The Role of Smooth Myocytes and Macrophages in Development of Complicated Forms of Arterial Atherosclerosis
https://doi.org/10.18087/cardio.2019.1.10207
Abstract
Purpose: to conduct morphohistochemical and immunohistochemical study of arterial unstable atherosclerotic plaques for assessment of the state of smooth muscle cells (SMC) and macrophages.
Materials and methods. The surgical material of the peripheral arteries (femoral, popliteal, external carotid) was obtained from 50 patients aged over 60 years, followed by morphohistochemical, immunohistochemical studies.
Results. Hyperplasia of secretory smooth muscle cells (SMC), and new formation of thin-walled capillary vessels was noted in unstable atherosclerotic plaques. Macrophagic infiltration was detected in the intima of arteries, in places of accumulation of foam cells.
Conclusion. Unstable atherosclerotic plaque is a cellular-intercellular process with the participation of lipids, macrophages, and with predominance of SMC and newly formed vessels.
About the Author
S. S. Todorov
Rostov State Medical University
Russian Federation
Russian Federation
Todorov Sergey S. – MD
Rostov-on-DonReferences
1. World Health Organization. Global status report on non-communicable diseases 2010. http://www.who.int/nmh/publications/ncd_report_full_en.pdf
2. World Health Organization. Global atlas on cardiovascular disease prevention and control 2011. http://www.who.int/nmh/publications/ncd_profiles_report.pdf
3. Mathers C.D., Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PloS Medicine 2006;3(11):442. DOI: 10.1371/journal.pmed.0030442
4. Usman A., Ribbatti D., Sadat U., Gillard J.H. From lipid retention to immune-mediate inflammation and associated angiogenesis in the pathogenesis of atherosclerosis. Journal of Atheroscler Thromb 2015;22(8):739–749. DOI: 10.5551/jat.30460
5. Virmani R., Kolodgie F.D., Burke A.P. et al. Lessons from sudden coronary death: a comprehensive morphological classification sheme for atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology 2000;20(5):1262–1275. DOI: 10.1161/01.ATV.20.5.1262
6. Stoger J.L., Gijbels M.J., van der Velden S. et al. Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis 2012;225(2):461–468. DOI:10.1016/j.atherosclerosis.2012.09.013
7. Tesauro M., Mauriello A., Rovella V. et al. Arterial ageing: from endothelial dysfunction to vascular calcification. J Int Med 2017;281(5):471–482. DOI: 10.1111/joim.12605.
8. Tabas I., Bornfeldt K.E. Macrophage phenotype and function in different stages of atherosclerosis. Circ Res 2016;118(4):653– 667. DOI:10.1161/CIRCRESAHA.115/306256
9. Pathology. National guidebook. Moscow, 2011. Russian (Патологическая анатомия. Национальное руководство. М., 2011).
10. Marx S.O., Totary-Jain H., Marks A.R. Vascular smooth muscle cell proliferation in restenosis. Circulation: Cardiovasc Interv 2011;4(1):104–111. DOI: 10.116/CIRCINTERVENTIONS.110.967332
11. Tabas I., Williams K.J., Boren J. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 2007;116(16):1832–1844. DOI:10.1161/CIRCULATIONAHA.106.676890
12. Chinetti-Gbaguidi G., Colin S., Staels B. Macrophage subsets in atherosclerosis. Nature Reviews Cardiology 2015;12(1):10–17. DOI: 10.1038/nrcardio.2014.173
13. Gomez D., Owens G.K. Smooth muscle cell phenotypic switching in atheroscleosis. Cardiovasc Res 2012;95(2):156–164. DOI: 10.1093/cvr/cvs115
14. Allahverdian S., Chehroudi A.C., McManus B.M. et al. Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Circulation 2014;129(15):1551–1559. DOI: 10.1161/CIRCULATIONAHA.113.005015
15. Sukhovershin R.A., Toledano Furman N.E. et al. Local inhibition of macrophage and smooth muscle cell proliferation to suppress plaque progression. Methodist DeBakey Cardiovasc J 2016;12 (3):141–145. DOI: 10.14797/mdcj-12-3-141
16. Todorov S.S. Smooth muscle cells in cardiovascular pathology. Rossiisky kardiologicheskyi zhurnal 2009;5(79):91–94. Russian (Тодоров С.С. Гладкие миоциты в патологии сердечно-сосудистой системы. Российский кардиологический журнал 2009;5(79):91–94.)
17. Klimov A.N., Nikulcheva N.G. Exchange of lipids and lipoproteins and its violation. A Practical Guide. Moscow.1999. Russian (Климов А.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения. Практическое руководство. М., 1999).
18. Nagornev V.A. Pathogenesis of atherosclerosis. Moscow, 2006. 240p. Russian (Нагорнев В.А. Патогенез атеросклероза. М., 2006, 240 с).
Review
For citations:
Todorov S.S. The Role of Smooth Myocytes and Macrophages in Development of Complicated Forms of Arterial Atherosclerosis. Kardiologiia. 2019;59(1):57-61. (In Russ.) https://doi.org/10.18087/cardio.2019.1.10207
Views:
1461
Email this article 
Post a Comment 
