Efficacy and Safety of Combined Treament with Ivabradine and Metoprolol in Patients with Stable Angina Pectoris – a Systematic Review
https://doi.org/10.18087/cardio.2020.11.n1357
Abstract
This article presents results of a systematic review, which was designed for evaluating the effect of combination treatment with ivabradine and metoprolol on heart rate, frequency of angina attacks, frequency of using short-acting nitrates, and angina severity. The analysis included data from three large observational studies on efficacy of the ivabradine and metoprolol tartrate combination in patients with chronic angina. Results of the analysis supported the efficacy of the metoprolol and ivabradine combination in clinical practice, which provided effective decreases in the heart rate, frequency of angina attacks, requirement for short-acting nitrates, and alleviation of angina severity. The studies demonstrated good tolerability of this treatment.
Supporting agencies: Servier company
About the Authors
s. R. Gilarevskii
Russian medical academy of lifelong professional education, Moscow
Russian Federation
d.m.s., Professor of the department of clinical pharmacology and therapy
Russian Federation
d.m.s., Professor of the department of clinical pharmacology and therapy
E. V. Lantsova
LLC "Saynfaylz", Moscow
Russian Federation
doctor
Russian Federation
doctor
A. A. Akimov
LLC "Saynfaylz", Moscow
Russian Federation
doctor
Russian Federation
doctor
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Review
For citations:
Gilarevskii s.R., Lantsova E.V., Akimov A.A. Efficacy and Safety of Combined Treament with Ivabradine and Metoprolol in Patients with Stable Angina Pectoris – a Systematic Review. Kardiologiia. 2020;60(11):101–109. (In Russ.) https://doi.org/10.18087/cardio.2020.11.n1357
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