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Pulmonary Embolism: Current Challenges and Future Directions
https://doi.org/10.18087/cardio.2025.7.n2885
Abstract
Pulmonary embolism (PE) is a complex emergency condition, the diagnosis and treatment of which still have many unresolved issues and "gray areas". Current clinical guidelines for the management of patients with PE are partly outdated and do not take into account a number of modern data. In this review, the authors identified unresolved issues and provided the latest data on the assessment of pre-test probability, risk stratification, diagnosis and treatment of acute PE, particularly in patients with intermediate-high and high risk of death. The issues of reperfusion catheter techniques and intensive care are addressed individually. The requirement for specialized PE centers of expert level and their prospects are discussed
Keywords
Pulmonary embolism,
PE,
catheter reperfusion,
systemic thrombolytic therapy,
pre-test probability,
risk stratification
Supporting agencies: No conflict of interest is reported.
About the Authors
I. A. Merkulova
Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Cardiologist of the Intensive Care Unit, Laboratory Researcher of the Emergency Cardiology Department
Moscow, Russia
N. S. Germanov
Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Resident of the Emergency Cardiology Department
Moscow, Russia
Z. B. Bashankaeva
Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Resident of the Emergency Cardiology Department
Moscow, Russia
I. S. Yavelov
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Doctor of Medical Sciences, Leading Researcher Department of Clinical Cardiology and Molecular Genetics
Moscow, Russia
D. V. Pevzner
Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Doctor of Medical Sciences, Head of the Intensive Care Unit of the Emergency Cardiology Department
Moscow, Russia
S. A. Boytsov
Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
General Director, Member of Russian Academy of Sciences, Doctor of Medical Science, Prof., Lead Clinician for Cardiology in Central, Ural, Siberian and Far-Eastern Federal Districts
Moscow, Russia
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Review
For citations:
Merkulova I.A., Germanov N.S., Bashankaeva Z.B., Yavelov I.S., Pevzner D.V., Boytsov S.A. Pulmonary Embolism: Current Challenges and Future Directions. Kardiologiia. 2025;65(7):74-82. (In Russ.) https://doi.org/10.18087/cardio.2025.7.n2885
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