Indapamide SR/Amlodipine Fixed Dose Combination: Novel Approach to Effective Control of Systolic Arterial Pressure

Effective control of arterial pressure (AP) is achieved only in У of patients with arterial hypertension. It is especially difficult to achieve control of systolic (S) AP in elderly patients in whom SAP is the strongest prognostic factor of cardiovascular complications. Thiazide and thiazide-like diuretics and calcium antagonists are effective for lowering of elevated SAP and pulse (P) AP including aortic PAP elevation of which is associated with high stiffness of arterial wall and is typical for elderly people. Combination of a thiazide diuretic and a calcium antagonist has been recommended by modern guidelines on arterial hypertension (AH) management but until recently it has not found wide application because of absence of a fixed preparation. Evidence base of indapamide-retard and amlodipine use in AH, their profiles of efficacy and safety are such that their combination can become an alternative variant for treatment of patients with AH. Appearance of a fixed indapamide-retard/amlodipine combination opens new perspectives of effective therapy of AH with high SAP and PAP in elderly and other patients with high stiffness of arterial wall.

индапамид-ретард, амлодипин, фиксированная комбинация, систолическое артериальное давление, артериальная ригидность, indapamide-retard, amlodipine, fixed combination, systolic blood pressure, arterial stiffness

1. Turnbull F. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet 2003;362:1527-1535.

2. Beckett N. S., Peters R., Fletcher A. E. et al. Treatment of hypertension in Patients 80 years of Age or Older. N. Engl J. Med 2008;358:1887-1898.

3. Collins R., Peto R. Antihypertensive drug therapy: effects on stroke and coronary heart disease. In: Swales J. D., eds. Textbook of Hypertension. Oxford, UK: Blackwell Scientific Publications. 1994;1156-1164.

4. Mohan V., Deepa M., Farooq S. et al. Prevalence, awareness and control of hypertension in Chennai - The Chennai Urban Rural Epidemiology Study (CURES-52). J. Assoc Physicians India 2007;55:326-332.

5. Tocci G., Rosei E. A., Ambrosioni E. et al. Blood pressure control in Italy: analysis of clinical data from 2005-2011 surveys on hypertension. J. Hypertens 2012;30:1065-1074.

6. Williams B., Lindholm L. H., Sever P. Systolic pressure is all that matters. Lancet 2008;371:2219-2221.

7. Vlachopoulos C., Aznaouridis K., Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiff ness: a systematic review and meta-analysis. J. Am Coll Cardiol 2010;55:1318-1327.

8. O'Rourke M. F. Isolated systolic hypertension, pulse pressure, and arterial stiffness as risk factors for cardiovascular disease. Curr Hypertens Rep 1999;1:204-211

9. Кобалава Ж. Д., Котовская Ю. В., Богомаз А. В. Фиксированная комбинация бисопролола и амлодипина нивелирует влияние β-адреноблокатора на показатели центральной пульсовой волны у больных артериальной гипертонией. Кардиология 2015;55 ( 12): 11-16). DOI: http://dx.doi.org/10.18565/cardio.2015.12.11-16]

10. von Arx R., Rexhaj E., Allemann Y. et al. Lack of blood pressure lowering effect of renal denervation in a drug-naive patient with pronounced arterial stiffening. Am J. Med 2014;127: e3-e4.

11. Aronow W. S., Fleg J. L., Pepine C.J. et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 2011;123:2434-2506.

12. Agnoletti D., Zhang Y., Borghi C. et al. Effects of antihypertensive drugs on central blood pressure in humans: a preliminary observation. Am J Hypertens 2013;26:1045-1052.

13. Mackenzie I. S., McEniery C. M., Dhakam Z. et al. Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension. Hypertension 2009;54:409-413.

14. Morgan T., Lauri J., Bertram D. et al. Effect of different antihypertensive drug classes on central aortic pressure. Am J Hypertens 2004;17:118-123.

15. Mancia G., Fagard R., Narkiewicz K. et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013;34:2159-2219.

16. Liu L., Zhang Y., Liu G. et al. The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens 2005;23:2157-2172.

17. Julius S., Kjeldsen S. E., Weber M. et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004;363:2022-2031.

18. Mulatero P., Verhovez A., Morello F., Veglio F. Diagnosis and treatment of low-renin hypertension. Clin Endocrinol (Oxf) (2007) 67:324-334.

19. Rimoldi S. F., Messerli F. H., Chavez P. et al. Efficacy and safety of calcium channel blocker / diuretics combination therapy in hypertensive patients: a meta-analysis. J Clin Hypertens (Greenwich) 2015;17 (3):193-9. doi: 10.1111/jch.12462.

20. Williams B., Lacy P. S., Thom S. M. et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006;113:1213-1225.

21. Baguet J. P., Legallicier B., Auquier P., Robitail S. Updated metaanalytical approach to the efficacy of antihypertensive drugs in reducing blood pressure. Clin Drug Invest 2007;27:735-753.

22. Akram J., Sheikh U. E., Mahmood M., Donnelly R. Antihypertensive efficacy of indapamide SR in hypertensive patients uncontrolled with a background therapy: the NATIVE study. Curr Med Res Opin 2007;23:2929-2936.

23. Weidmann P. Metabolic profile of indapamide sustained-release in patients with hypertension: data from three randomised doubleblind studies. Drug Safety 2001;24:1155-1165.

24. Ambrosioni E., Safar M., Degaute J. P. et al. Low-dose antihypertensive therapy with 1.5 mg sustained-release indapamide: results of randomised double- blind controlled studies. European study group. J Hypertens 1998;16:1677-1684.

25. Madkour H., Gadallah M., Riveline B. et al. Indapamide is superior to thiazide in the preservation of renal function in patients with renal insufficiency and systemic hypertension. Am J Cardiol 1996;77:23B - 25B.

26. Brennan L., Wu M.J., Laquer U.J. A multicenter study of indapamide in hypertensive patients with impaired renal function. Clin Ter 1982;5:121-128.

27. Papademetriou V., Burris J. F., Notargiacomo A. et al. Thiazide therapy is not a cause of arrhythmia in patients with systemic hypertension. Arch Intern Med 1988;148:1272-1276.

28. Jadhav U., Hiremath J., Namjoshi D.J. et al. Blood pressure control with a single-pill combination of indapamide sustained-release and amlodipine in patients with hypertension: the EFFICIENT study. PLoS ONE 2014;9: e92955.

29. van Vark L. C., Bertrand M., Akkerhuis K. M. et al. Angiotensinconverting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone- system inhibitors involving 158,998 patients. Eur Heart J 2012;33:2088-2097.

30. Hanon O., Boully C., Caillard L. et al. Treatment of Hypertensive Patients With Diabetes and Microalbuminuria With Combination Indapamide SR/Amlodipine: Retrospective Analysis of NESTOR. Am J Hypertens 2015;28 (8):1064-1071. doi: 10.1093/ ajh/hpu297.