cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2017.12.10068cardio-72Research ArticleПРАКТИЧЕСКАЯ КАРДИОЛОГИЯ ПРИЛОЖЕНИЕ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ. КЛИНИЧЕСКИЕ СЕМИНАРЫPRACTICAL CARDIOLOGY SUPPLEMENT FOR PRACTISING PHYSICIANS. CLINICAL SEMINARSВариабельность артериального давления в течение суток: прогностическое значение, методы оценки и влияние антигипертензивной терапии24-Hour Arterial Pressure Variability: Prognostic Significance, Methods of Evaluation, Effect of Antihypertensive TherapyОстроумоваО. Д.OstroumovaOlga D.ostroumova.olga@mail.ruБорисоваЕ. В.BorisovaE. V.noemail@neicon.ruОстроумоваТ. М.OstroumovaT. M.noemail@neicon.ruКочетковА. И.KochetkovA. I.noemail@neicon.ruФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РФ; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РФ (Сеченовский Университет)РоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry; I.M. Sechenov First Moscow State Medical UniversityRussian FederationГБУЗ «ГКБ им. Е.О. Мухина» Департамента здравоохранения г. МосквыРоссияCity Clinical Hospital named after E. O. MukhinaRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РФ (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical UniversityRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РФРоссияA.I. Evdokimov Moscow State University of Medicine and DentistryRussian Federation20171711201857126272Copyright © Kardiomag, 20182018KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/72

В статье обсуждаются вопросы прогностической значимости суточной вариабельности артериального давления (АД), ее роли в развитии и прогрессировании поражения различных органов-мишеней при артериальной гипертонии. Представлены данные литературы о влиянии разных режимов антигипертензивной терапии на суточную вариабельность АД. Рассмотрена доказательная база в отношении возможности фиксированной комбинации амлодипин + периндоприл в снижении суточной вариабельности АД.

We discuss in this article problems of prognostic significance of 24-hour arterial pressure variability (24hAPV), as well as the role of 24hAPV in development and progression of various target organs damage by arterial hypertension. We also present literature data on impact of various regimens of antihypertensive therapy on 24hAPV, and on ability of fixed-dose perindopril / amlodipine to lower 24-hAPV.

артериальная гипертониясуточное мониторирование артериального давлениясуточная вариабельность артериального давленияпоражение органов-мишенейантигипертензивная терапияфиксированные комбинации антигипертензивных препаратовпериндоприламлодипинarterial hypertensionambulatory blood pressure monitoringambulatory blood pressure variabilitytarget-organ damageantihypertensive treatmentperindopril/amlodipine fixed-dose combinationReferencesГорбунов В.М. Современные представления о вариабельности артериального давления. Рациональная фармакотерапия в кардиологии 2012; 8 (6): 810-818Горбунов В.М. Современные представления о вариабельности артериального давления. Рациональная фармакотерапия в кардиологии 2012; 8 (6): 810-818Остроумова О.Д. Вариабельность артериального давления и риск развития осложнений при артериальной гипертонии. Терапевтический архив 2012; 10: 91-97Остроумова О.Д. Вариабельность артериального давления и риск развития осложнений при артериальной гипертонии. 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The authors declare that there are no conflicts of interest present.