Deficit of Magnesium and States of Hypercoagulation: Intellectual Analysis of Data Obtained From a Sample of Patients Aged 18-50 years From Medical and Preventive Facilities in Russia

The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients. Aim: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia. Methods. The analysis was realized as analysis of data obtained in a cross-sectional study. In the cohort of patients (n=1453) formed from the IMBD adequacy of Mg supply was assessed by magnesium levels in blood plasma (Mg_BP) (0.69±0.15 mmol/L) and estimates of daily Mg consumption according to dietary diaries (Mg_D) (185±90 mg/day). Results. Mg supply was adequate (Mg_BP >0.80 mmol/L, Mg_D >300 mg/day) in not more than 6% of patients. Presence of “Hypercoagulation” label in data base was associated with greater number of chronic diseases (2.3±2.1 and 0.83±0.8 with and without this label, respectively, р=0.0006) and elevated risk of the presence on 4 comorbid pathologies (odds ratio [OR] 18, 95% confidence interval [CI] 10-25, р=0.0006). Mg deficit (Mg_BP <0.70 mmol/L) was associated with hypercoagulable states (OR 5.42, 95% CI 1.83-16, р=0.0006), neurologic pathologies (partial epilepsy, vertigo, alcohol dependence syndrome, obsessive - compulsive disorder) and pathologies related to chronic inflammation (ulcerative colitis, allergy, ischemic heart disease). Blood hypercoagulation was associated with prescription of drugs capable to provoke hypercoagulable states and simultaneously Mg deficit: androgens and anabolic steroids (OR 4.00, 95% CI 1.88-8.50, p=0.00008), immunodepressants (OR 5.16, 95%CI 1.96-13.58, р=0.0002), tetracyclic antidepressants (OR 4.47, 95%CI 1.54-13, р=0.0026), estrogen containing oral contraceptives (OR 3.3, 95%CI 1.5-6.2, р=0.0028), and antibiotics (OR 1.80, 95%CI 1-3.36, р=0.058). Lowered Mg_BP levels were associated with augmented sensation of pain, lowering of efficacy of analgesia, and with more pronounced cutaneous lesions. Conclusion. Thus, regular intake of magnesium preparations is indicated for the vast majority of adult patients in medico-preventive facilities especially to those with hypercoagulation and polypragmasy.

уровни магния в плазме крови, пищевое потребление магния, поперечные («кросс-секционные») исследования, интеллектуальный анализ данных, взрослые, magnesium plasma levels, dietary magnesium consumption, cross-sectional study, intellectual analysis

1. Torshin I. Yu., Tetruashvili N. K., Gromova O. A. Magnesium, pyridoxine and thrombophilia of pregnant women: molecular mechanisms and evidential medicine. Russian Bulletin of Obstetrician-Gynecologist 2010;10 (4):67-71. Russian (Торшин И. Ю., Тетруашвили Н. К., Громова О. А. Магний, пиридоксин и тромбофилия беременных: молекулярные механизмы и доказательная медицина. Российский вестник акушера-гинеколога 2010;10 (4):67-71).

2. Shechter M. The role of magnesium as antithrombotic therapy. Wien Med Wochenschr 2000;150 (15-16):343-347.

3. Ravn H. B., Vissinger H., Kristensen S. D., Husted S. E. Magnesium inhibits platelet activity - an in vitro study. Thromb Haemost 1996;76 (1):88-93.

4. Toft G., Ravn H. B., Hjortdal V. E. Intravenously and topically applied magnesium in the prevention of arterial thrombosis. Thromb Res 2000;99 (1):61-69.

5. Ravn H. B., Vissinger H., Kristensen S. D., et al. Magnesium inhibits platelet activity--an infusion study in healthy volunteers. Thromb Haemost 1996;75 (6):939-944.

6. Nigam S., Averdunk R., Gunther T. Alteration of prostanoid metabolism in rats with magnesium deficiency. Prostaglandins Leukot Med 1986;23 (1):1-10.

7. Zhou Q Zhou Y., Liu W., Kummerow F. A. Low magnesium stimulated prostacyclin generation in cultured human endothelial cells. Magnes Res 2008;21 (3):177-184.

8. Gromova O. A., Kalacheva A. G., Torshin I. Yu. et al. Magnesium deficiency as a risk factor of comorbid states: results of large-scale screening of the magnesian status in regions of Russia. Pharmateka 2013;6 (259):116-129. Russian (Громова О. А., Калачева А. Г., Торшин И. Ю. и др. Недостаточность магния - достоверный фактор риска коморбидных состояний: результаты крупномасштабного скрининга магниевого статуса в регионах России. Фарматека 2013;6 (259):116-129).

9. Gromova O. A., Limanova O. A., Gogoleva I. V. et al. Analysis of interrelation between security with a magnesium and risk of somatopathies at Russians of 18-45 years by methods of data mining. Effective pharmacotherapy 2014;23:10-23. Russian (Громова О. А., Лиманова О. А., Гоголева И. В. и др. Анализ взаимосвязи между обеспеченностью магнием и риском соматических заболеваний у россиянок 18-45 лет методами интеллектуального анализа данных. Эффективная фармакотерапия 2014;23:10-23).

10. Torshin I. Y., Rudakov K. V. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 1: Factorization approach. Pattern Recognit Image Anal 2017;27: 16. doi:10.1134/S10546618170 10151.

11. Torshin I. Y., Rudakov K. V. On metric spaces arising during formalization of problems of recognition and classification. Part 2: density properties. Pattern Recogn Image Anal 2016;26:483. doi:10.1134/ S1054661816030202.

12. Kerimkulova N. V., Nikiforova N. V., Vladimirova I. S. et al. Influence of an undifferentiated dysplasia of a connecting tissue on the result of pregnancy and labors. Comprehensive examination of pregnant women with a dysplasia of a connecting tissue with use of methods of data mining. Family Doctor 2013;2 (19):34-38. Russian (Керимкулова Н. В., Никифорова Н. В., Владимирова И. С. и др. Влияние недифференцированной дисплазии соединительной ткани на исходы беременности и родов. Комплексное обследование беременных с дисплазией соединительной ткани с использованием методов интеллектуального анализа данных. Земский врач 2013;2 (19):34-38).

13. Gromova O. A., Torshin I. Yu., Tomilova I. K. et al. Potassium, magnesium and pyridoxine in the context of biological effects of estrogens. Gynecology 2017; 19 (3):30-39. Russian (Громова О. А., Торшин И. Ю., Томилова И. К. и др. Калий, магний и пиридоксин в контексте биологических эффектов эстрогенов. Гинекология 2017;19 (3):30-39).

14. Gromova O. A., Torshin I. Yu., Moiseyev V. S., Sorokina M. A. On pharmacological interactions of a magnesium with antibiotics and the deficiency of a magnesium resulting from an antibioticotherapia. Therapy 2017;1:135-143. Russian (Громова О. А., Торшин И. Ю., Моисеев В. С., Сорокина М. А. О фармакологических взаимодействиях магния с антибиотиками и дефиците магния, возникающем в результате антибиотикотерапии. Терапия 2017;1:135-143).

15. Gromova O. A., Torshin I. Yu. Magnesium and “illnesses of a civilization" Moscow: GEOTAR media 2018;800p. Russian (Громова О. А., Торшин И. Ю. Магний и «болезни цивилизации». Москва: ГЭОТАР Медиа 2018;800с.).

16. Kopitsyna U. E., Grishina T. К., Torshin I. Yu. et al. Ultralow level of a magnesium in erythrocytes as a significant factor of a pathogenesis of boundary alienations. S. S. Korsakov Journal of Neurology and Psychiatry 2015;115 (11-1):85-96. Russian (Копицына У. Е., Гришина Т. Р., Торшин И. Ю. и др. Сверхнизкий уровень магния в эритроцитах как значимый фактор патогенеза пограничных психических расстройств. Журнал неврологии и психиатрии им. C. C. Корсакова 2015;115 (11-1):85-96).

17. Standards of physiological needs for energy and feedstuff's for various groups of the population of the Russian Federation. Methodical references. MP 2.3.1.2432-08.3.2.1. Russian (Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации. Методические рекомендации. МР 2.3.1.2432-08.3.2.1.).

18. Torshin I. Yu., Gromova O. A., Kalacheva A. G. et al. Metaanalysis of clinical influences of the orotat of a magnesium for cardiovascular system. Therapeutic archive 2015;87 (6):88-97. Russian (Торшин И. Ю., Громова О. А., Калачева А. Г. и др. Мета-анализ клинических воздействий оротата магния на сердечно-сосудистую систему. Терапевтический архив 2015;87 (6):88-97)