Analysis of cardiovascular safety of novel glucose-lowering medications
https://doi.org/10.18087/cardio.2019.7.10267
Abstract
In 2008 the Food and Drug Administration has revised approval process for new antidiabetic agents and introduced a requirement to demonstrate the cardiovascular safety in an international multicenter trial. Currently cardiovascular outcome trials of dipeptidyl peptidase-4 (DPP-4) inhibitors (SAVOR-TIMI53, EXAMINE and TECOS), sodium-glucose cotransporter 2 inhibitors (EMPAREG, CANVAS), glucagon-like peptide-1 receptor agonists (ELIXA, EXSCEL LEADER and SUSTAIN-6), ultralong-acting and insulin (DEVOTE) have been completed. The trials confirmed cardiovascular safety of these glucose-lowering medications, and in addition, EMPA-REG OUTCOME (empagliflozin), CANVAS (canagliflozin) and LEADER (liraglutide) have also demonstrated cardioprotective effect of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists. These data led to the changes of clinical guidelines for the management of type 2 diabetes.
About the Authors
A. M. Mkrtumyan
A. I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Moscow
Russian Federation
Moscow
T. N. Markova
A. I. Yevdokimov Moscow State University of Medicine and Dentistry; City Clinical Hospital №52, Moscow
Russian Federation
Russian Federation
Markova Tatyana N. – MD, professor.
Moscow
N. K. Mishchenko
A. I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Mkrtumyan A.M., Markova T.N., Mishchenko N.K. Analysis of cardiovascular safety of novel glucose-lowering medications. Kardiologiia. 2019;59(7):76-83. (In Russ.) https://doi.org/10.18087/cardio.2019.7.10267
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