cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2018.1.10083cardio-84Research ArticleПРАКТИЧЕСКАЯ КАРДИОЛОГИЯ ПРИЛОЖЕНИЕ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ. КЛИНИЧЕСКИЕ СЕМИНАРЫPRACTICAL CARDIOLOGY SUPPLEMENT FOR PRACTISING PHYSICIANS. CLINICAL SEMINARSМикроРНК как биомаркеры сердечно-сосудистых заболеванийMicroRNAs as Biomarkers of Cardiovascular DiseasesРомакинаВ. В.RomakinaV. V.noemail@neicon.ruЖировИ. В.ZhirovIgor V.izhirov@mail.ruНасоноваС. Н.NasonovaS. N.noemail@neicon.ruЗасееваА. В.ZaseevaA. V.noemail@neicon.ruКочетовА. Г.KochetovA. G.noemail@neicon.ruЛянгО. В.LiangO. V.noemail@neicon.ruТерещенкоС. Н.TereshchenkoS. N.noemail@neicon.ruФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РФРоссияInstitute of Cardiology of National Medical Research Center for CardiologyRussian FederationФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РФ; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РФРоссияInstitute of Cardiology of National Medical Research Center for CardiologyRussian FederationФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РФ; Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»РоссияInstitute of Cardiology of National Medical Research Center for Cardiology; Peoples Friendship University of Russia (RUDN University)Russian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»РоссияPeoples Friendship University of Russia (RUDN University)Russian FederationФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РФ; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РФРоссияInstitute of Cardiology of National Medical Research Center for Cardiology; Medical Academy of Continuing Education Russian Medical Academy of Postgraduate EducationRussian Federation2018181120185816671Copyright © Kardiomag, 20182018KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/84

В настоящее время нет сомнений в том, что важную роль в развитии и патогенезе сердечно-сосудистых заболеваний (ССЗ) играют микроРНК. Обнаружение существенных изменений уровня экспрессии данных молекул при различных заболеваниях позволяет рассматривать их в качестве потенциальных биомаркеров заболеваний человека, в том числе сердечной недостаточности. Изучение механизмов взаимосвязи между ССЗ и уровнем экспрессии различных микроРНК, а также установление их точных взаимосвязей с генами является актуальной проблемой и требует дальнейших исследований.

The fact that microRNAs play an important role in the development and pathogenesis of cardiovascular disease is beyond doubt. This article provides a brief overview of recent data that relate to microRNA expression in various cardiovascular diseases. Detecting significant changes in the level of expression of these molecules in various diseases means that microRNAs can be considered to be potential biomarkers of human pathologies including heart failure. Studying the relationship between the mechanisms of cardiovascular disease and the level of expression of a variety of microRNAs, as well as establishing their exact relationships with the genes is an urgent problem and requires further research.

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The authors declare that there are no conflicts of interest present.