cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2018.1.10081cardio-82Research ArticleОБЗОРЫREVIEWSПродолжительность двухкомпонентной антиагрегантной терапии у больных ишемической болезнью сердца после имплантации эндоваскулярного стентаDuration of Dual Antiplatelet Therapy in Patients With Ischemic Heart Disease After Implantation of Endovascular StentsСумароковА. Б.SumarokovAlexander B.vokoramus@mail.ruБурячковскаяЛ. И.BuryachkovskayaL. I.noemail@neicon.ruЛомакинН. В.LomakinN. V.noemail@neicon.ruДоценкоЮ. В.DotsenkoYu. V.noemail@neicon.ruУчительИ. А.UchitelI. A.noemail@neicon.ruТимофееваЛ. А.TimofeevaL. A.noemail@neicon.ruФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РФРоссияNational Medical Research Center for CardiologyRussian FederationФГБУ «Центральная клиническая больница с поликлиникой» УД Президента РФРоссияCentral Clinical Hospital with Policlinic of the Presidential Administration of the Russian FederationRussian Federation2018181120185814152Copyright © Kardiomag, 20182018KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/82

Оптимальные сроки проведения длительной двухкомпонентной антитромбоцитарной терапии (ДАТ) после имплантации коронарного стента с лекарственным покрытием остаются неясными, так как у отдельных больных после завершения рекомендуемого курса ДАТ сохраняется риск развития тромботических осложнений, опасность тромбоза стента. В то же время существует реальная угроза кровотечений на фоне ДАТ. В обзорной работе представлены результаты клинических исследований по проблеме длительности ДАТ и данные мета-анализов. Рассмотрены вопросы продолжительности ДАТ в рекомендациях Американской ассоциации сердца и Американской коллегии кардиологов (AHA/ACC) 2016 года.

Optimal duration of dual antiplatelet therapy (DAPT) after stent implantation is uncertain. Some patients have an extended risk of thrombotic complications including that of very late stent thrombosis after cessation of recommended course of DAPT (6-12 months). On the other hand, there is a real risk of bleeding on DAPT. In this review, we present and discuss results of clinical trials of long-term DAPT and data of their meta-analyses. The review also contains consideration of some aspects of new AHA /ACC recommendations (2016) on duration of DAPT.

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The authors declare that there are no conflicts of interest present.