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Evaluation of the Fractional Flow Reserve by Computer Tomography Data: Comparison of the Calculated Parameters with the Results of Invasive Measurements

https://doi.org/10.18087/cardio.2021.7.n1540

Abstract

Aim      To create a three-dimensional mathematical model of coronary flow in patients with ischemic heart disease based on findings of computed tomography angiography (CTA) with subsequent calculation of the fractional flow reserve (FFRCTA) and comparison of estimated FFRCTA with FFR reference values measured by coronary angiography (CAG).

Material and methods  The study included 10 patients with borderline stenosis (50–75 %) as determined by CTA performed with a 640‑slice CT-scanner. Based on CTA findings, three-dimensional mathematical models were constructed for further calculation of FFRCTA. Later, an invasive measurement of FFR (FFRINV) was performed for all patients. FFR values <0.8 indicated the hemodynamic significance of stenosis.

Results FFRCTA and FFRINV values differed insignificantly in most cases (n=9) and exceeded 5% in only one case. The regression analysis showed a close correlation between estimated and invasively measured FFR values.

Conclusion      Preliminary results showed a good consistency of calculated and measured FFR values. Therefore, further development of the method for mathematical modeling of three-dimensional blood flow by CTA findings is promising. Noninvasive evaluation of FFR is particularly relevant for analysis of hemodynamic significance of borderline (50–75 %) coronary stenoses.

 

 

About the Authors

T. N. Veselova
National medical research Center of cardiology of the Ministry of Healthcare of Russia, Moscow
Russian Federation

Tomograthy depertmant, Leading Researcher



S. K. Ternovoy
National medical research Center of cardiology of the Ministry of Healthcare of Russia, Moscow; Sechenov First Moscow State Medical University (Sechenov University), Moscow
Russian Federation
Tomography department, Chief Researcher of tjmjgraph department


A. M. Chepovskiy
Peoples Friendship University of Russia (RUDN University), Moscow
Russian Federation

professor of Department of Information technology





V. V. Borisenko
Lomonosov Moscow State University, Moscow
Russian Federation

Leading Researcher, PhD (Math.)



A. V. Gavrilov
Lomonosov Moscow State University, Moscow
Russian Federation

Head of the Laboratory of Medical Computer Systems

 



E. R. Blagosklonova
Gammamed-Soft, Ltd, Moscow
Russian Federation

research scientis



D. D. Dolotova
Gammamed-Soft, Ltd, Moscow
Russian Federation

Lead researcher, PhD (Med)

 



V. M. Mironov
National Medical Research Centre for Therapy and Preventive Medicine, Moscow
Russian Federation

Department of X-ray endovascular diagnostic and treatment methods, doctor for X-ray endovascular diagnosis and treatment, Ph.D



G. K. Arutyunyan
National Medical Research Centre for Therapy and Preventive Medicine, Moscow

junior researcher Department of X-ray Endovascular Diagnostic and Treatment Methods



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Review

For citations:


Veselova T.N., Ternovoy S.K., Chepovskiy A.M., Borisenko V.V., Gavrilov A.V., Blagosklonova E.R., Dolotova D.D., Mironov V.M., Arutyunyan G.K. Evaluation of the Fractional Flow Reserve by Computer Tomography Data: Comparison of the Calculated Parameters with the Results of Invasive Measurements. Kardiologiia. 2021;61(7):28-35. https://doi.org/10.18087/cardio.2021.7.n1540

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ISSN 0022-9040 (Print)
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