cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2020.5.n869cardio-869Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИRESEARCH ARTICLESПовышение артериальной жесткости у пациентов с субклинической формой болезни Бехчета на основании оценки каротидно-феморальной скорости распространения пульсовой волныIncreased Arterial Stiffness Measured By Carotid Femoral (Aortic) Pulse Wave Velocity In Patients with Inactive Behçet’s Diseasehttps://orcid.org/0000-0002-5882-0525АгусХиджаз ЗенкиранZencirkiran AgusHicaz

MD

hicazincir@yahoo.comЙылдызБану СахинYildizBanu Sahin

MD

yildizim76@yahoo.comhttps://orcid.org/0000-0003-2796-0987КахраманСерканKahramanSerkan

MD

serkankahraman_86@outlook.comКалканКубраKalkanKubra

MD

kbraerol@yahoo.comАладагНазир БаскуртAladagNazire Baskurt

MD

drnazirealadag@yahoo.comhttps://orcid.org/0000-0003-3502-4785ЙилдизМустафаYildizMustafa

PhD

mustafayilldiz@yahoo.comСтамбульский университет им. Саглыка Билимлери, Мехмет Акиф, Больница кардиологии и сердечно-сосудистой хирургии им. Эрси, отделение кардиологии, Стамбул, ТурцияТурцияIstanbul Sağlık Bilimleri Univercity Mehmet Akif Ersoy Cardiology and Cardiovascular Surgery Hospital, Department of Cardiology, Istanbul, TurkeyTurkeyКартал Учебно-исследовательская больница им. Лютфи Кырдар, внутренняя медицина, ТурцияТурцияKartal Lutfi Kirdar Training and Research Hospital,Internal Medicine, TurkeyTurkeyТракский университет, отделение ревматологии, ТурцияТурцияTrakya Univercity, Rheumatology Department, TurkeyTurkeyКартал Учебно-исследовательская больница им. Лютфи Кырдар, внутренняя медицина, ТурцияТурцияKartal Lutfi Kirdar Training and Research Hospital,Internal MedicineTurkey202003062020605123–127Copyright © Kardiomag, 20202020KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/869

Актуальность Болезнь Бехчета (ББ) - это хроническое мультисистемное заболевание, характеризующееся поражением сосудов. Острые и хронические воспалительные процессы, связанные с ББ, могут вызвать эндотелиальную дисфункцию, которая затем может привести к последующему увеличению артериальной жесткости и изменению скорости распространения пульсовой волны (СПВ).Цель Оценка измерений СПВ у пациентов с неактивной ББ и лиц из группы контроля.Материалы и методы Было изучено 50 пациентов с неактивной ББ и 49 здоровых добровольцев без известных сердечно-сосудистых заболеваний. СПВ между сонной и бедренной артерией (каротидно-феморальная СПВ, кфСПВ) была определена у всех пациентов одним и тем же специалистом-исследователем с использованием прибора Complior (Colson, Paris, France).Результаты Средняя продолжительность болезни составила 3,23±2,31 года. Пациенты с ББ (средний возраст 36,04±9,94 лет) имели значительно более высокие уровни кфСПВ по сравнению с контролем (9,57±1,88 против 8,47±1,13 м/с; p=0,003). Было установлено, что СПВ положительно коррелирует с возрастом, систолическим, диастолическим, средним артериальным давлением, обхватом талии и соотношением талия/бедра.Выводы В настоящем исследовании продемонстрировано, что у пациентов с неактивной ББ по сравнению со здоровыми лицами значительно повышена артериальная жесткость, оцененная по увеличению кфСПВ.

Introduction Behçet’s disease (BD) is a chronic, multisystemic disease characterised by vascular involvement. Acute and chronic inflammatory processes associated with BD may cause endothelial dysfunction, which can then lead to a subsequent increase of arterial stiffness and altered pressure wave reflections. The aim of this study was to evaluate the pulse wave velocity (PWV) measurements in patients with inactive BD and control subjects.Methods We studied 50 patients with inactive BD and 49 healthy control subjects without known cardiovascular disease. Carotid-femoral PWV was determined in all subjects by the same expert research clinician using Complior device (Colson, Paris, France).Results Mean disease duration was 3.23±2.31 years. Patients with BD (mean age 36.04±9.94 years) had significantly higher PWV levels compared to controls (9.57±1.88 vs. 8.47±1.13 m / s; p=0,003). PWV was found to be positively correlated with age, systolic, diastolic, mean blood pressure, waist, and waist / hip ratio.Conclusion In our study we demonstrated that patients with BD exhibit significantly increased arterial stiffness assessed by increased carotid-femoral PWV compared to healthy control subjects.

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The authors declare that there are no conflicts of interest present.