Ticagrelor Induced Cheyne-Stokes Respiration and Asystolic Ventricular Standstill: A Case Report
https://doi.org/10.18087/cardio.2024.2.n2123
Abstract
Ticagrelor is a potent, direct-acting, and reversible P2Y12‑adenosine diphosphate receptor blocker. It has a rapid onset of action and an intense and consistent platelet reactivity inhibition that has been demonstrated to be superior to clopidogrel in decreasing major adverse events in acute coronary syndrome (ACS). Although ticagrelor is well tolerated in ACS patients, it has side effects, such as dyspnea and bradyarrhythmia, as reported in the Platelet Inhibition and Patient Outcomes (PLATO) study. Furthermore, it was reported that ticagrelor’s bradyarrhythmic potential was transient and not clinically significant beyond the acute initiation phase. Nor was there a difference in rates of syncope or need for pacemaker insertion during 30 days of follow-up. Here we report a case of ticagrelor associated with Cheyne-Stokes respiration and asystolic ventricular standstill in a patient with ACS who required resuscitation and insertion of a temporary pacemaker.
About the Authors
Bektaş Murat
Eskisehir City Hospital
Turkey
Turkey
MD
Department of Cardiology,
Eskisehir
Selda Murat
Eskisehir Osmangazi University
Turkey
Turkey
Assist. Prof
Medical Faculty, Department of Cardiology,
Eskisehir
Eylem Kivanc
Eskisehir City Hospital
Turkey
Turkey
MD
Department of Cardiology,
Eskisehir
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Review
For citations:
Murat B., Murat S., Kivanc E. Ticagrelor Induced Cheyne-Stokes Respiration and Asystolic Ventricular Standstill: A Case Report. Kardiologiia. 2024;64(2):80-84. https://doi.org/10.18087/cardio.2024.2.n2123
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