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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardio</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиология</journal-title><trans-title-group xml:lang="en"><trans-title>Kardiologiia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0022-9040</issn><issn pub-type="epub">2412-5660</issn><publisher><publisher-name>Kardiomag</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18087/cardio.2017.12.10060</article-id><article-id custom-type="elpub" pub-id-type="custom">cardio-74</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИЧЕСКАЯ КАРДИОЛОГИЯ ПРИЛОЖЕНИЕ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ. КЛИНИЧЕСКИЕ СЕМИНАРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL CARDIOLOGY SUPPLEMENT FOR PRACTISING PHYSICIANS. CLINICAL SEMINARS</subject></subj-group></article-categories><title-group><article-title>Новые возможности в лечении больных со стабильными проявлениями атеротромбоза</article-title><trans-title-group xml:lang="en"><trans-title>New Possibilities in the Treatment of Patients With Stable Manifestations of Atherothrombosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панченко</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Panchenko</surname><given-names>Elizaveta P.</given-names></name></name-alternatives><email xlink:type="simple">lizapanchenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>«Институт кардиологии им. А.Л. Мясникова» ФГБУ «Национальный медицинский исследовательский центр кардиологии» МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Cardiology im. A. L. Myasnikova NMI of National Medical Research Center for Cardiology of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2018</year></pub-date><volume>57</volume><issue>12</issue><fpage>82</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kardiomag, 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Kardiomag</copyright-holder><copyright-holder xml:lang="en">Kardiomag</copyright-holder><license xlink:href="https://cardio.elpub.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://cardio.elpub.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://cardio.elpub.ru/jour/article/view/74">https://cardio.elpub.ru/jour/article/view/74</self-uri><kwd-group xml:lang="ru"><kwd>атеротромбоз</kwd><kwd>лечение</kwd><kwd>новые возможности</kwd><kwd>atherothrombosis</kwd><kwd>treatment</kwd><kwd>new possibilities</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Cardiovascular diseases. WHO; 2016.</mixed-citation><mixed-citation xml:lang="en">WHO. Cardiovascular diseases. WHO; 2016.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rosamond W., Flegal К., Furie К. et al. Heart Disease and Stroke Statistics-2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcomittee. Circulation 2008; 117: e25 - e146.</mixed-citation><mixed-citation xml:lang="en">Rosamond W., Flegal К., Furie К. et al. Heart Disease and Stroke Statistics-2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcomittee. Circulation 2008; 117: e25 - e146.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Nichols M., Townsend N., Scarborough, Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J. 2014; 35: 2950-2959.</mixed-citation><mixed-citation xml:lang="en">Nichols M., Townsend N., Scarborough, Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J. 2014; 35: 2950-2959.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Benjamin E.J. Blaha M.J., Chiuve S.E. et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation 2017; 135; e146 - e603.</mixed-citation><mixed-citation xml:lang="en">Benjamin E.J. Blaha M.J., Chiuve S.E. et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation 2017; 135; e146 - e603.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Демография: Федеральная служба государственной статистики</mixed-citation><mixed-citation xml:lang="en">Демография: Федеральная служба государственной статистики</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez A.D., Mathers C.D., Ezzati M., et al. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006; 367; 1747-1757.</mixed-citation><mixed-citation xml:lang="en">Lopez A.D., Mathers C.D., Ezzati M., et al. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006; 367; 1747-1757.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Комаров А.Л., Панченко Е.П., Деев А.Д. и др. Течение перемежающейся хромоты и прогноз больных атеросклеротическим поражением артерий нижних конечностей. Анализ результатов проспективного наблюдения. Ангиология и сосудистая хирургия 2000; 2: 9-19</mixed-citation><mixed-citation xml:lang="en">Комаров А.Л., Панченко Е.П., Деев А.Д. и др. Течение перемежающейся хромоты и прогноз больных атеросклеротическим поражением артерий нижних конечностей. Анализ результатов проспективного наблюдения. Ангиология и сосудистая хирургия 2000; 2: 9-19</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dormandy J., Mahir H., Ascady G. et al. Fate of the patient with chronic leg ischemia. J. Cardiovasc Surg 1989; 30: 50-57.</mixed-citation><mixed-citation xml:lang="en">Dormandy J., Mahir H., Ascady G. et al. Fate of the patient with chronic leg ischemia. J. Cardiovasc Surg 1989; 30: 50-57.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Smith G.D., Shipley M.J. Intermittent claudication, heart disease risk factors, and mortality: The Whitehall Study. Circulation 1990; 82: 1925-1931.</mixed-citation><mixed-citation xml:lang="en">Smith G.D., Shipley M.J. Intermittent claudication, heart disease risk factors, and mortality: The Whitehall Study. Circulation 1990; 82: 1925-1931.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Панченко Е.П. Результаты трехлетнего наблюдения за амбулаторными больными с клиническими проявлениями атеротромбоза (анализ российской популяции регистра REACH) Кардиология 2009; 10: 9-14</mixed-citation><mixed-citation xml:lang="en">Панченко Е.П. Результаты трехлетнего наблюдения за амбулаторными больными с клиническими проявлениями атеротромбоза (анализ российской популяции регистра REACH) Кардиология 2009; 10: 9-14</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ph. Gabriel Steg, MD; Deepak L. Bhatt, MD; Peter W. F. Wilson, MD; et al. One-Year Cardiovascular Event Rates in Outpatients With Atherothrombosis JAMA 2007; 297: 1197-1206.</mixed-citation><mixed-citation xml:lang="en">Ph. Gabriel Steg, MD; Deepak L. Bhatt, MD; Peter W. F. Wilson, MD; et al. One-Year Cardiovascular Event Rates in Outpatients With Atherothrombosis JAMA 2007; 297: 1197-1206.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Borissoff J.I., Spronk H.M., Heeneman H.S., ten Cate H. Is thrombin a key player in the 'coagulation-atherogenesis'maze? Cardiovasc Res 2009; 82: 392-403.</mixed-citation><mixed-citation xml:lang="en">Borissoff J.I., Spronk H.M., Heeneman H.S., ten Cate H. Is thrombin a key player in the 'coagulation-atherogenesis'maze? Cardiovasc Res 2009; 82: 392-403.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Deepak L. Bhatt, M.D., Keith A.A. Fox, M.B., Ch.B. et al. Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. N. Engl J. Med 2006; 354: 1706-1717.</mixed-citation><mixed-citation xml:lang="en">Deepak L. Bhatt, M.D., Keith A.A. Fox, M.B., Ch.B. et al. Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. N. Engl J. Med 2006; 354: 1706-1717.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation. N. Engl J. Med 2001; 345: 494-502.</mixed-citation><mixed-citation xml:lang="en">The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation. N. Engl J. Med 2001; 345: 494-502.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt, M.D., Keith A.A. Fox, M.B., Ch.B. et al. Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. N. Engl J. Med 2006; 354: 1706-1717.</mixed-citation><mixed-citation xml:lang="en">Bhatt, M.D., Keith A.A. Fox, M.B., Ch.B. et al. Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. N. Engl J. Med 2006; 354: 1706-1717.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Stone G.W., Maehara A., Lansky A.J. et al. A prospective natural-history study of coronary atherosclerosis. N. Engl J. Med 2011; 364: 226-235.</mixed-citation><mixed-citation xml:lang="en">Stone G.W., Maehara A., Lansky A.J. et al. A prospective natural-history study of coronary atherosclerosis. N. Engl J. Med 2011; 364: 226-235.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mauri L., D. Kereiakes, R. Yeh. et al. Twelve or 12 months of dual antiplatelet therapy after drug-eluting stents. N. Engl J. Med 2014; 371: 2155-2166.</mixed-citation><mixed-citation xml:lang="en">Mauri L., D. Kereiakes, R. Yeh. et al. Twelve or 12 months of dual antiplatelet therapy after drug-eluting stents. N. Engl J. Med 2014; 371: 2155-2166.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bonaca M., Bhatt D.,.Cohen M. et al. Long-term use of ticagrelor in patients with prior myocardial infarction. N. Engl J. Med 2015; 372: 1791-800.</mixed-citation><mixed-citation xml:lang="en">Bonaca M., Bhatt D.,.Cohen M. et al. Long-term use of ticagrelor in patients with prior myocardial infarction. N. Engl J. Med 2015; 372: 1791-800.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Merlini P.A., Bauer K.A., Oltrona L. et al. Persistent activation of coagulation mechanism in unstable angina and myocardial infarction. Circulation 1994; 90: 61-68.</mixed-citation><mixed-citation xml:lang="en">Merlini P.A., Bauer K.A., Oltrona L. et al. Persistent activation of coagulation mechanism in unstable angina and myocardial infarction. Circulation 1994; 90: 61-68.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Panchenko E., Dobrovolsky A., Davletov K. et аl. D-dimer and fibrinolytic system in patients with various degrees of atherosclerosis. Eur Heart J. 1995; 16: 38-42.</mixed-citation><mixed-citation xml:lang="en">Panchenko E., Dobrovolsky A., Davletov K. et аl. D-dimer and fibrinolytic system in patients with various degrees of atherosclerosis. Eur Heart J. 1995; 16: 38-42.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Комаров А.Л., Шахматова О.О., Илющенко Т.А. и др. Факторы, определяющие прогноз у больных со стабильной формой ишемической болезни сердца (по результатам пятилетнего проспективного наблюдения). Кардиология 2012; 1: 4-14</mixed-citation><mixed-citation xml:lang="en">Комаров А.Л., Шахматова О.О., Илющенко Т.А. и др. Факторы, определяющие прогноз у больных со стабильной формой ишемической болезни сердца (по результатам пятилетнего проспективного наблюдения). Кардиология 2012; 1: 4-14</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rothberg M.B., Selestin C., Fiore L.D. et al. Warfarin plus aspirin after MI or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann Intern Med 2005; 143: 241-250.</mixed-citation><mixed-citation xml:lang="en">Rothberg M.B., Selestin C., Fiore L.D. et al. Warfarin plus aspirin after MI or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann Intern Med 2005; 143: 241-250.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen M.L., Sorensen R., Clausen M.T. et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med 2010; 170: 1433-1441.</mixed-citation><mixed-citation xml:lang="en">Hansen M.L., Sorensen R., Clausen M.T. et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med 2010; 170: 1433-1441.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mega J., Braunwald E., Mohanavelu S. et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomized, double-blind, phase II trial. Lancet 2009; 374: 29-38.</mixed-citation><mixed-citation xml:lang="en">Mega J., Braunwald E., Mohanavelu S. et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomized, double-blind, phase II trial. Lancet 2009; 374: 29-38.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Mega J., Braunwald E., Wiviott S.D. et al. Rivaroxaban in patients with a recent acute coronary syndrome. N. Engl J. Med 2012; 366: 9-11.</mixed-citation><mixed-citation xml:lang="en">Mega J., Braunwald E., Wiviott S.D. et al. Rivaroxaban in patients with a recent acute coronary syndrome. N. Engl J. Med 2012; 366: 9-11.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Eikelboom J.W., Connolly S.J., Bosch J. et al. Rivaroxaban with or without aspirin in stable cardiovascular disease. N. Engl J. Med 2017; Aug 27. doi: 10.1056/NEJMoa1709118</mixed-citation><mixed-citation xml:lang="en">Eikelboom J.W., Connolly S.J., Bosch J. et al. Rivaroxaban with or without aspirin in stable cardiovascular disease. N. Engl J. Med 2017; Aug 27. doi: 10.1056/NEJMoa1709118</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
