ВАЖНО! Правила приравнивания журналов, входящих в международные базы данных к журналам перечня ВАК.
Ответ на официальный запрос в ВАК журнала Кардиология.

Preview

Кардиология

Расширенный поиск

Блокада левой ножки пучка Гиса – дилатационная кардиомиопатия – сердечная недостаточность: общие звенья замкнутой цепи патогенеза

https://doi.org/10.18087/cardio.2023.2.n1773

Аннотация

В обзоре обобщена доступная информация, посвященная эпидемиологии и прогнозу больных с блокадой левой ножки пучка Гиса (БЛНПГ), морфологическим изменениям миокарда, как приводящим к БЛНПГ, так и являющимся ее следствием, сердечной биомеханике при БЛНПГ, а также возможностям ее коррекции.

Об авторах

Е. М. Римская
ФГБУ «НМИЦ кардиологии имени академика Е. И. Чазова» Минздрава РФ
Россия

врач-кардиолог, старший научный сотрудник отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца Института клинической кардиологии ФГБУ «НМИЦ кардиологии» МЗ РФ

Москва, Россия

 



Н. А. Миронова
ФГБУ «НМИЦ кардиологии имени академика Е. И. Чазова» Минздрава РФ
Россия

врач-кардиолог, старший научный сотрудник отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца Института клинической кардиологии ФГБУ «НМИЦ кардиологии» МЗ РФ

Москва, Россия



С. Ф. Соколов
ФГБУ «НМИЦ кардиологии имени академика Е. И. Чазова» Минздрава РФ
Россия

врач-кардиолог, ведущий научный сотрудник отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца Института клинической кардиологии ФГБУ «НМИЦ кардиологии» МЗ РФ

Москва, Россия



С. П. Голицын
ФГБУ «НМИЦ кардиологии имени академика Е. И. Чазова» Минздрава РФ
Россия

руководитель отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца Института клинической кардиологии ФГБУ «НМИЦ кардиологии» МЗ РФ, профессор

Москва, Россия



Список литературы

1. Eppinger H, Rothberger CJ. Zur analyse des ekctrokardiogramms. Wien Klin Wochenschr. 1909;22:1091–8

2. Sipahi I, Carrigan TP, Rowland DY, Stambler BS, Fang JC. Impact of QRS duration on clinical event reduction with cardiac resynchronization therapy: meta-analysis of randomized controlled trials. Archives of Internal Medicine. 2011;171(16):1454–62. DOI: 10.1001/archinternmed.2011.247

3. Gervais R, Leclercq C, Shankar A, Jacobs S, Eiskjaer H, Johannessen A et al. Surface electrocardiogram to predict outcome in candidates for cardiac resynchronization therapy: a sub-analysis of the CARE-HF trial. European Journal of Heart Failure. 2009;11(7):699–705. DOI: 10.1093/eurjhf/hfp074

4. Vernooy K, Cornelussen RNM, Verbeek XAAM, Vanagt WYR, van Hunnik A, Kuiper M et al. Cardiac resynchronization therapy cures dyssynchronopathy in canine left bundle-branch block hearts. European Heart Journal. 2007;28(17):2148–55. DOI: 10.1093/eurheartj/ehm207

5. Sze E, Daubert JP. Left bundle branch block-induced left ventricular remodeling and its potential for reverse remodeling. Journal of Interventional Cardiac Electrophysiology. 2018;52(3):343–52. DOI: 10.1007/s10840-018-0407-2

6. Vaillant C, Martins RP, Donal E, Leclercq C, Thébault C, Behar N et al. Resolution of Left Bundle Branch Block–Induced Cardiomyopathy by Cardiac Resynchronization Therapy. Journal of the American College of Cardiology. 2013;61(10):1089–95. DOI: 10.1016/j.jacc.2012.10.053

7. Curtius JM, Stechern V, Kuhn H, Loogen F. Echocardiographic follow-up in latent cardiomyopathy. Zeitschrift Fur Kardiologie. 1984;73(11):695–700. PMID: 6523968

8. Baggish AL, Hutter AMJ, Wang F, Yared K, Weiner RB, Kupperman E et al. Cardiovascular Screening in College Athletes With and Without Electrocardiography: A Cross-sectional Study. Annals of Internal Medicine. 2010;152(5):269–75. DOI: 10.7326/0003-4819-152-5-201003020-00004

9. Pelliccia A, Maron BJ, Culasso F, Di Paolo FM, Spataro A, Biffi A et al. Clinical Significance of Abnormal Electrocardiographic Patterns in Trained Athletes. Circulation. 2000;102(3):278–84. DOI: 10.1161/01.CIR.102.3.278

10. Wilson MG, Chatard JC, Carre F, Hamilton B, Whyte GP, Sharma S et al. Prevalence of electrocardiographic abnormalities in WestAsian and African male athletes. British Journal of Sports Medicine. 2012;46(5):341–7. DOI: 10.1136/bjsm.2010.082743

11. Imanishi R, Seto S, Ichimaru S, Nakashima E, Yano K, Akahoshi M. Prognostic Significance of Incident Complete Left Bundle Branch Block Observed Over a 40-Year Period. The American Journal of Cardiology. 2006;98(5):644–8. DOI: 10.1016/j.amjcard.2006.03.044

12. Eriksson P, Hansson P-O, Eriksson H, Dellborg M. Bundle-Branch Block in a General Male Population: The Study of Men Born 1913. Circulation. 1998;98(22):2494–500. DOI: 10.1161/01.CIR.98.22.2494

13. Kumar V, Venkataraman R, Aljaroudi W, Osorio J, Heo J, Iskandrian AE et al. Implications of Left Bundle Branch Block in Patient Treatment. The American Journal of Cardiology. 2013;111(2):291–300. DOI: 10.1016/j.amjcard.2012.09.029

14. Kuhn H, Breithardt G, Knieriem HJ, Kohler E, Losse B, Seipel L et al. Prognosis and possible presymptomatic manifestations of congestive cardiomyopathy (COCM). Postgraduate Medical Journal. 1978;54(633):451–61. DOI: 10.1136/pgmj.54.633.451

15. Schneider JF, Thomas HE, Kreger BE, McNamara PM, Kannel WB. Newly Acquired Left Bundle-Branch Block: The Framingham Study. Annals of Internal Medicine. 1979;90(3):303–10. DOI: 10.7326/0003-4819-90-3-303

16. Blanc J, Fatemi M, Bertault V, Baraket F, Etienne Y. Evaluation of left bundle branch block as a reversible cause of non-ischaemic dilated cardiomyopathy with severe heart failure. A new concept of left ventricular dyssynchrony-induced cardiomyopathy. Europace. 2005;7(6):604–10. DOI: 10.1016/j.eupc.2005.06.005

17. Marchandise B, Piette F, Chalant CH, Kremer R. Conduction disorders in aortic valve diseases. Acta Cardiologica. 1975;30(2):111–28. PMID: 1079997

18. Wilensky RL, Yudelman P, Cohen AI, Fletcher RD, Atkinson J, Virmani R et al. Serial electrocardiographic changes in idiopathic dilated cardiomyopathy confirmed at necropsy. The American Journal of Cardiology. 1988;62(4):276–83. DOI: 10.1016/0002-9149(88)90225-1

19. Xiao HB, Roy C, Fujimoto S, Gibson DG. Natural history of abnormal conduction and its relation to prognosis in patients with dilated cardiomyopathy. International Journal of Cardiology. 1996;53(2):163–70. DOI: 10.1016/0167-5273(95)02502-2

20. Søndergaard MM, Riis J, Bodker KW, Hansen SM, Nielsen J, Graff C et al. Associations between left bundle branch block with different PR intervals, QRS durations, heart rates and the risk of heart failure: a register-based cohort study using ECG data from the primary care setting. Open Heart. 2021;8(1):e001425. DOI: 10.1136/openhrt-2020-001425

21. Grigioni F, Carinci V, Boriani G, Bracchetti G, Potena L, Magnani G et al. Accelerated QRS widening as an independent predictor of cardiac death or of the need for heart transplantation in patients with congestive heart failure. The Journal of Heart and Lung Transplantation. 2002;21(8):899–902. PMID: 12163090

22. Grines CL, Bashore TM, Boudoulas H, Olson S, Shafer P, Wooley CF. Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony. Circulation. 1989;79(4):845–53. DOI: 10.1161/01.CIR.79.4.845

23. Littmann L, Symanski JD. Hemodynamic implications of left bundle branch block. Journal of Electrocardiology. 2000;33(Suppl):115–21. DOI: 10.1054/jelc.2000.20330

24. Bourassa MG, Boiteau GM, Allenstein BJ. Hemodynamic studies during intermittent left bundle branch block. The American Journal of Cardiology. 1962;10(6):792–9. DOI: 10.1016/0002-9149(62)90173-X

25. Takeshita A, Basta LL, Kioschos JM. Effect of intermittent left bundle branch block on left ventricular performance. The American Journal of Medicine. 1974;56(2):251–5. DOI: 10.1016/0002-9343(74)90604-4

26. Grover M, Engler RL. Acute pulmonary edema induced by left bundle branch block. The American Journal of Cardiology. 1983;52(5):648–9. DOI: 10.1016/0002-9149(83)90048-6

27. Littmann L, Goldberg JR. Apparent bigeminy and pulsus alternans in intermittent left bundle-branch block. Clinical Cardiology. 1999;22(7):490–490. DOI: 10.1002/clc.4960220710

28. Sharma S, Barot HV, Schwartzman AD, Ganatra S, Shah SP, Venesy DM et al. Risk and predictors of dyssynchrony cardiomyopathy in left bundle branch block with preserved left ventricular ejection fraction. Clinical Cardiology. 2020;43(12):1494–500. DOI: 10.1002/clc.23467

29. Sze E, Dunning A, Loring Z, Atwater BD, Chiswell K, Daubert JP et al. Comparison of Incidence of Left Ventricular Systolic Dysfunction Among Patients With Left Bundle Branch Block Versus Those With Normal QRS Duration. The American Journal of Cardiology. 2017;120(11):1990–7. DOI: 10.1016/j.amjcard.2017.08.003

30. Strauss DG, Selvester RH, Wagner GS. Defining Left Bundle Branch Block in the Era of Cardiac Resynchronization Therapy. The American Journal of Cardiology. 2011;107(6):927–34. DOI: 10.1016/j.amjcard.2010.11.010

31. Auricchio A, Fantoni C, Regoli F, Carbucicchio C, Goette A, Geller C et al. Characterization of Left Ventricular Activation in Patients With Heart Failure and Left Bundle-Branch Block. Circulation. 2004;109(9):1133–9. DOI: 10.1161/01.CIR.0000118502.91105.F6

32. Zareba W, Klein H, Cygankiewicz I, Hall WJ, McNitt S, Brown M et al. Effectiveness of cardiac resynchronization therapy by QRS morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). Circulation. 2011;123(10):1061–72. DOI: 10.1161/CIRCULATIONAHA.110.960898

33. Gold MR, Thébault C, Linde C, Abraham WT, Gerritse B, Ghio S et al. Effect of QRS Duration and Morphology on Cardiac Resynchronization Therapy Outcomes in Mild Heart Failure: Results From the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) Study. Circulation. 2012;126(7):822–9. DOI: 10.1161/CIRCULATIONAHA.112.097709

34. Aranda JM, Conti JB, Johnson JW, Petersen-Stejskal S, Curtis AB. Cardiac resynchronization therapy in patients with heart failure and conduction abnormalities other than left bundle-branch block: analysis of the Multicenter InSync Randomized Clinical Evaluation (MIRACLE). Clinical Cardiology. 2004;27(12):678–82. DOI: 10.1002/clc.4960271204

35. Birnie DH, Ha A, Higginson L, Sidhu K, Green M, Philippon F et al. Impact of QRS morphology and duration on outcomes after cardiac resynchronization therapy: results from the Resynchronization-Defibrillation for Ambulatory Heart Failure Trial (RAFT). Circulation: Heart Failure. 2013;6(6):1190–8. DOI: 10.1161/CIRCHEARTFAILURE.113.000380

36. Кузнецов В.А., Малишевский Л.М., Тодосийчук В.В., Солдатова А.М. Оценка взаимосвязи различных критериев блокады левой ножки пучка Гиса с ответом на сердечную ресинхронизирующую терапию при хронической сердечной недостаточности. Кардиология. 2020;60(7):78–85. DOI: 10.18087/cardio.2020.7.n785

37. Каштанова С.Ю., Миронова Н.А., Гупало Е.М., Гаман С.А., Малкина Т.А., Тарасовский Г.С. и др. Оценка электрической диссинхронии миокарда с помощью неинвазивного активационного картирования и ее роль в достижении успеха проведения сердечной ресинхронизирующей терапии. Кардиология. 2019;59(4S):21-32. DOI: 10.18087/cardio.2613

38. Van Deursen CJM, Blaauw Y, Witjens MI, Debie L, Wecke L, Crijns HJGM et al. The value of the 12-lead ECG for evaluation and optimization of cardiac resynchronization therapy in daily clinical practice. Journal of Electrocardiology. 2014;47(2):202–11. DOI: 10.1016/j.jelectrocard.2014.01.007

39. Li Z, Dahlöf B, Okin PM, Kjeldsen SE, Wachtell K, Ibsen H et al. Left bundle branch block and cardiovascular morbidity and mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension study. Journal of Hypertension. 2008;26(6):1244–9. DOI: 10.1097/HJH.0b013e3282fcc23c

40. Aalen J, Storsten P, Remme EW, Sirnes PA, Gjesdal O, Larsen CK et al. Afterload Hypersensitivity in Patients With Left Bundle Branch Block. JACC: Cardiovascular Imaging. 2019;12(6):967–77. DOI: 10.1016/j.jcmg.2017.11.025

41. Lamas GA, Lee KL, Sweeney MO, Silverman R, Leon A, Yee R et al. Ventricular Pacing or Dual-Chamber Pacing for Sinus-Node Dysfunction. New England Journal of Medicine. 2002;346(24):1854–62. DOI: 10.1056/NEJMoa013040

42. Wilkoff BL, Cook JR, Epstein AE, Greene HL, Hallstrom AP, Hsia H et al. Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA. 2002;288(24):3115–23. PMID: 12495391

43. Barsheshet A, Moss AJ, McNitt S, Jons C, Glikson M, Klein HU et al. Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter-defibrillator. Heart Rhythm. 2011;8(2):212–8. DOI: 10.1016/j.hrthm.2010.10.035

44. Delgado V, Tops LF, Trines SA, Zeppenfeld K, Ajmone Marsan N, Bertini M et al. Acute Effects of Right Ventricular Apical Pacing on Left Ventricular Synchrony and Mechanics. Circulation: Arrhythmia and Electrophysiology. 2009;2(2):135–45. DOI: 10.1161/CIRCEP.108.814608

45. Prinzen FW, Peschar M. Relation Between the Pacing Induced Sequence of Activation and Left Ventricular Pump Function in Animals. Pacing and Clinical Electrophysiology. 2002;25(4):484–98. DOI: 10.1046/j.1460-9592.2002.00484.x

46. Liu W-H, Chen M-C, Chen Y-L, Guo B-F, Pan K-L, Yang C-H et al. Right Ventricular Apical Pacing Acutely Impairs Left Ventricular Function and Induces Mechanical Dyssynchrony in Patients with Sick Sinus Syndrome: A Real-time Three-dimensional Echocardiographic Study. Journal of the American Society of Echocardiography. 2008;21(3):224–9. DOI: 10.1016/j.echo.2007.08.045

47. Sweeney MO, Hellkamp AS, Ellenbogen KA, Greenspon AJ, Freedman RA, Lee KL et al. Adverse Effect of Ventricular Pacing on Heart Failure and Atrial Fibrillation Among Patients With Normal Baseline QRS Duration in a Clinical Trial of Pacemaker Therapy for Sinus Node Dysfunction. Circulation. 2003;107(23):2932–7. DOI: 10.1161/01.CIR.0000072769.17295.B1

48. Yu C-M, Fang F, Luo X-X, Zhang Q, Azlan H, Razali O. Long-term follow-up results of the Pacing to Avoid Cardiac Enlargement (PACE) trial. European Journal of Heart Failure. 2014;16(9):1016–25. DOI: 10.1002/ejhf.157

49. Curtis AB, Worley SJ, Adamson PB, Chung ES, Niazi I, Sherfesee L et al. Biventricular pacing for atrioventricular block and systolic dysfunction. New England Journal of Medicine. 2013;368(17):1585–93. DOI: 10.1056/NEJMoa1210356

50. Sweeney M, Hellkamp A, Greenspoon A. Baseline QRS duration ≥120 milliseconds and cumulative percent time ventricular paced predicts increased risk of heart failure, stroke, and death in DDDR-paced patients with sick sinus syndrome in MOST. Pacing and Clinical Electrophysiology. 2002;25(4 Pt 2):690

51. Roten L, Wenaweser P, Delacrétaz E, Hellige G, Stortecky S, Tanner H et al. Incidence and Predictors of Atrioventricular Conduction Impairment After Transcatheter Aortic Valve Implantation. The American Journal of Cardiology. 2010;106(10):1473–80. DOI: 10.1016/j.amjcard.2010.07.012

52. Nuis R-J, Van Mieghem NM, Schultz CJ, Tzikas A, Van der Boon RM, Maugenest A-M et al. Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis. European Heart Journal. 2011;32(16):2067–74. DOI: 10.1093/eurheartj/ehr110

53. Houthuizen P, Van Garsse LAFM, Poels TT, de Jaegere P, van der Boon RMA, Swinkels BM et al. Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. Circulation. 2012;126(6):720–8. DOI: 10.1161/CIRCULATIONAHA.112.101055

54. Martinez-Selles M, Bramlage P, Thoenes M, Schymik G. Clinical significance of conduction disturbances after aortic valve intervention: current evidence. Clinical Research in Cardiology. 2015;104(1):1–12. DOI: 10.1007/s00392-014-0739-6

55. Faroux L, Muntané-Carol G, Urena M, Nombela-Franco L, Amat-Santos I, Kleiman N et al. Late Electrocardiographic Changes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation. The American Journal of Cardiology. 2020;125(5):795–802. DOI: 10.1016/j.amjcard.2019.11.025

56. Upadhyay GA, Cherian T, Shatz DY, Beaser AD, Aziz Z, Ozcan C et al. Intracardiac Delineation of Septal Conduction in Left Bundle-Branch Block Patterns: Mechanistic Evidence of Left Intrahisian Block Circumvented by His Bundle Pacing. Circulation. 2019;139(16):1876–88. DOI: 10.1161/CIRCULATIONAHA.118.038648

57. Шляхто Е.В., Трешкур Т.В., Пармон Е.В., Гудкова А.Я., Овечкина М.А., Немков А.С. и др. Идиопатические желудочковые нарушения ритма: результаты проспективного наблюдении. Вестник аритмологии. 2004;33:5–11

58. Новикова Д.С., Бекбосынова М.С., Лоладзе Н.В., Антидзе Т.Я., Домогатский С.П., Голицын С.П. и др. С-реактивный белок и интерлейкин-6 у больных с желудочковыми нарушениями ритма сердца: возможная роль воспаления в развитии желудочковых аритмий. Кардиология. 2004;44(5):63–6

59. Грохотова В.В., Татарский Р.Б., Лебедев Д.С., Митрофанова Л.Б., Митрофанов Н.К., Пахомов А.В. и др. Диагностика некоронарогенных заболеваний у пациентов с желудочковыми тахикардиям. Вестник аритмологии. 2014;75:41-7

60. Гупало Е.М., Миронова Н.А., Рогова ММ., Чумаченко П.В., Ткачев Г.А., Наумова М.А. и др. Исследование клинико-инструментальных и морфологических показателей, а также экспрессии Коксаки-аденовирусного рецептора у больных воспалительными заболеваниями миокарда. Кардиология. 2014;54(5):8-15. DOI: 10.18565/cardio.2014.5.8-15

61. Angelini A, Crosato M, Boffa GM, Calabrese F, Calzolari V, Chioin R et al. Active versus borderline myocarditis: clinicopathological cor relates and prognostic implications. Heart. 2002;87(3):210–5. DOI: 10.1136/heart.87.3.210

62. Hegewisch S, Weh HJ, Hossfeld DK. TNF-induced cardiomyopathy. The Lancet. 1990;335(8684):294–5. DOI: 10.1016/0140-6736(90)90115-L

63. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide. Science. 1992;257(5068):387–9. DOI: 10.1126/science.1631560

64. Blum A, Miller H. Role of cytokines in heart failure. American Heart Journal. 1998;135(2):181–6. DOI: 10.1016/S0002-8703(98)70080-8

65. Mazzoleni A, Curtin ME, Wolff R, Reiner L, Somes G. On the relationship between heart weights, fibrosis, and QRS duration. Journal of Electrocardiology. 1975;8(3):233–6. DOI: 10.1016/S0022-0736(75)80050-1

66. Yamada T, Fukunami M, Ohmori M, Iwakura K, Kumagai K, Kondoh N et al. New approach to the estimation of the extent of myocardial fibrosis in patients with dilated cardiomyopathy: Use of signal-averaged electrocardiography. American Heart Journal. 1993;126(3):626–31. DOI: 10.1016/0002-8703(93)90413-4

67. Гупало Е.М., Стукалова О.В., Миронова Н.А., Нарусов О.Ю., Величко Л.В., Чумаченко П.В. и др. Возможности МРТ сердца в выявлении воспаления у больных с идиопатическими нарушениями проводимости сердца и у больных с клиническим синдромом дилатационной кардиомиопатии. Вестник Аритмологии. 2014;77:32-41

68. Lenegre J. Etiology and pathology of bilateral bundle branch block in relation to complete heart block. Progress in Cardiovascular Diseases. 1964;6(5):409–44. DOI: 10.1016/S0033-0620(64)80001-3

69. Lev M. The pathology of complete atrioventricular block. Progress in Cardiovascular Diseases. 1964;6(4):317–26. DOI: 10.1016/S0033-0620(64)80005-0

70. van Oosterhout MFM, Prinzen FW, Arts T, Schreuder JJ, Vanagt WYR, Cleutjens JPM et al. Asynchronous Electrical Activation Induces Asymmetrical Hypertrophy of the Left Ventricular Wall. Circulation. 1998;98(6):588–95. DOI: 10.1161/01.CIR.98.6.588

71. Van Middendorp LB, Kuiper M, Munts C, Wouters P, Maessen JG, van Nieuwenhoven FA et al. Local microRNA-133a downregulation is associated with hypertrophy in the dyssynchronous heart: miR-133a is associated with local hypertrophy. ESC Heart Failure. 2017;4(3):241–51. DOI: 10.1002/ehf2.12154

72. D’Ascia C, Cittadini A, Monti MG, Riccio G, Saccà L. Effects of biventricular pacing on interstitial remodelling, tumor necrosis factor-α expression, and apoptotic death in failing human myocardium. European Heart Journal. 2006;27(2):201–6. DOI: 10.1093/eurheartj/ehi579

73. Chakir K, Daya SK, Tunin RS, Helm RH, Byrne MJ, Dimaano VL et al. Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization. Circulation. 2008;117(11):1369–77. DOI: 10.1161/CIRCULATIONAHA.107.706291

74. Cvijic M, Duchenne J, Ünlü S, Michalski B, Aarones M, Winter S et al. Timing of myocardial shortening determines left ventricular regional myocardial work and regional remodelling in hearts with conduction delays. European Heart Journal - Cardiovascular Imaging. 2018;19(8):941–9. DOI: 10.1093/ehjci/jex325

75. Spragg D, Akar F, Helm R, Tunin R, Tomaselli G, Kass D. Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovascular Research. 2005;67(1):77–86. DOI: 10.1016/j.cardiores.2005.03.008

76. Josephson ME, Anter E. Substrate Mapping for Ventricular Tachycardia: assumptions and misconceptions. JACC: Clinical Electrophysiology. 2015;1(5):341–52. DOI: 10.1016/j.jacep.2015.09.001

77. Maguy A, Le Bouter S, Comtois P, Chartier D, Villeneuve L, Wakili R et al. Ion Channel Subunit Expression Changes in Cardiac Purkinje Fibers: A Potential Role in Conduction Abnormalities Associated With Congestive Heart Failure. Circulation Research. 2009;104(9):1113–22. DOI: 10.1161/CIRCRESAHA.108.191809

78. Ladenvall P, Andersson B, Dellborg M, Hansson P-O, Eriksson H, Thelle D et al. Genetic variation at the human connexin 43 locus but not at the connexin 40 locus is associated with left bundle branch block. Open Heart. 2015;2(1):e000187. DOI: 10.1136/openhrt-2014-000187

79. Fontes MSC, van Veen TAB, de Bakker JMT, van Rijen HVM. Functional consequences of abnormal Cx43 expression in the heart. Biochimica et Biophysica Acta. 2012;1818(8):2020–9. DOI: 10.1016/j.bbamem.2011.07.039

80. Osório J. Meta-analysis identifies variants in 22 loci associated with QRS duration. Nature Reviews Cardiology. 2011;8(2):63–63. DOI: 10.1038/nrcardio.2010.214

81. Marsman RFJ, Bezzina CR, Freiberg F, Verkerk AO, Adriaens ME, Podliesna S et al. Coxsackie and Adenovirus Receptor Is a Modifier of Cardiac Conduction and Arrhythmia Vulnerability in the Setting of Myocardial Ischemia. Journal of the American College of Cardiology. 2014;63(6):549–59. DOI: 10.1016/j.jacc.2013.10.062


Рецензия

Для цитирования:


Римская Е.М., Миронова Н.А., Соколов С.Ф., Голицын С.П. Блокада левой ножки пучка Гиса – дилатационная кардиомиопатия – сердечная недостаточность: общие звенья замкнутой цепи патогенеза. Кардиология. 2023;63(2):68-76. https://doi.org/10.18087/cardio.2023.2.n1773

For citation:


Rimskaya E.M., Mironova N.A., Sokolov S.F., Golitsyn S.P. Left bundle branch block – dilated cardiomyopathy – heart failure: common links in the closed pathogenetic chain. Kardiologiia. 2023;63(2):68-76. (In Russ.) https://doi.org/10.18087/cardio.2023.2.n1773

Просмотров: 2119


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 0022-9040 (Print)
ISSN 2412-5660 (Online)