The role of telocytes in myocardial remodeling and the development of cardiovascular complications in patients with chronic heart failure after coronary artery bypass grafting

Aim of the study. A study of the role of cardiac telocytes (Tc) in myocardial remodeling and the effect of changes in their morphology on the clinical outcome of coronary bypass (CABG) in patients with chronic heart failure (CHF). Materials and methods. The perioperative period was analyzed in 83 patients (43 men and 40 women) with CHF I, IIA and IIB, NYHA functional class I-III undergoing CABG. Myocardial biopsy of the right atrial appendage (RAA), obtained during the CABG, was studied using histological, immuno-histochemical (expression of CD-34/vimentin, MMP-2, TIMP-1, caspase-3, bcl-2) and morphometric methods. Results. In the analysis of the myocardium of RAA of a group of patients with cardiovascular complications (CVC) after CABG, a significant decrease in the diameter of cardiomyocytes (CMCs) of their nuclei, bulk density (BD) of CMC, a significant decrease in BD Tc, trophic index; an increase in CMC with signs of apoptosis, BD of stroma, a violation of the ratio of MMP-2/TIMP-1. Conclusions. The intercellular network Tc with secreted regulatory factors and microvesicles is an important structural and functional link of the myocardium. The decrease in BD Tc has a significant effect on the remodeling and regenerative potential of the myocardium, leading to the development of CVC in patients with CHF.

телоциты, ремоделирование миокарда, сердечная недостаточность, коронарное шунтирование, осложнения, telocytes, myocardial remodeling, heart failure, coronary bypass surgery, complications

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