cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.n765cardio-765Research ArticleОБЗОРЫREVIEWSsST2- биомаркер для оценки прогноза и мониторирования больных декомпенсированной сердечной недостаточностьюSoluble ST2 – biomarker for prognosis and monitoring in decompensated heart failureСкворцовА. А.SkvortsovA. A.

121552, Москва, ул. 3-я Черепковская, 15а

3rd Cherepkovskaya 15a, Moscow 121552

skvortsov00@yandex.ruНарусовО. Ю.NarusovO. Yu.

121552, Москва, ул. 3-я Черепковская, 15а

3rd Cherepkovskaya 15a, Moscow 121552

drnarusov@yandex.ruМуксиноваМ. Д.MuksinovaM. D.

3rd Cherepkovskaya 15a, Moscow 121552

marisha-92@hotmail.comФГБУ "НМИЦ кардиологии" Минздрава РоссииРоссияFSBO National Medical research center of cardiology of the Ministry of healthcare of the Russian FederationRussian Federation2019211020195911S1827Copyright © Kardiomag, 20192019KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/765

Обзорная статья посвящена значению определения концентраций нового биомаркера sST2 для оценки прогноза и мониторирования эффективности лечения больных декомпенсированной сердечной недостаточностью во время эпизода декомпенсации и при длительном наблюдении после выписки из стационара. В статье детально проанализирована целесообразность определения концентраций sST2 у больного ОДСН во время госпитализации, при поступлении и выписке из клиники, показано значение изменения уровня биомаркера за период активного лечения для стратификации риска пациентов, представлены оптимальные пороговые значения sST2, на которые следует ориентироваться при выделении больных высокого и очень высокого риска. Подчеркнута важность последующего мониторирования концентрации маркера при длительном наблюдении для предопределения риска развития смерти, повторной декомпенсации/госпитазизации из-за СН, показаны потенциальные преимущества выбора sST2 в качестве наиболее оптимального маркера для серийного измерения при длительном наблюдении, также как и оценки эффективности проводимого лечения больных СН по сравнению с «классическим» вариантом – натрийуретическими пептидами.

The review aims to appraise the value of determining the concentrations of the new biomarker sST2 for assessing prognosis and monitoring treatment effectiveness of patients with decompensated heart failure during an episode of decompensation and during long-term follow-up after discharge from the hospital. The article analyses in detail the expedience of sST2 measurement in a patient with ADHF on admission and discharge from the hospital and the changes in the biomarker level during the period of active treatment for risk-stratification in patients, presents the optimal threshold values of sST2, which should be oriented when selecting patients with high and very high risk. The importance of subsequent monitoring of the marker concentration during long-term observation in emphasized to predict the risk of death, HF re-decompensation / HF rehospitalization. The potential benefits of choosing sST2 as the optimal marker for serial measurement during long-term follow-up, as well as evaluating the treatment effectiveness in patients with HF, compared to the “classical” variant - natriuretic peptides are shown.

 

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The authors declare that there are no conflicts of interest present.