References

cardio

Кардиология

Kardiologiia

0022-90402412-5660

Kardiomag

10.18087/cardio.2019.2.10231

cardio-510

Research Article

ПРАКТИЧЕСКАЯ КАРДИОЛОГИЯ ПРИЛОЖЕНИЕ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ. КЛИНИЧЕСКИЕ СЕМИНАРЫ

PRACTICAL CARDIOLOGY SUPPLEMENT FOR PRACTISING PHYSICIANS. CLINICAL SEMINARS

Гиполипидемическая терапия при хронической болезни почек: влияние на риск развития сердечно-сосудистых заболеваний и дисфункцию почек

Hypolipidemic Therapy and Chronic Kidney Disease: Effects on Cardiovascular Risks and Renal Dysfunction

Айтбаев

К. А.

Aitbaev

K. A.

Муркамилов

И. Т.

Murkamilov

I. T.

murkamilov.i@mail.ru

Фомин

В. В.

Fomin

V. V.

Moscow.

НИИ молекулярной биологии и медицины при Национальном центре кардиологии и терапии им. акад. М. Миррахимова.КыргызстанResearch Institute of Molecular Biology and Medicine at the National Center of Cardiology and Therapy Named After acad. M. Mirrakhimov.Kyrgyzstan

Кыргызская государственная медицинская академия им. И. К. Ахунбаева; Кыргызско-Российский Славянский университет им. первого Президента России Б. Н. Ельцина.КыргызстанKyrgyz State Medical Academy named after I. K. Akhunbaev; Kyrgyz Russian Slavic University named after the First President of Russia B. N. Yeltsin.Kyrgyzstan

ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России (Сеченовский Университет),РоссияSechenov First Moscow State Medical University (Sechenov University).Russian Federation

2019

08032019

5927987

2019

Kardiomag

https://cardio.elpub.ru/jour/about/submissions#copyrightNotice

https://cardio.elpub.ru/jour/article/view/510

Неуклонный рост распространенности хронической болезни почек (ХБП) представляет собой серьезную проблему общественного здравоохранения, поскольку ХБП потенциально приводит к развитию терминальной стадии почечной недостаточности (ПН), требующей высокозатратной заместительной терапии, и тесно связана с повышенным риском развития сердечно-сосудистых заболеваний (ССЗ), из-за которых умирает большинство пациентов. На прогрессирование дисфункции почек и развитие ССЗ значительное влияние оказывают гипер- и дислипидемии. В настоящем обзоре представлены результаты исследований по оценке влияния гиполипидемической терапии на снижение риска развития ССЗ и замедление дисфункции почек у больных ХБП на преддиализной и диализной стадиях ПН, а также у пациентов с почечным трансплантатом. Кроме того, представлены рекомендации по питанию и новые терапевтические подходы к использованию липидснижающей терапии у больных ХБП, а также перспективы применения новых гиполипидемических препаратов.

Steady increase in the prevalence of chronic kidney disease (CKD) is a serious public health problem, since CKD potentially leads to the development of end-stage renal disease (ESRD) that requires high-cost replacement therapy and is closely associated with increased risk of developing cardiovascular diseases (CVD), which are the cause of death in most patients. Progression of renal dysfunction and development of CVD are significantly affected by hyper- and dyslipidemia. This review contains results of studies evaluating the effect of hypolipidemic therapy on reduction of cardiovascular risk and slowdown of renal dysfunction in patients with CKD at pre-dialysis and dialysis stages of renal failure, as well as in patients with kidney transplant. In addition, recommendations on nutrition and new therapeutic approaches to lipid-lowering therapy in patients with CKD, as well as prospects for the usage of new hypolipidemic drugs are also presented.

хроническая болезнь почексердечно-сосудистые заболеваниягипер- и дислипидемиигиполипидемическая терапиястатины

chronic kidney diseasecardiovascular diseaseshyper- and dyslipidemiahypolipidemic therapystatins

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The authors declare that there are no conflicts of interest present.