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Possibilities of clinical use of ezetimibe Otrio (JSC “AKRIKHIN”, Russia) in patients with high and very high cardiovascular risk who have not reached the target values of lipid metabolism. Conclusion of the Board of experts

https://doi.org/10.18087/cardio.n581

Abstract

This Conclusion of the Board of experts is devoted to the analysis of the evidence base, the position in modern clinical guidelines, the efficacy and safety analysis as well as the options of combined therapy with statins and ezetimibe (Otrio, JSC “AKRIKHIN”) in various categories of patients in routine clinical practice in theRussian Federation. Cardiovascular diseases (CVD) continue to lead in the structure of morbidity and mortality inRussia. Hypercholesterolemia is one of the main modifiable risk factors for CVD. Administration of HMGCo-A-reductase inhibitors (statins) remains the basis for the prevention and treatment of the main complications of atherosclerosis, but the achievement of target levels of LDL–C on of statin monotherapy in Russian practice among different categories of risk does not exceed 50%. Proportion of patients (up to 12%) does not tolerate statin therapy, which requires the search for alternative therapies. To optimize the control of the level of LDL–C, combination therapy with statins and ezetimibe is used. Ezetimibe is an effective lipid-lowering drug, an inhibitor of intestinal absorption of cholesterol, which was investigated in many international and Russian studies, the results of which have demonstrated good tolerability, safety and efficacy (reduction of LDL–C levels by 18% in monotherapy). It was noted that the combined therapy with low/medium doses of statins and ezetimibe effectively reduces the level of LDL–C by 44–53%, which is comparable to the effect of high doses of statins and reduces CV risk in patients with CKD and ACS. Otrio (INN Ezetimib) tablets 10 mg ( JSC “AKRIKHIN”,Russia) has demonstrated bioequivalence to the original drug Ezetrol tablets 10 mg (Schering-plough Labo N. V,Belgium). Broad use of a new generic product Otrio in combination with different statins will significantly increase the frequency of achievement of target lipid levels in patients with high and very high CV risk, including patients with chronic renal failure, type 2 diabetes and in patients with high hypercholesterolemia (LDL–C > 5 mmol/l) and, ultimately, reduce the burden of CV disease and mortality in Russia. 

About the Authors

J. D. Kobalava
People’s Friendship University of Russia
Russian Federation

117198, Russia, Moscow, ul. Miklukho-Maklaya, 6, 



V. S. Gurevich
Saint-Petersburg State University; North-Western State Medical university n.a. I.I. Mechnikov
Russian Federation

Clinical-research center “Cardiology”, Department of Atherosclerosis of SPbU

199034, Russia, St Petersburg, Universitetskaya Emb., 11; 195067, Russia, St. Petersburg, Piskarevskij prosp., 47



A. M. Galyavich
Kazan State Medical University
Russian Federation
420012, Russian Federation, Republic of Tatarstan, Kazan, Butlerova Str., 49


A. I. Kaminnyi
National Medical Research Center of Cardiology, Department of atherosclerosis; Pirogov Russian National Research Medical University
Russian Federation
121552, Russia, Moscow, 3 Cherepkovskaya str., 15a, 117997, Moscow, Russia, Ostrovityanova str., 1


V. V. Kashtalap
Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University
Russian Federation
650002, Russia, Kemerovo, Sosnoviy blvd., 6; 650056, Russia, Kemerovo, Voroshilov str., 22a


V. Yu. Mareev
Medical scientific and educational center of Lomonosov Moscow state University
Russian Federation
119192, Russia, Moscow, Lomonosov Ave., 27, bld.10


A. V. Susekov
Academy of Postgraduate Medical Education
Russian Federation
125993, Russia, Moscow, Barrikadnaya str., 2/1, bld. 1


I. I. Shaposhnik
South-Ural State Medical University
Russian Federation
454092, Russia, Chelyabinsk, Vorovskogo str., 64


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Kobalava J.D., Gurevich V.S., Galyavich A.M., Kaminnyi A.I., Kashtalap V.V., Mareev V.Yu., Susekov A.V., Shaposhnik I.I. Possibilities of clinical use of ezetimibe Otrio (JSC “AKRIKHIN”, Russia) in patients with high and very high cardiovascular risk who have not reached the target values of lipid metabolism. Conclusion of the Board of experts. Kardiologiia. 2019;59(5S):47-57. (In Russ.) https://doi.org/10.18087/cardio.n581

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