Оценка взаимосвязи между дефицитом витамина D и субклинической сердечной дисфункцией по данным оценки деформационных свойств миокарда с помощью 2D/3D эхокардиографии у здоровых людей

Цель. Дефицит витамина D имеет высокую распространенность среди населения и тесно связан с сердечно-сосудистыми заболеваниями. Цель этого исследования состояла в том, чтобы оценить субклиническую дисфункцию левого желудочка (ЛЖ) с помощью анализа деформации у здоровых людей с дефицитом витамина D.

Материал и методы. В исследование были включены 113 здоровых добровольцев (возраст 44,1±7 лет, 34 мужчины). Всем добровольцам была проведена двухмерная (2D) и трехмерная (3D) эхокардиография (ЭхоКГ) с отслеживанием спекл-трекинга после стандартной эхокардиографической оценки. Субъекты были разделены на две группы в зависимости от содержания витамина D. 61 субъект с уровнем витамина D менее 20 нг/мл был включен в группу с дефицитом витамина D. Исходные клинические характеристики, лабораторные измерения, эхокардиографические данные, включая значения общей продольной деформации (GLS) в 2D и 3D, сравнивались между группами.

Результаты. Значения GLS по данным 2D ЭхоКГ у субъектов с дефицитом витамина D были ниже (математически менее отрицательными), чем у субъектов с нормальным уровнем витамина D (-16,1±3,4 против -19,3±4,2, p<0,001). Также значения GLS по данным 3D исследования были ниже у лиц с дефицитом витамина D (-18,3±5,2 против -24,1±6,9, p<0,001). Была обнаружена значительная корреляция между концентрацией витамина D и измерениями GLS по данным 2D и 3D ЭхоКГ (r=0,765 и r=0,628 соответственно, p<0,001). Было обнаружено, что витамин D является независимым предиктором нарушений GLS левого желудочка по данным 2D и 3D ЭхоКГ (p=0,031, p=0,023 соответственно).

Заключение. Субклиническая дисфункция ЛЖ у здоровых лиц с дефицитом витамина D была продемонстрирована с помощью 3D- и 2D-анализа деформации. Из-за потенциального негативного воздействия дефицита витамина D на сердечную функцию следует уделять больше внимания здоровым людям с дефицитом витамина D.

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