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The Distinguish Method of Severe Aortic Stenosis Treatment Geriatric High Mortality Risk Patients

https://doi.org/10.18087/cardio.2020.4.n864

Abstract

Aim To improve quality of treatment for senile patients with pronounced aortic stenosis (AS).
Material and methods Aortic valve stenosis (AS) is the most common valve pathology in cardiosurgical patients. Surgical correction of aortic valve (AV) stenosis accounts for 10 to 22 % of open-heart operations. 125 patients with pronounced AS were treated in the N. N. Burdenko Main Military Clinical Hospital between 2010 and 2017. This study was based on the implementation of new, minimally invasive methods in our clinic in 2013: balloon aortic valvuloplasty (BAVP) of the aortic valve and transcatheter aortic valve prosthesis (TCAVP).
Results In the group of patients receiving the drug therapy alone, the in-hospital mortality was 2 %. At the time of maximum follow-up duration (3 years), the survival rate was 50.5 %. In the group of patients who underwent the AV replacement with extracorporeal circulation, the 3 year postoperative mortality was 16.6 %. There was no 3 year mortality in the group of patients who underwent TCAVP. The short-term beneficial effect of BAVP was confirmed.
Conclusion An algorithm was developed for medical care of patients older than 75 with pronounced AS; the place of BAVP in the step-by-step management of these patients was determined. Using the developed approach in the management of these patients provided a 32 % (p<0.05) increase in the number of cases of radical surgical care.

About the Authors

E. V. Kryukov
N.N.Burdenko Main Clinical Military Hospital
Russian Federation
Academician of Russian Academy of Sciences MD, PhD, DSc Head of N.N.Burdenko Main Clinical Military Hospital


D. L. Kranin
N.N.Burdenko Main Clinical Military Hospital
Russian Federation
MD, PhD, DSc Head of Center of cardiovascular surgery N.N.Burdenko Main Clinical Military Hospital


A. V. Gajdukov
N.N.Burdenko Main Clinical Military Hospital
Russian Federation
Head of interventional and diagnostic radiology dept. N.N.Burdenko Main Clinical Military Hospital


A. Yu. Fedorov
N.N.Burdenko Main Clinical Military Hospital
Russian Federation
MD, PhD, Head of operating dept. N.N.Burdenko Main Clinical Military Hospital


D. A. Nazarov
N.N.Burdenko Main Clinical Military Hospital
Russian Federation
MD, PhD, Cardiac Surgeon of cardiosurgery dept. N.N.Burdenko Main Clinical Military Hospital


K. S. Zamckiy
N.N.Burdenko Main Clinical Military Hospital
Russian Federation
MD, PhD, Head of angiosurgery dept. N.N.Burdenko Main Clinical Military Hospital


K. A. Varochkin
N.N.Burdenko Main Clinical Military Hospital SPIN: 2701-5403
Russian Federation
Cardiac Surgeon of cardiosurgery dept. N.N.Burdenko Main Clinical Military Hospital


References

1. Mathers CD, Iburg KM, Salomon JA, Tandon A, Chatterji S, Ustün B et al. Global patterns of healthy life expectancy in the year 2002. BMC Public Health. 2004;4 (1):66. DOI: 10.1186/1471 2458 4 66

2. Spitzer E, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands, Cardialysis, Clinical Trial Management and Core Laboratories, Rotterdam, the Netherlands, Hahn RT, New York Presbyterian Hospital / Columbia University Medical Center, New York, NY, US, Cardiovascular Research Foundation, New York, NY, US et al. Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials. Cardiac Failure Review. 2019;5 (2):99–105. DOI: 10.15420/cfr.2018.41.2

3. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ et al. 2017 ESC / EACTS Guidelines for the management of valvular heart disease. European Heart Journal. 2017;38 (36):2739–91. DOI: 10.1093/eurheartj ehx391

4. Sadée AS, Becker AE, Verheul JA. The congenital bicuspid aortic valve with post-inflammatory disease – a neglected pathological diagnosis of clinical relevance. European Heart Journal. 1994;15 (4):503–6. DOI: 10.1093/oxfordjournals.eurheartj.a060534

5. Dzemischkevich S. L. Aortic valve defects in adults: current pathology and indications for surgery. Atmosphera. Cardiology. 2003;2:2–4. [Russian: Дземешкевич С. Л. Пороки аортального клапана у взрослых: современная патология и показания к операции. Атмосфера. Кардиология. 2003;2:2–4]

6. Roberts WC, Ewy GA, Glancy DL, Marcus FI. Valvular Stenosis Produced by Active Infective Endocarditis. Circulation. 1967;36 (3):449–51. DOI: 10.1161/01. CIR.36.3.449

7. Roberts WC, Ferrans VJ, Levy RI, Fredrickson DS. Cardiovascular pathology in hyperlipoproteinemia: anatomic observations in necropsy patients with normal or abnormal lipoprotein patterns. The American Journal of Cardiology. 1973;31 (5):557–70. DOI: 10.1016/0002–9149 (73) 90323–8

8. Pritzker MR. Acquired Aortic Stenosis in Systemic Lupus Erythematosus. Annals of Internal Medicine. 1980;93 (3):434. DOI: 10.7326/0003 4819 93 3 434

9. Fischer TA, Lehr H-A, Nixdorff U, Meyer J. Combined aortic and mitral stenosis in mucopolysaccharidosis type I-S (Ullrich-Scheie syndrome). Heart. 1999;81 (1):97–9. DOI: 10.1136/hrt.81.1.97

10. Cardiovascular pathology. Silver MD, editor -New York: Churchill Livingstone;1983. – 599–618 p. [Obstruction to blood flow related to the aortic valve]. ISBN 978 0 443 08049 4

11. Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS et al. Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency. Cell. 2015;160 (6):1072–86. DOI: 10.1016/j.cell.2015.02.035

12. Laforest B, Andelfinger G, Nemer M. Loss of Gata5 in mice leads to bicuspid aortic valve. Journal of Clinical Investigation. 2011;121 (7):2876–87. DOI: 10.1172/JCI44555

13. Nour D, Allahwala U, Hansen T, Muthukrishna N, Choong C, Hansen P et al. Comparison of Aortic Gradient Assessment Modalities in Balloon Aortic Valvuloplasty; is there a Correlation Between Echocardiograpic and Invasively Obtained Aortic Gradients? Heart, Lung and Circulation. 2019;28: S390. DOI: 10.1016/j.hlc.2019.06.595

14. Kryukov E. V., Chernetsov V. A., Kranin D. L., Gaydukov A. V., Nazarov D. A., Fedorov A. Yu. et al. First experience of transcatheter aortic valve implantation in medical center in Russia. Bulletein of Pirogov national medical and surgical center. 2017;12 (1):21–4. [Russian: Крюков Е. В., Чернецов В. А., Кранин Д. Л., Гайдуков А. В., Назаров Д. А., Федоров А. Ю. и др. Первый опыт транскатетерной имплантации аортального клапана в многопрофильном лечебном учреждении. Вестник Национального медико-хирургического центра им Н. И. Пирогова. 2017;12 (1):21–4]

15. Molchanov A. N., Romashkin V. V., Urvantseva I. A. Long-term results of surgical treatment of aortic defects in elderly patients. Ulyanovsk Medico-biological Journal. 2019;2:57–65. [Russian: Молчанов А. Н., Ромашкин В. В., Урванцева И. А. Оценка отдаленных результатов хирургического лечения аортальных пороков у пациентов старшего возраста. Ульяновский медико-биологический журнал. 2019;2:57–65]. DOI: 10.34014/2227 1848 2019 2 57 65

16. Kamenskaya O. V., Loginova I. Yu., Kretov E. I., Prokhorikhin A. A., Tarkova A. R., Baystrukov V. I. et al. Efficiency of transcatheter aortic valve implantation in patients with high surgical risk: long-term results of a single-center prospective study. Russian Journal of Cardiology. 2019;24 (1):56–61. [Russian: Каменская О. В., Логинова И. Ю., Кретов Е. И., Прохорихин А. А., Таркова А. Р., Байструков В. И. и др. Эффективность транскатетерной имплантации аортального клапана у пациентов высокого хирургического риска: отдаленные результаты одноцентрового проспективного исследования. Российский кардиологический журнал. 2019;24 (1):56–60]. DOI: 10.15829/1560 4071 2019 1 56 61

17. Popma JJ, Deeb GM, Yakubov SJ, Mumtaz M, Gada H, O’Hair D et al. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients. New England Journal of Medicine. 2019;380 (18):1706–15. DOI: 10.1056/NEJMoa1816885

18. Jones DR, Chew DP, Horsfall MJ, Chuang AM, Sinhal AR, Joseph MX et al. Effect of Balloon Aortic Valvuloplasty on Mortality in Patients with Severe Aortic Stenosis Prior to Conservative Treatment and Surgical or Transcatheter Aortic Valve Replacement. Heart, Lung and Circulation. 2019; S1443–9506 (19) 31327–7. [Epub ahead of print]. DOI: 10.1016/j.hlc.2019.06.717


Review

For citations:


Kryukov E.V., Kranin D.L., Gajdukov A.V., Fedorov A.Yu., Nazarov D.A., Zamckiy K.S., Varochkin K.A. The Distinguish Method of Severe Aortic Stenosis Treatment Geriatric High Mortality Risk Patients. Kardiologiia. 2020;60(4):43-47. https://doi.org/10.18087/cardio.2020.4.n864

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