cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2423cardio-89Research ArticleОБЗОРЫREVIEWSОсновные предикторы тромбоза стента у пациентов с острым коронарным синдромом после чрескожного коронарного вмешательства на фоне различной двойной антитромбоцитарной терапииMajor predictors of stent thrombosis in patients with acute coronary syndrome following transcutaneous coronary intervention who received different double antiplatelet therapyКоротаеваЕ. С.KorotaevaE. S.noemail@neicon.ruКоролеваЛ. Ю.KorolevaL. Yu.noemail@neicon.ruКовалеваГ. В.KovalevaG. V.noemail@neicon.ruКузьменкоЕ. А.KuzmenkoE. A.noemail@neicon.ruНосовВ. П.NosovV. P.noemail@neicon.ruФГБОУ ВО «НижГМА» МЗ РФРоссияNizhny Novgorod State Medical Academy, Minin and PozharskyRussian FederationГБУЗ НО «НОКБ им. Н. А. Семашко»РоссияNizhny Novgorod Regional Clinical Hospital named after N. A. SemashkoRussian Federation201818112018581S1221Copyright © Kardiomag, 20182018KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/89

В обзоре анализируются литературные источники, с разных сторон освещающие проблемы тромбоза стента, его основные предикторы, у пациентов с острым коронарным синдромом после чрескожного коронарного вмешательства. Освещаются вопросы сравнительной эффективности и безопасности тикагрелора и клопидогрела, а также влияния двойной антитромбоцитарной терапии на тромбоз стента. Затрагивается проблема приверженности пациентов к двойной антитромбоцитарной терапии. Необходимость такой комплексной оценки обусловлена тем, что несмотря на все усилия, включающие расширение как технических, так и терапевтических возможностей, проблема тромбоза стента остается актуальной.

The review analyzes the reports addressing from different standpoints the issue of stent thrombosis and its major predictors in patients with acute coronary syndrome following transcutaneous coronary interventions. The review focuses on comparative efficacy and safety of ticagrelor and clopidogrel and the effect of double antiplatelet therapy on stent thrombosis. The issue of patients’ compliance with double antiplatelet therapy is also discussed. Such comprehensive evaluation is warranted since despite all efforts for expanding both technical and therapeutic possibilities, the issue of stent thrombosis remains relevant.

острый коронарный синдромтромбоз стентадвойная антитромбоцитарная терапиятикагрелорклопидогрелприверженностьacute coronary syndromestent thrombosisdouble antiplatelet therapyticagrelorclopidogreladherenceReferencesJaffe R, Strauss BH. Late and very late thrombosis of drug-eluting stents: evolving concepts and perspectives. J Am Coll Cardiol. 2007;50(2):119 27. D01:10.1016/j. jacc. 2007.04.031Jaffe R, Strauss BH. Late and very late thrombosis of drug-eluting stents: evolving concepts and perspectives. J Am Coll Cardiol. 2007;50(2):119 27. D01:10.1016/j. jacc. 2007.04.031Moreno R, Fernandez C, Hernandez R, Alfonso F, Angiolillo DJ, Sabate M et al. Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies. J Am Coll Cardiol. 2005;45(6):954-9. D0I:10.1016/j. jacc. 2004.11.065Moreno R, Fernandez C, Hernandez R, Alfonso F, Angiolillo DJ, Sabate M et al. Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies. J Am Coll Cardiol. 2005;45(6):954-9. D0I:10.1016/j. jacc. 2004.11.065Riegger J, Byrne RA., Joner M, Chandraratne S, Gershlick AH, Ten Berg JM et al. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium. Eur Heart J. 2016;37(19):1538-49. DOI:10.1093/eurheartj/ehv419Riegger J, Byrne RA., Joner M, Chandraratne S, Gershlick AH, Ten Berg JM et al. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium. Eur Heart J. 2016;37(19):1538-49. DOI:10.1093/eurheartj/ehv419Urban P, Gershlick A H, Guagliumi G, Guyon P, Lotan C, Schofer J et al. Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher regist / ry. Circulation. 2006; 113(11): 1434-41. DOI:10.1161/CIRCULATI0NAHA.104. 532242Urban P, Gershlick A H, Guagliumi G, Guyon P, Lotan C, Schofer J et al. Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher regist / ry. Circulation. 2006; 113(11): 1434-41. DOI:10.1161/CIRCULATI0NAHA.104. 532242Roy P, Torguson R, 0kabe T, Pinto Slottow TL, Steinberg DH, Smith K et al. Comparison between sirolimus- and paclitaxel-eluting stents in complex patient and lesions subsets. Catheter Cardiovasc Interv. 2007;70 (2):167-72. DOI:10.1002/ccd. 21122Roy P, Torguson R, 0kabe T, Pinto Slottow TL, Steinberg DH, Smith K et al. Comparison between sirolimus- and paclitaxel-eluting stents in complex patient and lesions subsets. Catheter Cardiovasc Interv. 2007;70 (2):167-72. DOI:10.1002/ccd. 21122Tada T, Byrne RA., Simunovic I, King LA, Cassese S, Joner M et al. Risk of stent thrombosis among bare-metal stents, first-generation drug-eluting stents, and second-generation drug-eluting stents: results from a registry of 18,334 patients. JACC Cardiovasc Interv. 2013;6 (12):1267-74. DOI:10.1016/j. jcin. 2013.06.015Tada T, Byrne RA., Simunovic I, King LA, Cassese S, Joner M et al. Risk of stent thrombosis among bare-metal stents, first-generation drug-eluting stents, and second-generation drug-eluting stents: results from a registry of 18,334 patients. JACC Cardiovasc Interv. 2013;6 (12):1267-74. DOI:10.1016/j. jcin. 2013.06.015Räber L, Magro M, Stefanini GG, Kalesan B, van Domburg RT, 0numa Y et al. Very late coronary stent thrombosis of a newer-generation everolimus-eluting stent compared with early-generation drug-eluting stents: a prospective cohort study. Circulation. 2012;125(9):1110-21. DOI:10.1161/CIRCULATI0NAHA.111.058560Räber L, Magro M, Stefanini GG, Kalesan B, van Domburg RT, 0numa Y et al. Very late coronary stent thrombosis of a newer-generation everolimus-eluting stent compared with early-generation drug-eluting stents: a prospective cohort study. Circulation. 2012;125(9):1110-21. DOI:10.1161/CIRCULATI0NAHA.111.058560Абрамов А. С., Сальников Д. В., Никеров К. Ю. Тромбозы стентов у пациентов с острым ИМ. Кремлевская медицина Клинический вестник. 2011;(2):17-9. [Abramov A.S., Salnikov D.V, Nikerov K.Yu. Stent thrombosis in patients with acute myocardial infarction. Kremlin medicine. Clinical bulletin. 2011;2:17-9.]Абрамов А. С., Сальников Д. В., Никеров К. Ю. Тромбозы стентов у пациентов с острым ИМ. Кремлевская медицина Клинический вестник. 2011;(2):17-9. [Abramov A.S., Salnikov D.V, Nikerov K.Yu. Stent thrombosis in patients with acute myocardial infarction. Kremlin medicine. Clinical bulletin. 2011;2:17-9.]MonassierJP, Hamon M, Elias J, Maillard L, Spaulding C, Raynaud P et al. Early versus late coronary stenting following acute myocardial infarction: results of the STENTIM I Study (French Registry of Stenting in Acute Myocardial Infarction). Cathet Cardiovasc Diagn. 1997;42(3):243-8. PMID:9367093MonassierJP, Hamon M, Elias J, Maillard L, Spaulding C, Raynaud P et al. Early versus late coronary stenting following acute myocardial infarction: results of the STENTIM I Study (French Registry of Stenting in Acute Myocardial Infarction). Cathet Cardiovasc Diagn. 1997;42(3):243-8. PMID:9367093Aoki J, Lansky AJ, Mehran R, Moses J, Bertrand ME, McLaurin BT et al. Early stent thrombosis in patients with acute coronary syndromes treated with drug-eluting and bare metal stents: the Acute Catheterization and Urgent Intervention Triage Strategy trial. Circulation. 2009;119(5):687-98.D0I:10.1161/CIRCULATI0NAHA. 108.804203Aoki J, Lansky AJ, Mehran R, Moses J, Bertrand ME, McLaurin BT et al. Early stent thrombosis in patients with acute coronary syndromes treated with drug-eluting and bare metal stents: the Acute Catheterization and Urgent Intervention Triage Strategy trial. Circulation. 2009;119(5):687-98.D0I:10.1161/CIRCULATI0NAHA. 108.804203Patrono C, Garcia Rodriguez LA. A, Landolfi R, Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med. 2005;353(22):2373-83. DOI:10.1056/NEJMra052717Patrono C, Garcia Rodriguez LA. A, Landolfi R, Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med. 2005;353(22):2373-83. DOI:10.1056/NEJMra052717Windecker S, Meier B. Late coronary stent thrombosis. Circulation. 2007; 116 (17):1952-65. D0I:10.1161/CIRCULATI0NAHA. 106. 683995Windecker S, Meier B. Late coronary stent thrombosis. Circulation. 2007; 116 (17):1952-65. D0I:10.1161/CIRCULATI0NAHA. 106. 683995Иоселиани Д. Г., Роган С. В., Семитко С. П. Стентирование инфаркт-ответственной артерии в первые часы острого ИМ: ближайшие и среднеотдаленные результаты. Международный журнал интервенционной кардиоангиологии. 2003;(2):24-9. [Iosseliani D. G., Rogan S. V., Semitko S. P. Stentirovanie infarktotvetstvennoj arterii v pervye chasy ostrogo infarkta miokarda: blizhajshie i sredneotdalennye rezul'taty. International Journal of Interventional Cardioangiology. 2003;2:24-9. [In Russ.]]Иоселиани Д. Г., Роган С. В., Семитко С. П. Стентирование инфаркт-ответственной артерии в первые часы острого ИМ: ближайшие и среднеотдаленные результаты. Международный журнал интервенционной кардиоангиологии. 2003;(2):24-9. [Iosseliani D. G., Rogan S. V., Semitko S. P. Stentirovanie infarktotvetstvennoj arterii v pervye chasy ostrogo infarkta miokarda: blizhajshie i sredneotdalennye rezul'taty. International Journal of Interventional Cardioangiology. 2003;2:24-9. [In Russ.]]Буза В. В., Карпов Ю. А., Самко А. Н., Деев А. Д., Лопухова В. В., Левицкий И. В. и др. Оценка течения ИБС после установки стентов с лекарственным покрытием и непокрытых металлических стентов: данные трехлетнего наблюдения. Кардиология. 2009;49(1):9-13. [Buza V. V., Karpov Yu. A., Samko A. N., Deev A. D., Lopukhova V. V., Levitsky I. V., Sozykin A. V. Assessment of the Course of Ischemic Heart Disease After Placement of Stents With Drug Covering and Uncovered Metal Stents: Data of 3 Years Follow-up. Kardiologiia. 2009;49 (1):9-13.]Буза В. В., Карпов Ю. А., Самко А. Н., Деев А. Д., Лопухова В. В., Левицкий И. В. и др. Оценка течения ИБС после установки стентов с лекарственным покрытием и непокрытых металлических стентов: данные трехлетнего наблюдения. Кардиология. 2009;49(1):9-13. [Buza V. V., Karpov Yu. A., Samko A. N., Deev A. D., Lopukhova V. V., Levitsky I. V., Sozykin A. V. Assessment of the Course of Ischemic Heart Disease After Placement of Stents With Drug Covering and Uncovered Metal Stents: Data of 3 Years Follow-up. Kardiologiia. 2009;49 (1):9-13.]Iakovou I, Schmidt T, Bonizzoni E, Ge L, Sangiorgi GM, Stankovic G et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA. 2005;293(17):2126-30. DOI:10.1001/jama. 293.17.2126Iakovou I, Schmidt T, Bonizzoni E, Ge L, Sangiorgi GM, Stankovic G et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA. 2005;293(17):2126-30. DOI:10.1001/jama. 293.17.2126Lüscher TF, Steffel J, Eberli FR, Joner M, Nakazawa G, Tanner FC et al. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation. 2007;115(8):1051-8. DO1:10.1161 /CIRCULATIONAHA. 106.675934Lüscher TF, Steffel J, Eberli FR, Joner M, Nakazawa G, Tanner FC et al. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation. 2007;115(8):1051-8. DO1:10.1161 /CIRCULATIONAHA. 106.675934Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es G-A et al. Clinical end points in coronary stent trials: a case for standar-dized definitions. Circulation. 2007;115(17):2344-51. D0I:10.1161/ CIRCULATI0NAHA. 106.685313Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es G-A et al. Clinical end points in coronary stent trials: a case for standar-dized definitions. Circulation. 2007;115(17):2344-51. D0I:10.1161/ CIRCULATI0NAHA. 106.685313Schulz S, Schuster T, Mehilli J, Byrne RA., Ellert J, Massberg S et al. Stent thrombosis after drug-eluting stent implantation: incidence, timing, and relation to discontinuation of clopidogrel therapy over a 4-year period. Eur Heart J. 2009;30 (22):2714-21. D0I:10.1093/eurheartj/ehp275Schulz S, Schuster T, Mehilli J, Byrne RA., Ellert J, Massberg S et al. Stent thrombosis after drug-eluting stent implantation: incidence, timing, and relation to discontinuation of clopidogrel therapy over a 4-year period. Eur Heart J. 2009;30 (22):2714-21. D0I:10.1093/eurheartj/ehp275Farb A, Kolodgie FD, Hwang J-Y, Burke AP, Tefera K, Weber DK et al. Extracellular matrix changes in stented human coronary arteries. Circulation. 2004;110(8):940-7. D0I:10.1161/01. CIR. 0000139337.56084.30Farb A, Kolodgie FD, Hwang J-Y, Burke AP, Tefera K, Weber DK et al. Extracellular matrix changes in stented human coronary arteries. Circulation. 2004;110(8):940-7. D0I:10.1161/01. CIR. 0000139337.56084.30Del Pace S, Boddi M, Rasoini R, Micheli S, Alderighi C, Caciolli S et al. Acute infection-inflammation and coronary stent thrombosis: an observational study. Intern Emerg Med. 2010;5 (2):121-6. D0I:10.1007/s11739-010-0350-4Del Pace S, Boddi M, Rasoini R, Micheli S, Alderighi C, Caciolli S et al. Acute infection-inflammation and coronary stent thrombosis: an observational study. Intern Emerg Med. 2010;5 (2):121-6. D0I:10.1007/s11739-010-0350-4Chia S, Megson IL, Ludlam CA, Fox KA., Newby DE. Preserved endothelial vasomotion and fibrinolytic function in patients with acute stent thrombosis or in-stent restenosis. Thromb Res. 2003;111(6):343-9. PMID:14698651Chia S, Megson IL, Ludlam CA, Fox KA., Newby DE. Preserved endothelial vasomotion and fibrinolytic function in patients with acute stent thrombosis or in-stent restenosis. Thromb Res. 2003;111(6):343-9. PMID:14698651Niccoli G, Calvieri C, Flego D, Scalone G, Imaeva A, Sabato V et al. Allergic Inflammation Is Associated With Coronary Instability and a Worse Clinical 0utcome After Acute Myocardial Infarction. Circ Cardiovasc Interv. 2015;8(8): e002554. D0I:10.1161/CIRCINTERV ENTI0NS. 115.002554Niccoli G, Calvieri C, Flego D, Scalone G, Imaeva A, Sabato V et al. Allergic Inflammation Is Associated With Coronary Instability and a Worse Clinical 0utcome After Acute Myocardial Infarction. Circ Cardiovasc Interv. 2015;8(8): e002554. D0I:10.1161/CIRCINTERV ENTI0NS. 115.002554Leytin V, Mykhaylov S, Starkey AF, Allen DJ, Lau H, Ni H et al. Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia. Br J Haematol. 2006;133(1):78-82. D0I:10.1111/j. 13652141.2006.05981. xLeytin V, Mykhaylov S, Starkey AF, Allen DJ, Lau H, Ni H et al. Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia. Br J Haematol. 2006;133(1):78-82. D0I:10.1111/j. 13652141.2006.05981. xGabbasov ZA, Kozlov SG, Saburova OS, Titiov VN, Liakishev AA. [Stromal progenitor cells and blood leukocytes after implantation of drug-eluting stents]. Kardiologiia. 2010;50(1):36-41. PMID:20144156Gabbasov ZA, Kozlov SG, Saburova OS, Titiov VN, Liakishev AA. [Stromal progenitor cells and blood leukocytes after implantation of drug-eluting stents]. Kardiologiia. 2010;50(1):36-41. PMID:20144156Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 2003;9(11):1370-6. D01:10.1038/nm948Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 2003;9(11):1370-6. D01:10.1038/nm948Ganz P, Vita JA. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation. 2003;108(17):2049-53. D0I:10.1161/01. CIR. 0000089507.19675. F9Ganz P, Vita JA. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation. 2003;108(17):2049-53. D0I:10.1161/01. CIR. 0000089507.19675. F9Бернс С. А., Шмидт Е. А., Киприна Е. С., Барбараш О. Л., Веремеев А. В., Груздева О. В. и др. Предикторы тромбоза стента у больных с ОКС подъемом сегмента ST, подвергшихся первичной процедуре на коронарной артерии. Кардиология. 2011;51(4):10-5. [Berns S.A., Shmidt E.A., Kiprina E.S., Barbarash 0.L., Veremeev A.V., Gruzdeva O.V., Moiseenkov G.V Predictors of Stent Thrombosis in Patients With ST-Elevation Acute Coronary Syndrome Subjected to Primary Coronary Artery Intervention. Kardiologiia. 2011;51(4):10-5.]Бернс С. А., Шмидт Е. А., Киприна Е. С., Барбараш О. Л., Веремеев А. В., Груздева О. В. и др. Предикторы тромбоза стента у больных с ОКС подъемом сегмента ST, подвергшихся первичной процедуре на коронарной артерии. Кардиология. 2011;51(4):10-5. [Berns S.A., Shmidt E.A., Kiprina E.S., Barbarash 0.L., Veremeev A.V., Gruzdeva O.V., Moiseenkov G.V Predictors of Stent Thrombosis in Patients With ST-Elevation Acute Coronary Syndrome Subjected to Primary Coronary Artery Intervention. Kardiologiia. 2011;51(4):10-5.]Biondi-Zoccai GGL, Agostoni P, Sangiorgi GM, Airoldi F, Cosgrave J, Chieffo A et al. Incidence, predictors, and outcomes of coronary dissections left untreated after drug-eluting stent implantation. Eur Heart J. 2006;27(5 ) :540-6. D01:10.1093/eurheartj / ehi618Biondi-Zoccai GGL, Agostoni P, Sangiorgi GM, Airoldi F, Cosgrave J, Chieffo A et al. Incidence, predictors, and outcomes of coronary dissections left untreated after drug-eluting stent implantation. Eur Heart J. 2006;27(5 ) :540-6. D01:10.1093/eurheartj / ehi618Hoye A, Iakovou I, Ge L, van Mieghem CAG, 0ng ATL, Cosgrave J, et al. Long-term outcomes after stenting of bifurcation lesions with the «crush» technique: predictors ofan adverse outcome.J Am Coll Cardiol. 2006;47 (10):1949-58. D0I:10.1016/j. jacc. 2005.11.083Hoye A, Iakovou I, Ge L, van Mieghem CAG, 0ng ATL, Cosgrave J, et al. Long-term outcomes after stenting of bifurcation lesions with the «crush» technique: predictors ofan adverse outcome.J Am Coll Cardiol. 2006;47 (10):1949-58. D0I:10.1016/j. jacc. 2005.11.083Pfisterer M, Brunner-La Rocca HP, Buser PT, Rickenbacher P, Hunziker P, Mueller C et al. Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drugeluting versus bare-metal stents. J Am Coll Cardiol. 2006;48(12):2584 91. D0I:10.1016/j.jacc.2006.10.026Pfisterer M, Brunner-La Rocca HP, Buser PT, Rickenbacher P, Hunziker P, Mueller C et al. Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drugeluting versus bare-metal stents. J Am Coll Cardiol. 2006;48(12):2584 91. D0I:10.1016/j.jacc.2006.10.026ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery(EACTS) Developedwith the special contribution ofthe European Association of Percutaneous Cardiovascular Interventions (EAPCI). European Heart Journal. 2014;35(37):2541-619. D0I:10.1093/eur-heartj/ehu278ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery(EACTS) Developedwith the special contribution ofthe European Association of Percutaneous Cardiovascular Interventions (EAPCI). European Heart Journal. 2014;35(37):2541-619. D0I:10.1093/eur-heartj/ehu278Bliden KP, DiChiara J, Tantry US, Bassi AK, Chaganti SK, Gurbel PA. Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary inter vention: is the current antiplatelet therapy adequate? J Am Coll Cardiol. 2007;49(6):657-66. D0I:10.1016/j. jacc. 2006.10.050Bliden KP, DiChiara J, Tantry US, Bassi AK, Chaganti SK, Gurbel PA. Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary inter vention: is the current antiplatelet therapy adequate? J Am Coll Cardiol. 2007;49(6):657-66. D0I:10.1016/j. jacc. 2006.10.050Ellis SG, Colombo A, Grube E, Popma J, Koglin J, Dawkins KD et al. Incidence, timing, and correlates of stent thrombosis with the polymeric paclitaxel drug-eluting stent: a TAXUS II, IV, V, and VI meta-analysis of 3,445 patients followed for up to 3 years. J Am Coll Cardiol. 2007;49 (10):1043-51. D0I:10.1016/j. jacc. 2007.01.015Ellis SG, Colombo A, Grube E, Popma J, Koglin J, Dawkins KD et al. Incidence, timing, and correlates of stent thrombosis with the polymeric paclitaxel drug-eluting stent: a TAXUS II, IV, V, and VI meta-analysis of 3,445 patients followed for up to 3 years. J Am Coll Cardiol. 2007;49 (10):1043-51. D0I:10.1016/j. jacc. 2007.01.015Ge L, Airoldi F, Iakovou I, Cosgrave J, Michev I, Sangiorgi GM et al. Clinical and angiographic outcome after implantation of drug-eluting stents in bifurcation lesions with the crush stent technique: importance of final kissing balloon post-dilation. J Am Coll Cardiol. 2005;46 (4):613-20. D0I:10.1016/j. jacc. 2005.05.032Ge L, Airoldi F, Iakovou I, Cosgrave J, Michev I, Sangiorgi GM et al. Clinical and angiographic outcome after implantation of drug-eluting stents in bifurcation lesions with the crush stent technique: importance of final kissing balloon post-dilation. J Am Coll Cardiol. 2005;46 (4):613-20. D0I:10.1016/j. jacc. 2005.05.032Kuchulakanti PK, Chu WW, Torguson R, 0hlmann P, Rha S-W, Clavijo LC et al. Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents. Circulation. 2006;113 (8):1108-13. D0I:10.1161/ CIRCULATI0NAHA. 105.600155Kuchulakanti PK, Chu WW, Torguson R, 0hlmann P, Rha S-W, Clavijo LC et al. Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents. Circulation. 2006;113 (8):1108-13. D0I:10.1161/ CIRCULATI0NAHA. 105.600155Nebeker JR, Virmani R, Bennett CL, Hoffman JM, Samore MH, Alvarez J et al. Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. J Am Coll Cardiol. 2006;47 (1):175-81. D0I:10.1016/j. jacc. 2005.07.071Nebeker JR, Virmani R, Bennett CL, Hoffman JM, Samore MH, Alvarez J et al. Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. J Am Coll Cardiol. 2006;47 (1):175-81. D0I:10.1016/j. jacc. 2005.07.071Virmani R, Guagliumi G, Farb A, Musumeci G, Grieco N, Motta T et al. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation. 2004;109 (6):701-5. D0I:10.1161/01. CIR. 0000116202.41966. D4Virmani R, Guagliumi G, Farb A, Musumeci G, Grieco N, Motta T et al. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation. 2004;109 (6):701-5. D0I:10.1161/01. CIR. 0000116202.41966. D4Mauri L, Hsieh W, Massaro JM, Ho KKL, DAgostino R, Cutlip DE. Stent thrombosis in randomized clinical trials of drug-eluting stents. N EnglJMed. 2007;356 (10):1020-9. D0I:10.1056/NEJMoa067731Mauri L, Hsieh W, Massaro JM, Ho KKL, DAgostino R, Cutlip DE. Stent thrombosis in randomized clinical trials of drug-eluting stents. N EnglJMed. 2007;356 (10):1020-9. D0I:10.1056/NEJMoa067731Руда М. Я., Кузьмин А. И., Меркулова И. Н., Самко А. Н., Меркулов Е. В., Акашева Д. У. Спонтанная реперфузия артерии, ответственной за развитие ИМ, у больных ИМ с подъемом сегмента ST. Терапевтический архив. 2009;81(5):20-9. [Ruda M. Ya., Kuzmin A.I., Merkulova I.N., Samko A.N., Merkulov E.V, Sozykin A.V, Akasheva D.U. Spontaneous reperfusion of infact-related artery in patients with ST elevation myocardial infarction. Therapeutic archive. 2009;81(5):20-9.]Руда М. Я., Кузьмин А. И., Меркулова И. Н., Самко А. Н., Меркулов Е. В., Акашева Д. У. Спонтанная реперфузия артерии, ответственной за развитие ИМ, у больных ИМ с подъемом сегмента ST. Терапевтический архив. 2009;81(5):20-9. [Ruda M. Ya., Kuzmin A.I., Merkulova I.N., Samko A.N., Merkulov E.V, Sozykin A.V, Akasheva D.U. Spontaneous reperfusion of infact-related artery in patients with ST elevation myocardial infarction. Therapeutic archive. 2009;81(5):20-9.]Савченко А. П., Черкавская О. В., Руденко Б. А. Отдаленная клиническая эффективность эндоваскулярного лечения у больных ИБС с применением коронарных рапамицин-покрытых стентов Cypher. Вестник рентгенологии и радиологии. 2006;(6):4-17. [Savchenko А.P., Cherkavskaya О.V., Rudenko ВА., Bolotov Р.А. Long-term clinical efficiency of endovascular treatment using Cypher rapamycin-eluting stents in patients with coronary heart disease. Vestnik Rentgenologii i Radiologii. 2006;6:4-17.]Савченко А. П., Черкавская О. В., Руденко Б. А. Отдаленная клиническая эффективность эндоваскулярного лечения у больных ИБС с применением коронарных рапамицин-покрытых стентов Cypher. Вестник рентгенологии и радиологии. 2006;(6):4-17. [Savchenko А.P., Cherkavskaya О.V., Rudenko ВА., Bolotov Р.А. Long-term clinical efficiency of endovascular treatment using Cypher rapamycin-eluting stents in patients with coronary heart disease. Vestnik Rentgenologii i Radiologii. 2006;6:4-17.]Roffi M, Patrono C, Collet J-P, Mueller C, Valgimigli M, Andreotti F et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37(3):267-315. D0I:10.1093/eurheartj/ehv320Roffi M, Patrono C, Collet J-P, Mueller C, Valgimigli M, Andreotti F et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37(3):267-315. D0I:10.1093/eurheartj/ehv320Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-77. D0I:10.1093/eur-heartj/ehx393Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-77. D0I:10.1093/eur-heartj/ehx393Valgimigli M, Bueno H, Byrne RA., Collet J-P, Costa F, Jeppsson A et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTs). Eur Heart J. 2018;39(3):213-60. D0I:10.1093/eurheartj/ ehx419Valgimigli M, Bueno H, Byrne RA., Collet J-P, Costa F, Jeppsson A et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTs). Eur Heart J. 2018;39(3):213-60. D0I:10.1093/eurheartj/ ehx419Costa F, van Klaveren D, James S, Heg D, Räber L, Feres F, et al. Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-individual-patient datasets from clinical trials. Lancet. 2017;389 (10073):1025-34. D0I:10.1016/S0140-6736 (17) 30397-5Costa F, van Klaveren D, James S, Heg D, Räber L, Feres F, et al. Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-individual-patient datasets from clinical trials. Lancet. 2017;389 (10073):1025-34. D0I:10.1016/S0140-6736 (17) 30397-5Чесникова А. И. Возможности повышения эффективности лечения ИБС: от аспирина к тикагрелору. Сердце: журнал для практикующих врачей. 2013; 12 (1/ (69)):3-12. [Chesnikova A.I. Efficacy potential of the treatment of coronary heart disease: from aspirine to ticagrelor. Russian Heart Journal. 2013;12(1):3-12.]Чесникова А. И. Возможности повышения эффективности лечения ИБС: от аспирина к тикагрелору. Сердце: журнал для практикующих врачей. 2013; 12 (1/ (69)):3-12. [Chesnikova A.I. Efficacy potential of the treatment of coronary heart disease: from aspirine to ticagrelor. Russian Heart Journal. 2013;12(1):3-12.]Пучиньян Н. Ф., Фурман Н. В., Малинова Л. И., Долотовская П. В. Проблема контроля эффективности антитромбоцитарной терапии в кардиологической практике. Рациональная фармакотерапия в кардиологии. 2017;13(1):107-15. [Puchinian N.F., Furman N.V, Malinova L.I., Dolotovskaya P.V. Monitoring of the effectiveness of antiplatelet therapy in cardiology practice. Rational Pharmacotherapy in Cardiology. 2017;13(1):107-115.]Пучиньян Н. Ф., Фурман Н. В., Малинова Л. И., Долотовская П. В. Проблема контроля эффективности антитромбоцитарной терапии в кардиологической практике. Рациональная фармакотерапия в кардиологии. 2017;13(1):107-15. [Puchinian N.F., Furman N.V, Malinova L.I., Dolotovskaya P.V. Monitoring of the effectiveness of antiplatelet therapy in cardiology practice. Rational Pharmacotherapy in Cardiology. 2017;13(1):107-115.]Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C et al. ESC Guidelines for the management ofacute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33(20):2569-619. D0I:10.1093/eurheartj/ehs215Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C et al. ESC Guidelines for the management ofacute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33(20):2569-619. D0I:10.1093/eurheartj/ehs215Комаров А. Л. Оценка чувствительности к клопидогрелу: современное состояние проблемы. Атеротромбоз. 2015; (2):95-106. / [Komarov A. L. 0cenka chuvstvitel'nosti k klopidogrelu: sovremennoe sostoyanie problemy. Atherothrombosis Journal. 2015;2:95-106. [In Russ.]]Комаров А. Л. Оценка чувствительности к клопидогрелу: современное состояние проблемы. Атеротромбоз. 2015; (2):95-106. / [Komarov A. L. 0cenka chuvstvitel'nosti k klopidogrelu: sovremennoe sostoyanie problemy. Atherothrombosis Journal. 2015;2:95-106. [In Russ.]]Kei AA, Florentin M, Mikhailidis DP, Elisaf MS, Liberopoulos EN. Review: Antiplatelet drugs: what comes next? Clin Appl Thromb Hemost. 2011;17 (1):9-26. D0I:10.1177/1076029610385222Kei AA, Florentin M, Mikhailidis DP, Elisaf MS, Liberopoulos EN. Review: Antiplatelet drugs: what comes next? Clin Appl Thromb Hemost. 2011;17 (1):9-26. D0I:10.1177/1076029610385222Aradi D, Storey RF, Komocsi A, Trenk D, Gulba D, Kiss RG et al. Expert position paper on the role ofplatelet function testing in patients undergoing percutaneous coronary intervention. Eur Heart J. 2014;35 (4):209 15. D0I:10.1093/eurheartjeht375/Aradi D, Storey RF, Komocsi A, Trenk D, Gulba D, Kiss RG et al. Expert position paper on the role ofplatelet function testing in patients undergoing percutaneous coronary intervention. Eur Heart J. 2014;35 (4):209 15. D0I:10.1093/eurheartjeht375/Явелов И. С. Роль определения функциональной активности тромбоцитов при применении клопидогрела в практике лечения больных с коронарной болезнью сердца. Атеротромбоз. 2014;(1):22-32. [Yavelov I. S. Rol opredeleniya funktsionalnoy aktivnosti trombotsitov pri primenenii klopidogrela v praktike lecheniya bolnyih s koronarnoy boleznyu serdtsa. Atherothrombosis Journal. 2014;(1):22-32. [In Russ.]] D0I:10.21518/2307-1109-2014-1-22-32Явелов И. С. Роль определения функциональной активности тромбоцитов при применении клопидогрела в практике лечения больных с коронарной болезнью сердца. Атеротромбоз. 2014;(1):22-32. [Yavelov I. S. Rol opredeleniya funktsionalnoy aktivnosti trombotsitov pri primenenii klopidogrela v praktike lecheniya bolnyih s koronarnoy boleznyu serdtsa. Atherothrombosis Journal. 2014;(1):22-32. [In Russ.]] D0I:10.21518/2307-1109-2014-1-22-32Комаров А. Л., Панченко Е. П. Тестирование функции тромбоцитов для оценки риска тромбозов и кровотечений у больных иБс, получающих антиагреганты. Российский кардиологический журнал. 252015;(3 (119)):25-34. [Komarov A. L., Panchenko E. P. Platelet function test for the assessment of thrombosis and bleeding risk in CHD patients taking antiplatelet medications. Russian journal of cardiology. 2015;3(119):25-34.]Комаров А. Л., Панченко Е. П. Тестирование функции тромбоцитов для оценки риска тромбозов и кровотечений у больных иБс, получающих антиагреганты. Российский кардиологический журнал. 252015;(3 (119)):25-34. [Komarov A. L., Panchenko E. P. Platelet function test for the assessment of thrombosis and bleeding risk in CHD patients taking antiplatelet medications. Russian journal of cardiology. 2015;3(119):25-34.]Eikelboom JW, Hirsh J, Spencer FA, Baglin TP, Weitz JI. Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines./Chest. 2012;141(2 Suppl):e89S-e119S. D0I:10.1378/ chest.11-2293Eikelboom JW, Hirsh J, Spencer FA, Baglin TP, Weitz JI. Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines./Chest. 2012;141(2 Suppl):e89S-e119S. D0I:10.1378/ chest.11-2293Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045-57. D01:10.1056/NEJMoa0904327Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045-57. D01:10.1056/NEJMoa0904327Becker RC, Bassand JP, Budaj A, Wojdyla DM, James SK, Cornel JH et al. Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient 0utcomes (PLAT0) trial. Eur Heart J. 2011;32(23):2933-44. D0I:10.1093/eur-heartj/ehr422Becker RC, Bassand JP, Budaj A, Wojdyla DM, James SK, Cornel JH et al. Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient 0utcomes (PLAT0) trial. Eur Heart J. 2011;32(23):2933-44. D0I:10.1093/eur-heartj/ehr422DiNicolantonio JJ, D»Ascenzo F, Tomek A, Chatterjee S, Niazi AK, Biondi-Zoccai G. Clopidogrel is safer than ticagrelor in regard to bleeds: a closer look at the PLAT0 trial. Int J Cardiol. 2013;168(3):1739-44. D01:10.1016/j. ijcard. 2013.06.135DiNicolantonio JJ, D»Ascenzo F, Tomek A, Chatterjee S, Niazi AK, Biondi-Zoccai G. Clopidogrel is safer than ticagrelor in regard to bleeds: a closer look at the PLAT0 trial. Int J Cardiol. 2013;168(3):1739-44. D01:10.1016/j. ijcard. 2013.06.135Drug Approval Package: Brilinta (ticagrelor) NDA #022433 [Internet]. 2011 [cited 2018].Drug Approval Package: Brilinta (ticagrelor) NDA #022433 [Internet]. 2011 [cited 2018].Sahlen A, Varenhorst C, Lagerqvist B, Renlund H, 0merovic E, Erlinge D et al. 0utcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction: experiences from SWEDEHEART registry. Eur Heart J. 2016;37(44):3335-42. D0I:10.1093/eurheartj/ehw284Sahlen A, Varenhorst C, Lagerqvist B, Renlund H, 0merovic E, Erlinge D et al. 0utcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction: experiences from SWEDEHEART registry. Eur Heart J. 2016;37(44):3335-42. D0I:10.1093/eurheartj/ehw284De Lemos JA, Brilakis ES. No free lunches: balancing bleeding and efficacy with ticagrelor. Eur HeartJ. 2011;32(23):2919-21. D0I:10.1093/ eurheartj/ehr424De Lemos JA, Brilakis ES. No free lunches: balancing bleeding and efficacy with ticagrelor. Eur HeartJ. 2011;32(23):2919-21. D0I:10.1093/ eurheartj/ehr424Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502. D0I:10.1056/NEJMoa010746Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502. D0I:10.1056/NEJMoa010746Roe MT, Armstrong PW, Fox KAA, White HD, Prabhakaran D, Goodman SG et al. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med. 2012;367(14):1297-309. D0I:10.1056/NEJMoa1205512Roe MT, Armstrong PW, Fox KAA, White HD, Prabhakaran D, Goodman SG et al. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med. 2012;367(14):1297-309. D0I:10.1056/NEJMoa1205512Boggon R, van Staa TP, Timmis A, Hemingway H, Ray KK, Begg A et al. Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction --a hospital registry-primary care linked cohort (MINAP-GPRD). Eur Heart J. 2011;32(19):2376-86. D0I:10.1093/eurheartj/ehr340Boggon R, van Staa TP, Timmis A, Hemingway H, Ray KK, Begg A et al. Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction --a hospital registry-primary care linked cohort (MINAP-GPRD). Eur Heart J. 2011;32(19):2376-86. D0I:10.1093/eurheartj/ehr340Эрлих А. Д., Грацианский Н. А. Результаты шестимесячного наблюдения за больными с ОКС в Российском регистре Рекорд. Кардиология. 2011;51(12):11-6. [Erlikh A.D., Gratsiansky N.A. on Behalf of the REC0RD Registry Participants. Six Months Results of the Russian Independent Registry of Acute Coronary Syndromes REC0RD. Kardiologiia. 2011;51(12):11-6.]Эрлих А. Д., Грацианский Н. А. Результаты шестимесячного наблюдения за больными с ОКС в Российском регистре Рекорд. Кардиология. 2011;51(12):11-6. [Erlikh A.D., Gratsiansky N.A. on Behalf of the REC0RD Registry Participants. Six Months Results of the Russian Independent Registry of Acute Coronary Syndromes REC0RD. Kardiologiia. 2011;51(12):11-6.]Шевченко И. И., Эрлих А. Д., Исламов Р. Р., Будяк В. А., Провоторов В. М., Грацианский Н. А. Сравнение данных регистров ОКС РЕКОРД и РЕКОРД-2: лечение и его исходы в стационарах, не имеющих возможности выполнения инвазивных коронарных процедур. Кардиология. 2013;53(8):4-10. [Shevchenko I.I., Erlikh A.D., Islamov R.R., Budyak V.A., Provotorov V.M., Gratsiansky N.A. on Behalf of Participants of REC0RD and REC0RD-2 Registries. Comparison of data from registries of acute coronary syndromes REC0RD and REC0RD-2: management of patients and its results in noninvasive hospitals. Kardiologiia. 2013;53(8):4-10.]Шевченко И. И., Эрлих А. Д., Исламов Р. Р., Будяк В. А., Провоторов В. М., Грацианский Н. А. Сравнение данных регистров ОКС РЕКОРД и РЕКОРД-2: лечение и его исходы в стационарах, не имеющих возможности выполнения инвазивных коронарных процедур. Кардиология. 2013;53(8):4-10. [Shevchenko I.I., Erlikh A.D., Islamov R.R., Budyak V.A., Provotorov V.M., Gratsiansky N.A. on Behalf of Participants of REC0RD and REC0RD-2 Registries. Comparison of data from registries of acute coronary syndromes REC0RD and REC0RD-2: management of patients and its results in noninvasive hospitals. Kardiologiia. 2013;53(8):4-10.]Эрлих А. Д., Мацкеплишвили С. Т., Грацианский Н. А., Бузиашвили Ю. И. Первый московский регистр ОКС: характеристика больных, лечение и исходы за время пребывания в стационаре. Кардиология. 2013;53 (12):4-13. [Erlikh A. D., Matskeplishvili S. T., Gratsiansky N. A., Buziashvili Yu. I. First Moscow “Snapshot” register of acute coronary syndromes: characteristics of patients, management and outcomes during hospitalization. Kardiologiia. 2013;53 (12):4-13.]Эрлих А. Д., Мацкеплишвили С. Т., Грацианский Н. А., Бузиашвили Ю. И. Первый московский регистр ОКС: характеристика больных, лечение и исходы за время пребывания в стационаре. Кардиология. 2013;53 (12):4-13. [Erlikh A. D., Matskeplishvili S. T., Gratsiansky N. A., Buziashvili Yu. I. First Moscow “Snapshot” register of acute coronary syndromes: characteristics of patients, management and outcomes during hospitalization. Kardiologiia. 2013;53 (12):4-13.]Эрлих А. Д. Двойная антитромбоцитарная терапия: необходимость приверженности к лечению и возможности ее повышения. Атеротромбоз. 2014; (2):25-33. [Erlikh A. D. Dvoynaya antitromboticheskaya terapiya: neobhodimost priverzhennosti k lecheniyu i vozmozhnosti ee povyisheniya. Atherothrombosis Journal. 2014;(2):25-33. [In Russ.]] D01:10.21518/2307-1109-2014-2-1-13Эрлих А. Д. Двойная антитромбоцитарная терапия: необходимость приверженности к лечению и возможности ее повышения. Атеротромбоз. 2014; (2):25-33. [Erlikh A. D. Dvoynaya antitromboticheskaya terapiya: neobhodimost priverzhennosti k lecheniyu i vozmozhnosti ee povyisheniya. Atherothrombosis Journal. 2014;(2):25-33. [In Russ.]] D01:10.21518/2307-1109-2014-2-1-13Varenhorst C, Jensevik K, Jernberg T, Sundström A, Hasvold P, Held C et al. Duration of dual antiplatelet treatment with clopidogrel and aspirin in patients with acute coronary syndrome. Eur Heart J. 2014;35(15):969-78. D0I:10.1093/eurheartj/eht438Varenhorst C, Jensevik K, Jernberg T, Sundström A, Hasvold P, Held C et al. Duration of dual antiplatelet treatment with clopidogrel and aspirin in patients with acute coronary syndrome. Eur Heart J. 2014;35(15):969-78. D0I:10.1093/eurheartj/eht438Mehran R, Baber U, Steg PG, Ariti C, Weisz G, Witzenbichler B et al. Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study. Lancet. 2013;382 (9906):1714-22. D01:10.1016/S0140-6736 (13) 61720-1Mehran R, Baber U, Steg PG, Ariti C, Weisz G, Witzenbichler B et al. Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study. Lancet. 2013;382 (9906):1714-22. D01:10.1016/S0140-6736 (13) 61720-1Rossini R, Capodanno D, Lettieri C, Musumeci G, Nijaradze T, Romano M et al. Prevalence, predictors, and long-term prognosis of premature discontinuation of oral antiplatelet therapy after drug eluting stent implantation. Am J Cardiol. 2011; 107(2): 186-94. D0I:10.1016/j.amjcard.2010.08.067Rossini R, Capodanno D, Lettieri C, Musumeci G, Nijaradze T, Romano M et al. Prevalence, predictors, and long-term prognosis of premature discontinuation of oral antiplatelet therapy after drug eluting stent implantation. Am J Cardiol. 2011; 107(2): 186-94. D0I:10.1016/j.amjcard.2010.08.067Ferreira-Gonzalez I, Marsal JR, Ribera A, Permanyer-Miralda G, Garcia-Del Blanco B, Marti G et al. Background, incidence, and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation. Circulation. 2010;122(10):1017-25. D0I:10.1161/CIRCULATI0NAHA. 110.938290Ferreira-Gonzalez I, Marsal JR, Ribera A, Permanyer-Miralda G, Garcia-Del Blanco B, Marti G et al. Background, incidence, and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation. Circulation. 2010;122(10):1017-25. D0I:10.1161/CIRCULATI0NAHA. 110.938290

The authors declare that there are no conflicts of interest present.