cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2019.5.2597cardio-656Research ArticleЭКСПЕРИМЕНТАЛЬНАЯ КАРДИОЛОГИЯEXPERIMENTAL CARDIOLOGYСравнительная эффективность эпикардиальной трансплантации прогениторных клеток сердца в виде клеточных пластов и интрамиокардиальных инъекций при стимуляции регенеративных процессов в постинфарктном сердцеEpicardial Transplantation of Cardiac Progenitor Cells Based Cells Sheets is More Promising Method for Stimulation of Myocardial Regeneration, Than Conventional Cell InjectionsДергилевК. В.DergilevK. V.

Dergilev Konstantin V. – MD, PhD, leading researcher

Moscow

doctorkote@gmail.comЦоколаеваЗ. И.TsokolayevaZ. I.БелоглазоваИ. Б.BeloglazovaI. B.РатнерЕ. И.RatnerE. I.ПарфеноваЕ. В.ParfyonovaE. V.ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава РоссииРоссияNational Medical Research Center for CardiologyRussian FederationФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России; ФГБОУ ВО «Московский государственный университет им. М. В. Ломоносова»РоссияNational Medical Research Center for Cardiology; Lomonosov Moscow State UniversityRussian Federation2019250520195955360Copyright © Kardiomag, 20192019KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/656

В настоящее время трансплантация стволовых / прогениторных клеток является перспективным направлением в лечении пациентов с заболеваниями сердца. Терапевтический потенциал трансплантированных клеток напрямую зависит от способа их доставки в миокард, что определяет регенеративные свойства этих клеток и важно для разработки эффективных методов клеточной терапии. В данной работе проведена сравнительная оценка эффективности трансплантации прогениторных клеток сердца (ПКС) в виде интрамиокардиальных инъекций и тканеинженерных конструкций (ТИК), состоящих из сформированных in vitro пластов клеток и наработанного ими внеклеточного матрикса. Показано, что трансплантация ТИК на основе ПКС по сравнению с интрамиокардиальным способом доставки обеспечивает более обширное распределение и сохранение значительно большего числа пролиферирующих клеточных элементов в поврежденном миокарде, замедляет негативное ремодели рование левого желудочка и способствует его васкуляризации.  

Today, transplantation of stem / progenitor cells is a promising approach for the treatment of heart diseases. The therapeutic potential of transplanted cells directly depends on the method of delivery to the myocardium, which determines their regenerative properties. It is important for the development of effective methods of cell therapy. In this paper, we performed a comparative study of efficacy of cardiac progenitor cell (CPC) transplantation by intramyocardial needle injections and by tissue engineering constructs (TEC) – “cell sheets” consisting of cells and their extracellular matrix. It has been shown, that transplantation of TEC in comparison with the intramyocardial delivery provides more extensive distribution and retains more proliferating cellular elements in the damaged myocardium, attenuates the negative cardiac remodeling of the left ventricle and promotes its vascularization.   

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The authors declare that there are no conflicts of interest present.