Epicardial Transplantation of Cardiac Progenitor Cells Based Cells Sheets is More Promising Method for Stimulation of Myocardial Regeneration, Than Conventional Cell Injections
https://doi.org/10.18087/cardio.2019.5.2597
Abstract
Today, transplantation of stem / progenitor cells is a promising approach for the treatment of heart diseases. The therapeutic potential of transplanted cells directly depends on the method of delivery to the myocardium, which determines their regenerative properties. It is important for the development of effective methods of cell therapy. In this paper, we performed a comparative study of efficacy of cardiac progenitor cell (CPC) transplantation by intramyocardial needle injections and by tissue engineering constructs (TEC) – “cell sheets” consisting of cells and their extracellular matrix. It has been shown, that transplantation of TEC in comparison with the intramyocardial delivery provides more extensive distribution and retains more proliferating cellular elements in the damaged myocardium, attenuates the negative cardiac remodeling of the left ventricle and promotes its vascularization.
About the Authors
K. V. Dergilev
National Medical Research Center for Cardiology
Russian Federation
Russian Federation
Dergilev Konstantin V. – MD, PhD, leading researcher
Moscow
Z. I. Tsokolayeva
National Medical Research Center for Cardiology
Russian Federation
Moscow
Russian Federation
Moscow
I. B. Beloglazova
National Medical Research Center for Cardiology
Russian Federation
Moscow
Russian Federation
Moscow
E. I. Ratner
National Medical Research Center for Cardiology
Russian Federation
Moscow
Russian Federation
Moscow
E. V. Parfyonova
National Medical Research Center for Cardiology;
Lomonosov Moscow State University
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Dergilev K.V., Tsokolayeva Z.I., Beloglazova I.B., Ratner E.I., Parfyonova E.V. Epicardial Transplantation of Cardiac Progenitor Cells Based Cells Sheets is More Promising Method for Stimulation of Myocardial Regeneration, Than Conventional Cell Injections. Kardiologiia. 2019;59(5):53-60. (In Russ.) https://doi.org/10.18087/cardio.2019.5.2597
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