Blood Pressure Levels and Prevalence of Arterial Hypertension in the Population of Residents of the Central Region of Siberia Aged 25–45 Years

Purpose: to study blood pressure levels and the prevalence of hypertension in persons aged 25–45 years in Novosibirsk.

Materials and methods. A cross-sectional population study in one of typical areas of Novosibirsk was performed in 2013–2016. The study included 479 men and 612 women aged 25–45 years. Arterial hypertension was defined as blood pressure (BP) ≥140 / 90 mmHg according to Russian recommendations (2004). For analysis two age groups were distinguished: 25–34 years and 35–45 years.

Results. Mean values of systolic and diastolic BP were significantly lower in women than in men in age groups. In men and women, the analyzed indicators were significantly higher in the older than in the younger age group. Mean values of pulse pressure in men were significantly higher than in women in both age groups, there were no differences in the analyzed index between age groups in either men or women. Optimal BP was more often recorded among women than among men in both age groups. The proportion of persons with normal BP among men was grate than among women in both age groups. In the age group 35–45 years compared with the younger group, in men there was a decrease in incidence of category with BP<140 / 90 mmHg, an increase of the proportion of persons with hypertension grades 1 and 2, the appearance of persons with grade 3 hypertension; in women – an increase of the proportion of individuals with normal, high-normal BP, and with grade 1 hypertension, appearance of individuals with grades 2 and 3 hypertension. Frequency of BP categories ≥140 / 90 mmHg in age group 25–34 years among men was 17.6 %, among women 3.1 % (p<0.0001); in age group 35–45 years among men – 34.7 %, among women – 12.5 % (p<0.0001).

Conclusions. Prevalence of hypertension in men was 28 %, in women – 9 %. Favorable tendencies of BP indicators in both sexes were revealed over a 30-year period, while gender differences did not change.

1. Oksenojt G.K., Nikitina S.Yu. (Eds.).The Demographic Yearbook of Russia. 2015. Federal State Satistical Service. Moscow, 2015. Russian (Оксенойт Г.К., Никитина С.Ю. (Ред.). Демографический ежегодник России. 2015. Федеральная служба государственной статистики. М., 2015).

2. Nikitin Yu.P. (Ed.). Monitoring of cardiovascular morbidity, mortality and risk factors in different regions of the world (WHO MONICA PROJECT). Academic Publishing House Geo Limited, 2016. Russian (Никитин Ю.П. (Ред.). Мониторирование сердечно-сосудистой заболеваемости, смертности и их факто-ров риска в разных регионах мира (проект ВОЗ MONICA). Академическое издание «Гео» 2016:699 c).

3. Pereira M., Lunet N., Azevedo A., Barros H. Differences in prevalence, awareness, treatment and control of hypertension between developing and developed countries. J Hypertens 2009;27:963–975. doi.org/10.1097/hjh.0b013e3283282f65.

4. Mancia G., Fagard R., Narkiewicz K. et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013;34(28):2159–2219. doi. org/10.1093/eurheartj/eht151.

5. Cooper R.S. Using public health indicators to measure the success of hypertension control. Hypertension 2007;49:773–774. doi. org/10.1161/01.hyp.0000259106.77783.f.

6. Wolf-Maier K., Cooper R.S., Banegas J.R. et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada and the United States. JAMA 2003;289: 2363–2369.

7. Redon J., Olsen M.H., Cooper R.S. et al. Stroke mortality trends from 1990 to 2006 in 39 countries from Europe and Central Asia: implications for control of high blood pressure. Eur Heart J 2011;32:1424–1431. doi.org/10.1093/eurheartj/ehr045.

8. Vasan R.S., Larson M.G., Leip E.P. et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 2001;345:1291–97. doi.org/10.1056/nejmoa003417.

9. Bateman B.T., Shaw K.M., Kuklina E.V. et al. Hypertension in women of reproductive age in the United States: NHANES 1999–2008. PLoS One 2012;7(4):e36171. DOI: 10.1371/journal.pone.0036171.

10. Efremova Yu.E., Oshchepkova E.V., Zhernakova Yu.V. et al. Cardiovascular risk factors in people with high normal blood pressure in Russian population (based on data obtained in ESSE-RF epidemiological study). Systemic Hypertension 2017;14(1):6–11. DOI: 10.26442/2075-082X_14.1.6-11. Russian (Ефремова Ю.Е., Ощепкова Е.В., Жернакова Ю.В. и др. Факторы риска сердечно-сосудистых заболеваний у лиц с высоким нормальным артериальным давлением в Российской Федерации (по данным эпидемиологического исследования ЭССЕ-РФ). Системные гипертензии 2017;14(1):6–11).

11. Akimova Е.V., Akimov М.Yu., Gakova Е.I. et al. Prevalence associations of various risk factors and arterial hypertension in male open urban population (by a one stage epidemiological study). Russ J Cardiol 2018;23(9):7–11. doi.org/10.15829/1560-4071-2018-9-7-11. Russian (Акимова Е.В., Акимов М.Ю., Гакова Е.И. и др. Ассоциации распространенности некоторых психосоциальных факторов риска и артериальной гипертензии у мужчин откры-той городской популяции (по данным одномоментного эпидемиологического исследования). Российский кардиологический журнал. 2018;23(9):7–11).

12. Voevoda M.I., Kovalkova N.A., Ragino Yu.I. et al. Prevalence of metabolic syndrome in 25–45-year-old Novosibirsk dwellers. Terapevticheskii arkhiv 2016;88(10):51–57. doi.org/10.17116/ terarkh2016881051-56. Russian (Воевода М.И., Ковалькова Н.А., Рагино Ю.И. и др. Распространенность метаболического синдрома в популяции 25–45 лет г. Новосибирска. Терапевтический архив 2016;88(10):51–57).

13. Denisova D.V., Nikitin Yu.P., Shcherbakova L.V., Zavyalova L.G. Prevalence, trends and associations of arterial hypertension among adolescents (epidemiological study in Novosibirsk – 1989–2009). Atherosclerosis 2014;10 (2):37–42. Russian (Денисова Д.В., Никитин Ю.П., Щербакова Л.В., Завьялова Л.Г. Распространенность, тренды и ассоциации артериальной гипертензии среди подростков (популяционные исследования в Новосибирске, 1989–2009). Атеросклероз 2014;10(2):37–42).

14. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants. NCD Risk Factor. Collaboration (NCDRisC). Lancet 2017;389:37–55 2016. doi.org/10.1016/S0140-6736(16)31919-5.

15. Franklin S., Khan S.,Wong N.D. et al. Is pulse pressure useful in predicting risk of coronary heart-disease? The Framingham Study. Circulation 1999;100:354–360. doi.org/10.1161/01.cir.100.4.354.

16. de Simone G., Kitzman D.W. Chinali M. et al. Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study. Eur Heart J 2005;26:1039–1045. DOI: 10.1093/eurheartj/ehi019.