cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2020.2.n985cardio-985Research ArticleОБЗОРЫREVIEWSПатогенетические механизмы развития патологии миокарда у больных со злокачественными новообразованиями: современное состояние проблемыPathogenetic mechanisms of development of myocardial pathology in patients with malignant tumors: the current state of the problemОбрезанА. Г.ObrezanA. G.

Санкт-Петербург

St. Petersburg

obrezan1@yandex.ruЩербаковаН. В.ShcherbakovaN. V.

Щербакова Наталья Владимировна

St. Petersburg

dr-lnv@yandex.ruГОУ ВПО «Санкт-Петербургский государственный университет»; Международный медицинский центр «СОГАЗ»РоссияSt. Petersburg State University, SOGAZ International Medical Center, St. PetersburgRussian FederationГОУ ВПО «Санкт-Петербургский государственный университет»РоссияSOGAZ International Medical Center, St. PetersburgRussian Federation202020012020602142154Copyright © Kardiomag, 20202020KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/985

Миокард, обладающий высокой метаболической активностью, реагирует на нарушения обмена веществ и энергетический дисбаланс под действием растущего злокачественного новообразования. Кроме того, сама опухоль способна продуцировать вещества, оказывающие непосредственное влияние на обменные процессы и жизненный цикл не затронутых опухолевым процессом клеток, в том числе кардиомиоцитов. В обзоре резюмированы и систематизированы имеющиеся на сегодняшний день данные исследований, посвященных отдельным аспектам повреждающего действия онкогенов и факторов, связанных с опухолевым процессом, на сердечную мышцу, морфофункциональным изменениям со стороны сердечно-сосудистой системы онкологических пациентов, подробно описаны патогенетические механизмы их развития.

The myocardium, which has a high metabolic activity, responds to metabolic disorders and energy imbalance induced by a growing malignant tumor. In addition, the tumor itself can produce substances that directly affect metabolic processes and the life cycle of cells not involved in the neoplastic process, including cardiomyocytes. This review summarized and systematized current data on individual aspects of detrimental effects of oncogenes and tumor-related factors on the heart muscle and morpho-functional changes in the cardiovascular system of oncology patients. Also, the authors described in detail development of these pathogenetic mechanisms.

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The authors declare that there are no conflicts of interest present.