The role of selenium in cardiology
https://doi.org/10.18087/cardio.2021.3.n1186
Abstract
Selenium is an important micronutrient that is essential for the functioning of the human body. Being a component of the active center of several antioxidant enzymes selenium prevents cell injury by free radicals. Decline in selenium-containing enzymes results in progression of oxidative stress and chronic inflammation, which are considered as possible causes for the development of many cardiovascular diseases. This review focuses on mechanisms for prevention of myocardial and vascular injury through the adequate selenium supply to the body. The importance of monitoring and correction of the selenium status in appropriate patients is underlined.
Keywords
Selenium,
micronutrients,
oxidative stress,
antioxidants,
glutathione peroxidase,
cardiovascular diseases,
selenoproteins
Supporting agencies: No conflict of interest is reported.
About the Authors
T. A. Kuropatkina
Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, Russia
Russian Federation
Russian Federation
Faculty of Basic Medcine, Department of Pharmacology, postgraduate student
N. A. Medvedeva
Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
Russian Federation
Russian Federation
Biological faculty, Human and animal physiology department, professor
O. S. Medvedev
Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, Russia
National medical research Center of cardiology of the Ministry of healthcare, Moscow, Russia
Russian Federation
Russian Federation
1.Head of the Department of Pharmacology, Faculty of basic Medicine, professor
2.Head of Laboratory of Experimental Pharmacology
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Review
For citations:
Kuropatkina T.A., Medvedeva N.A., Medvedev O.S. The role of selenium in cardiology. Kardiologiia. 2021;61(3):96-104. (In Russ.) https://doi.org/10.18087/cardio.2021.3.n1186
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