Macrophages and Their Role in Destabilization of an Atherosclerotic Plaque
https://doi.org/10.18087/cardio.2019.4.10254
Abstract
The modern data on structure and the functional activity of macrophages are presented in the review. It is shown that they are the nonhomogeneous cell population. Two of their main subpopulations are presented as M1 and M2 phenotypes which perform opposite functions at inflammation development. The main attention in the review is paid to a role of macrophages in pathogenesis of atherosclerosis and, first, in formation of unstable atherosclerotic plaques which are the cause of the most severe complications of the disease. It is shown that main subpopulations of macrophages play different roles in formation of unstable and stable atherosclerotic plaques. Macrophages of M1 phenotype in the vascular wall carry out pro-atherogenic role and influence destabilization of an atherosclerotic plaque, while M2 macrophages perform atheroprotective function.
About the Authors
P. V. Pigarevsky
Institute of Experimental Medicine, St. Petersburg
Russian Federation
Russian Federation
Department of the General and Private Morphology
MD, ScD
V. A. Snegova
Institute of Experimental Medicine, St. Petersburg
Russian Federation
Russian Federation
P. G. Nazarov
Institute of Experimental Medicine, St. Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Pigarevsky P.V., Snegova V.A., Nazarov P.G. Macrophages and Their Role in Destabilization of an Atherosclerotic Plaque. Kardiologiia. 2019;59(4):88-91. (In Russ.) https://doi.org/10.18087/cardio.2019.4.10254
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