Systematic Analysis of the Roles of Trace Elements in the Prevention and Treatment of Chronic Heart Failure
https://doi.org/10.18087/cardio.2019.6.n683
Abstract
Systematic analysis of 3 728 publications on the relationship between microelement status and chronic heart failure (CHF) was carried out. Three main areas of research have been identified: 1) magnesium, electrolytes and CHF; 2) the transcriptional and antioxidant effects of zinc, selenium, copper; 3) iron-deficiency anemia and CHF. In this paper, we consider a complex of relationships between the magnesium insufficiency and CHF, the effect of magnesium on vascular tone, mitochondria, heart rhythm and the susceptibility of cardiomyocytes to adrenergic stimulation. Using magnesium orotate for the treatment of CHF is a feasible approach to compensate magnesium insufficiency in patients with CHF.
About the Authors
O. A. Gromova
Federal Research Center for Informatics and Management;
Center for Big Data Storage and Analysis, Moscow State University
Russian Federation
Russian Federation
Gromova Olga A. – professor.
Moscow
I. Yu. Torshin
Federal Research Center for Informatics and Management;
Center for Big Data Storage and Analysis, Moscow State University
Russian Federation
Moscow
Russian Federation
Moscow
Zh. D. Kobalava
Moscow State University
Russian Federation
Moscow
Russian Federation
Moscow
A. G. Nazarenko
N. N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation
Moscow
Russian Federation
Moscow
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50. Gromova O.A., Torshin I.Yu., Kalacheva A.G., Grishina T.R., Egorova E.Yu. Regarding a Circadian Rhythm and Chronopharmacology of Magnesium Orotate. Effective pharmacotherapy. 2015;34:32–41. [Russian]
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52. Gromova O.A., Torshin I.Yu., Yudina N.V., Egorova E.Yu., Gromov A.N., Grishina T.R. Magnesium Deficiency and Dys regulation of Vascular Tone. Kardiologiia. 2014;54(7):66–72. [Russian]
53. Gao X, Wang M, He X, Tang L, Liang J, Peng L et al. Decreased intralymphocytic magnesium content is associated with diastolic heart dysfunction in patients with essential hypertension. International Journal of Cardiology. 2011;147(2):331–4. DOI: 10.1016/j.ijcard.2010.12.092
54. Dickinson HO, Nicolson D, Campbell F, Cook JV, Beyer FR, Ford GA et al. Magnesium supplementation for the management of primary hypertension in adults. Cochrane Database of Systematic Reviews. 2006;Jul 19(3):CD004640. DOI: 10.1002/14651858.CD004640.pub2
55. Jee SH, Miller ER, Guallar E, Singh VK, Appel LJ, Klag MJ. The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials. American Journal of Hypertension. 2002;15(8):691–6. PMID: 12160191
56. Gromova O.A., Torshin I.Yu., Rudakov K.V., Gromov A.N., Kalacheva A.G. Systematic Analysis of Magnesium Dependent Mitochondrial Proteins. Kardiologiia. 2014;54(9):86–92. [Russian]
57. Ahmed LA. Protective effects of magnesium supplementation on metabolic energy derangements in lipopolysaccharide-induced cardiotoxicity in mice. European Journal of Pharmacology. 2012;694(1–3):75–81. DOI: 10.1016/j.ejphar.2012.07.036
58. Di Lullo L, Rivera R, Barbera V, Bellasi A, Cozzolino M, Russo Det al. Sudden cardiac death and chronic kidney disease: From pathophysiology to treatment strategies. International Journal of Cardiology. 2016;217:16–27. DOI: 10.1016/j.ijcard.2016.04.170
59. Gil KE, Pawlak A, Gil RJ, Frontczak-Baniewicz M, Bil J. The role of invasive diagnostics and its impact on the treatment of dilated cardiomyopathy: A systematic review. Advances in Medical Sciences. 2016;61(2):331–43. DOI: 10.1016/j.advms.2016.07.001
60. Crippa G, Sverzellati E, Giorgi-Pierfranceschi M, Carrara GC. Magnesium and cardiovascular drugs: interactions and therapeutic role. Annali Italiani Di Medicina Interna: Organo Ufficiale Della Societa Italiana Di Medicina Interna. 1999;14(1):40–5. PMID: 10528423
61. Wang A. Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillation. Pharmacy Practice. 2012;10(2):65–71. PMID: 24155819
62. Coleman CI, Sood N, Chawla D, Talati R, Ghatak A, Kluger J et al. Intravenous magnesium sulfate enhances the ability of dofetilide to successfully cardiovert atrial fibrillation or flutter: results of the Dofetilide and Intravenous Magnesium Evaluation. Europace. 2009;11(7):892–5. DOI: 10.1093/europace/eup084
63. Tsukamoto T, Morita K, Naya M, Inubushi M, Katoh C, Nishijima K et al. Decreased Myocardial -Adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy. Journal of Nuclear Medicine. 2007;48(11):1777–82. DOI: 10.2967/jnumed.107.043794
64. Jin Y-T, Hasebe N, Matsusaka T, Natori S, Ohta T, Tsuji S et al. Magnesium attenuates isoproterenol-induced acute cardiac dysfunction and β-adrenergic desensitization. American Journal of Physiology-Heart and Circulatory Physiology. 2007;292(3):H1593–9. DOI: 10.1152/ajpheart.00985.2006
65. Wu Y-S, Chen C-C, Chien C-L, Lai H-L, Jiang S-T, Chen Y-C et al. Th type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA TAT3-dependent pathway. Journal of Biomedical Science. 2017;24(1):68. DOI: 10.1186/s12929-017-0367-3
66. Gromova O.A., Torshin I.Yu., Yurgel’ I.S. Retrospective of pharmacokinetic studies of magnesium preparations. Difficult patient. 2009;7(6–7):42–6. [Russian]
67. Torshin I.Yu., Gromova O.A. Molecular mechanisms of action of magnesium orotate on cardiovascular system. Rational Pharmacotherapy in Cardiology. 2008;4(5):63–6. [Russian]
68. Torshin I.Yu., Gromova O.A., Fedotova L.E., Kalacheva A.G., Gromov A.N., Rudakov K.V. Ghemoinformational analysis molecule of orotic acid indicates anti-inflammatory, neuroprotective and cardioprotective properties of the ligand of magnesium. Pharmateca. 2013;13(266):95–104. [Russian]
69. Jasmin G, Proschek L. Effect of orotic acid and magnesium orotate on the development and progression of the UM-X7.1 hamster hereditary cardiomyopathy. Cardiovascular Drugs and Therapy. 1998;12(Suppl 2):189–95. PMID: 9794093
70. Torshin I.Yu., Gromova O.A., Kalacheva A.G., Oshchepkova E.V., Martynov A.I. Meta-analysis of clinical trials of cardiovascular effects of magnesium orotate. Therapeutic Archive. 2015;87(6):88–97. [Russian]. DOI: 10.17116/terarkh201587688-97
71. Stepura OB, Martynow AI. Magnesium orotate in severe congestive heart failure (MACH). International Journal of Cardiology. 2009;131(2):293–5. DOI: 10.1016/j.ijcard.2007.11.022
72. Gromova O.A., Torshin I.Yu., Kalacheva A.G., Grishina T.R., Egorova E.Yu. Regarding a Circadian Rhythm and Chronopharmacology of Magnesium Orotate. Effective pharmacotherapy. 2015;34:32–41. [Russian]
Review
For citations:
Gromova O.A., Torshin I.Yu., Kobalava Zh.D., Nazarenko A.G. Systematic Analysis of the Roles of Trace Elements in the Prevention and Treatment of Chronic Heart Failure. Kardiologiia. 2019;59(6):26-34. (In Russ.) https://doi.org/10.18087/cardio.2019.6.n683
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