Decreased Heart Rate Variability in Sickle Cell Anemia as Effect of Pulmonary Arterial Hypertension
https://doi.org/10.18087/cardio.2019.4.10237
Abstract
Decreased heart rate variability (HRV) is associated with increased mortality risk in various diseases. The objective of this investigation:to study HRV in patients with sickle cell anemia (SCA) and to assess the effect of pulmonary arterial hypertension (PAH) on HRV in these patients. Materials and methods. HRV registration and Doppler echocardiographic assessment of systolic pulmonary arterial pressure (PAP) was carried out in 61 stable patients with SCA and 24 healthy subjects. Results. Low frequency power (LFP) and high frequency power (HFP) were decreased in SCA patients compared to healthy subjects. Among SCA patients, PAH patients had lower LFP and HFP than patients without PAH. In SCA patients, systolic PAP showed significant negative correlation with LFP and HFP. Conclusion. HRV is significantly decreased in SCA patients, especially in those with PAH. HRV may be particularly useful in early detection of PAH patients who may have worse prognosis and higher mortality risk.
About the Authors
F. Akgul
Bulent Ecevit University, Zonguldak
Turkey
Turkey
MD, professor
Cardiology Department
T. A. Batyraliev
Sanko University, Gaziantep
Turkey
Turkey
D. V. Fettser
City Clinical Hospital № 52, Moscow
Russian Federation
Russian Federation
E. Seyfeli
Mustafa Kemal University, Antakya
Turkey
Turkey
A. G. Arystan
Medical Centre Hospital of President’s Affairs Administration of the RK, Astana
Kazakhstan
Kazakhstan
T. Seydaliyeva
Mustafa Kemal University, Antakya
Turkey
Turkey
E. Gali
Antakya State Hospital, Antakya
Turkey
Turkey
F. Yalcin
Mustafa Kemal University, Antakya
Turkey
Turkey
B. A. Sidorenko
Central State Medical Academy, President Management Department RF
Russian Federation
Russian Federation
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Review
For citations:
Akgul F., Batyraliev T.A., Fettser D.V., Seyfeli E., Arystan A.G., Seydaliyeva T., Gali E., Yalcin F., Sidorenko B.A. Decreased Heart Rate Variability in Sickle Cell Anemia as Effect of Pulmonary Arterial Hypertension. Kardiologiia. 2019;59(4):39-44. (In Russ.) https://doi.org/10.18087/cardio.2019.4.10237
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