10.1128/AAC.02208-17


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For citations:


Taradin G.G., Vatutin N.T., Ignatenko G.A., Ponomareva E.J., Prendergast B.D. Antibiotic prophylaxis for infective endocarditis: current approaches. Kardiologiia. 2020;60(12):117-124. (In Russ.) https://doi.org/10.18087/cardio.2020.12.n886

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