Generate QR code
Open Access
Subscription Access
Adherence to Treatment of Arterial Hypertension, the Place of Fixed-Dose Combinations
https://doi.org/10.18087/cardio.2025.5.n2925
Abstract
Cardiovascular diseases occupy one of the leading places in the structure of morbidity, mortality and disability of the population. Arterial hypertension (AH) is the major risk factor for the development of cardiovascular diseases. The problem of insufficient adherence to the treatment of AH remains unresolved in many countries. The administration of fixed combinations is a major way to increase adherence to antihypertensive therapy. In addition, the use of fixed combinations helps to improve the cardiovascular the prognosis in patients with AH by reducing the risk of developing cardiovascular complications.
Supporting agencies: No conflict of interest is reported.
About the Authors
E. V. Akatova
Russian University of Medicine
Russian Federation
Russian Federation
professor kafedry gospital'noy terapii №1, d.m.n
Moscow, Russia
M. A. Shikina
Russian University of Medicine
Russian Federation
Russian Federation
Resident of the Department of Hospital Therapy No. 1
Moscow, Russia
References
1. Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nature Reviews Nephrology. 2020;16(4):223–37. DOI: 10.1038/s41581-019-0244-2
2. Balanova Yu.A., Drapkina O.M., Kutsenko V.A., Imaeva A.E., Kontsevaya A.V., Maksimov S.A. et al. Hypertension in the Russian population during the COVID-19 pandemic: sex differences in prevalence, treatment and its effectiveness. Data from the ESSE-RF3 study. Cardiovascular Therapy and Prevention. 2023;22(S8):105–20. DOI: 10.15829/1728-8800-2023-3785
3. Pickersgill SJ, Msemburi WT, Cobb L, Ide N, Moran AE, Su Y et al. Modeling global 80-80-80 blood pressure targets and cardiovascular outcomes. Nature Medicine. 2022;28(8):1693–9. DOI: 10.1038/s41591-022-01890-4
4. Lopes S, Félix G, Mesquita-Bastos J, Figueiredo D, Oliveira J, Ribeiro F. Determinants of exercise adherence and maintenance among patients with hypertension: a narrative review. Reviews in Cardiovascular Medicine. 2021;22(4):1271–8. DOI: 10.31083/j.rcm2204134
5. World Health Organization. Adherence to long-term therapies: evidence for action. - Geneva: World Health Organization; 2003. - 198p. ISBN 978-92-4-154599-0
6. McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. European Heart Journal. 2024;45(38):3912–4018. DOI: 10.1093/eurheartj/ehae178
7. Nedogoda S.V., Sabanov A.V., Bychkova O.I. Barriers to effective outpatient hypertension treatment: a view of physicians and patients. Russian Journal of Cardiology. 2020;25(4):39–45. DOI: 10.15829/1560-4071-2020-3776
8. Burnier M, Egan BM. Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact and Management. Circulation Research. 2019;124(7):1124–40. DOI: 10.1161/CIRCRESAHA.118.313220
9. Laurent S, Boutouyrie P. Arterial Stiffness and Hypertension in the Elderly. Frontiers in Cardiovascular Medicine. 2020;7:544302. DOI: 10.3389/fcvm.2020.544302
10. Lee EKP, Poon P, Yip BHK, Bo Y, Zhu M, Yu C et al. Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A MetaAnalysis Involving 27 Million Patients. Journal of the American Heart Association. 2022;11(17):e026582. DOI: 10.1161/JAHA.122.026582
11. Thandar W, Samoraphop B, Ruaisungnoen W. Factors Influencing Medication Adherence among Patients with Hypertension: A Systematic Review. Systematic Reviews in Pharmacy. 12:526–38. DOI: 10.31838/srp.2021.1.76
12. Rotar O.P., Erina A.M., Boiarinova M.A., Moguchaia E.V., Kolesova E.P., Tolkunova K.M. et al. Hypertension control during the COVI D-19 pandemic: results of the MMM2021 in Russia. Russian Journal of Cardiology. 2022;27(4):7–13. DOI: 10.15829/1560-4071-2022-5014
13. Alefan Q, Huwari D, Alshogran O, Jarrah MI. Factors affecting hypertensive patients’ compliance with healthy lifestyle. Patient Preference and Adherence. 2019;13:577–85. DOI: 10.2147/PPA.S198446
14. Reddeman L, Bourgeois N, Angl EN, Heinrich M, Hillier L, Finn H et al. How should family physicians provide physical activity advice? Qualitative study to inform the design of an e-health intervention. Canadian Family Physician Medecin De Famille Canadien. 2019;65(9):e411–9. PMID: 31515329
15. Scheltens T, Beulens JW, Verschuren WMM, Boer JM, Hoes AW, Grobbee DE et al. Awareness of hypertension: will it bring about a healthy lifestyle? Journal of Human Hypertension. 2010;24(9):561–7. DOI: 10.1038/jhh.2010.26
16. Kim H, Andrade FCD. Diagnostic status of hypertension on the adherence to the Dietary Approaches to Stop Hypertension (DASH) diet. Preventive Medicine Reports. 2016;4:525–31. DOI: 10.1016/j. pmedr.2016.09.009
17. Kobalava Zh.D., Konradi A.O., Nedogoda S.V., Shlyakhto E.V., Arutyunov G.P., Baranova E.I. et al. 2024 Clinical practice guidelines for Hypertension in adults. Russian Journal of Cardiology. 2024;29(9):230–329. DOI: 10.15829/1560-4071-2024-6117
18. Rotar O.P., Ilyanova I.N., Boyarinova M.A., Moguchaya E.V., Tolkunova K.M., Dyachkov V.A. et al. 2023 All-Russian screening for hypertension: results. Russian Journal of Cardiology. 2024;29(5):78–88. DOI: 10.15829/1560-4071-2024-5931
19. Belenkov Yu.N., Glezer M.G., Kozhevnikova M.V., Chernichka K.S., Matveev N.V. Patient Adherence and Duration of Continuous Treatment With Various Arbs in Patients With Uncomplicated Arterial Hypertension in the USA Based on The Analysis of the Truven Health Analytics MarketScan Database. Kardiologiia. 2024;64(9):39–47. DOI: 10.18087/cardio.2024.9.n2689
20. Machilskaya O.V. The factors determining adherence to treatment in arterial hypertension patients (literature review). Cardiology and Cardiovascular Surgery. 2016;9(3):55–65. DOI: 10.17116/kardio20169355-65
21. Parati G, Kjeldsen S, Coca A, Cushman WC, Wang J. Adherence to Single-Pill Versus Free-Equivalent Combination Therapy in Hypertension: A Systematic Review and Meta-Analysis. Hypertension. 2021;77(2):692–705. DOI: 10.1161/HYPERTENSIONAHA.120.15781
22. Borghi C, Wang J, Rodionov AV, Rosas M, Sohn IS, Alcocer L et al. Projecting the long-term benefits of single pill combination therapy for patients with hypertension in five countries. International Journal of Cardiology Cardiovascular Risk and Prevention. 2021;10:200102. DOI: 10.1016/j.ijcrp.2021.200102
23. Snyman JR, Bortolotto LA, Degli Esposti L, Jayagopal PB, Konradi AO, Perrone V et al. A real-world analysis of outcomes and healthcare costs of patients on perindopril/indapamide/amlodipine single-pill vs. multiple-pill combination in Italy. Journal of Hypertension. 2024;42(1):136–42. DOI: 10.1097/HJH.0000000000003570
24. Rea F, Morabito G, Savaré L, Pathak A, Corrao G, Mancia G. Adherence and related cardiovascular outcomes to single pill vs. separate pill administration of antihypertensive triple-combination therapy. Journal of Hypertension. 2023;41(9):1466–73. DOI: 10.1097/HJH.0000000000003497
25. Weisser B, Wassmann S, Predel H-G, Schmieder RE, Gillessen A, Wilke T et al. Effect of a single pill concept on clinical and pharmacoeconomic outcomes in cardiovascular diseases. European Heart Journal - Cardiovascular Pharmacotherapy. 2025;10(8):686–93. DOI: 10.1093/ehjcvp/pvae059
26. Wilke T, Weisser B, Predel H-G, Schmieder RE, Wassmann S, Gillessen A et al. Effects of Single Pill Combinations Compared to Identical Multi Pill Therapy on Outcomes in Hypertension, Dyslipidemia and Secondary Cardiovascular Prevention: The START-Study. Integrated Blood Pressure Control. 2022;15:11–21. DOI: 10.2147/IBPC.S336324
Review
For citations:
Akatova E.V., Shikina M.A. Adherence to Treatment of Arterial Hypertension, the Place of Fixed-Dose Combinations. Kardiologiia. 2025;65(5):52-57. (In Russ.) https://doi.org/10.18087/cardio.2025.5.n2925
Views:
262
Email this article 
Post a Comment 
