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Improvement of outcomes in patients with recent acute coronary syndrome: the place of PCSK9 inhibitors. The Resolution of National Advisory Board

https://doi.org/10.18087/cardio.n308

Abstract

On April 9, 2018, the national advisory board “Improvement of outcomes in patients with recent ACS: the place of PCSK9 inhibitors” was held in Moscow. Leading Russian experts in the field of atherosclerosis and lipid-lowering treatment attended the board. The purpose of the Board was to determine the place of PCSK9 inhibitors in the improvement of outcomes in patients with recent (less than 1 year) acute coronary syndrome (ACS). During the Board, three major aspects of lipid-lowering treatment were discussed: 1) issues in reaching the target levels of LDL cholesterol in real clinical practice among patients with recent ACS; 2) the results of ODYSSEY OUTCOMES study and their role in the improvement of outcomes in patients with recent ACS; 3) treatment with PCSK9 inhibitors in the management of patients with recent (less than 1 year) ACS in everyday clinical practice, the role of lipid centers.

About the Authors

N. M. Akhmedzhanov
National Medical Research Center for Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Russian Federation
Moscow


N. N. Vezikova
Petrozavodsk State University
Russian Federation
Petrozavodsk


M. I. Voevoda
National Research Institute for Therapy and Preventive Medicine
Russian Federation
Novosibirsk


A. S. Galyavich
Kazan State Medical University
Russian Federation
Kazan


V. S. Gurevich
Saint-Petersburg State University; North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Saint-Petersburg


D. V. Duplyakov
Samara Region Clinical and Diagnostic Cardiology Centre
Russian Federation
Samara


M. V. Ezhov
National Medical Research Center for Cardiology of the Ministry of Healthcare of the Russian Federation
Russian Federation
Moscow


Yu. A. Karpov
National Medical Research Center for Cardiology of the Ministry of Healthcare of the Russian Federation
Russian Federation
Moscow


V. V. Kashtalap
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Kemerovo,


G. A. Konovalov
Clinical and Diagnostic Centre “Medsi”
Russian Federation
Moscow


O. G. Smolenskaya
Ural State Medical University
Russian Federation
Ekaterinburg


A. N. Yakovlev
Federal State Budgetary Institution “Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation
Russian Federation
Saint-Petersburg


References

1. Jernberg T, Hasvold P, Henriksson M, Hjelm H, Thuresson M, Janzon M. Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a longterm perspective. European Heart Journal. 2015;36(19):1163–70. DOI: 10.1093/eurheartj/ehu505

2. Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H et al. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. European Heart Journal. 2016;37(39):2999– 3058. DOI: 10.1093/eurheartj/ehw272

3. Reiner Ž, De Backer G, Fras Z, Kotseva K, Tokgözoglu L, Wood D et al. Lipid lowering drug therapy in patients with coronary heart disease from 24 European countries – Findings from the EUROASPIRE IV survey. Atherosclerosis. 2016;246:243–50. DOI: 10.1016/j.atherosclerosis.2016.01.018

4. Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ et al. American association of clinical endocrinologists and american college of endocrinology guidelines for management of dyslipidemia and prevention of cardiovascular disease. Endocrine Practice. 2017;23(Supplement 2):1–87. DOI: 10.4158/EP171764.APPGL

5. Nanchen D, Gencer B, Auer R, Räber L, Stefanini GG, Klingenberg R et al. Prevalence and management of familial hypercholesterolaemia in patients with acute coronary syndromes. European Heart Journal. 2015;36(36):2438–45. DOI: 10.1093/eurheartj/ehv289

6. Ezhov M.V., Lazareva N.V., Sagaydak O.V., Vygodin V.A., Chubykina U.V., Bliznyuk S.A. et al. Prevalence of Dyslipidemia and Statins Use In Russian Acute Coronary Syndrome Registry. Atherosclerosis and Dyslipidemias. 2018;1:47–57. [Russian]

7. Tonelli M, Wanner C. Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline. Annals of Internal Medicine. 2014;160(3):182–9. DOI: 10.7326/M13-2453

8. Serban M-C, Colantonio LD, Manthripragada AD, Monda KL, Bittner VA, Banach M et al. Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction. Journal of the American College of Cardiology. 2017;69(11):1386–95. DOI: 10.1016/j.jacc.2016.12.036

9. Schwartz GG, Bessac L, Berdan LG, Bhatt DL, Bittner V, Diaz R et al. Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial. American Heart Journal. 2014;168(5):682-689.e1. DOI: 10.1016/j. ahj.2014.07.028

10. Schwartz GG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R et al. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. New England Journal of Medicine. 2018;379(22):2097– 107. DOI: 10.1056/NEJMoa1801174

11. Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. New England Journal of Medicine. 2015;372(25):2387–97. DOI: 10.1056/NEJMoa1410489

12. Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA et al. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. New England Journal of Medicine. 2017;376(18):1713–22. DOI: 10.1056/NEJMoa1615664

13. Annemans L, Packard CJ, Briggs A, Ray KK. ‘Highest risk–highest benefit’ strategy: a pragmatic, cost-effective approach to targeting use of PCSK9 inhibitor therapies. European Heart Journal. 2018;39(27):2546–50. DOI: 10.1093/eurheartj/ehx710

14. Landmesser U, Chapman MJ, Stock JK, Amarenco P, Belch JJF, Borén J et al. 2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia. European Heart Journal. 2018;39(14):1131–43. DOI: 10.1093/eurheartj/ehx549

15. Ezhov M.V., Sergienko I.V., Aronov D.M., Arabidze G.G., Akhmedzhanov N. M., Bazhan S.S. et al. Diagnostics and correction of lipid metabolism disorders for the prevention and treatment of atherosclerosis. Russian recommendations VI revision. Atherosclerosis and Dyslipidemias. 2017;3:5–22. [Russian]


Review

For citations:


Akhmedzhanov N.M., Vezikova N.N., Voevoda M.I., Galyavich A.S., Gurevich V.S., Duplyakov D.V., Ezhov M.V., Karpov Yu.A., Kashtalap V.V., Konovalov G.A., Smolenskaya O.G., Yakovlev A.N. Improvement of outcomes in patients with recent acute coronary syndrome: the place of PCSK9 inhibitors. The Resolution of National Advisory Board. Kardiologiia. 2019;59(5S):58-64. (In Russ.) https://doi.org/10.18087/cardio.n308

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ISSN 0022-9040 (Print)
ISSN 2412-5660 (Online)