cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2020.2.n324cardio-324Research ArticleОБЗОРЫREVIEWSСцинтиграфия миокарда с 123 I-МИБГ в оценке прогноза хронической сердечной недостаточности и эффективности сердечной ресинхронизирующей терапии123 I-MIBG scintigraphy in the assessment of heart failure prognosis and effectiveness of cardiac resynchronization therapyhttps://orcid.org/0000-0002-1513-8614ЗавадовскийК. В.ZavadovskyK. V.

Томск

Тоmsk

Konstz@cardio-tomsk.ruhttps://orcid.org/0000-0001-9453-1635МишкинаА. И.MishkinaA. I.

Мишкина Анна Ивановна, Томск

Mishkina Anna, Тоmsk

anna123.2013@gmail.comhttps://orcid.org/0000-0001-9764-3982ЛебедевД. И.LebedevD. I.

Томск

Тоmsk

titze@mail.ruhttps://orcid.org/0000-0001-5689-9754ГуляМ. О.GulyaM. O.

Томск

Тоmsk

morja20@yandex.ruhttps://orcid.org/0000-0002-0193-9453ВарламоваЮ. В.VarlamovaYu. V.

Томск

Tomsk

jul13@bk.ruhttps://orcid.org/0000-0001-7324-504XЛишмановЮ. Б.LishmanovYu. B.

Томск

Tomsk

zamdir@cardio-tomsk.ruhttps://orcid.org/0000-0002-9050-4493ПоповС. В.PopovS. V.

Томск

Tomsk

psv@cardio-tomsk.ruНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр РАНРоссияCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesRussian Federation202004112019602122130Copyright © Kardiomag, 20202020KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/324

Одним из методов лечения больных хронической сердечной недостаточностью (ХСН) является сердечная ресинхронизирующая терапия (СРТ), которая позволяет снизить смертность в когорте пациентов данного профиля. Сцинтиграфическое исследование симпатической иннервации миокарда позволяет оценить прогноз заболевания и эффективность интервенционного лечения больных ХСН. В основе метода лежит использование радиофармпрепарата 123I-метайодбензилгуанидина (123I-МИБГ), который является структурным аналогом норадреналина и способен избирательно накапливаться в симпатических нервных окончаниях. Данный обзор включает в себя краткое описание метаболизма норадреналина и фармакокинетики 123I-МИБГ в симпатическом нервном окончании, краткое описание методики проведения исследования, а также клиническую значимость данного метода у пациентов с ХСН. Особое внимание уделено возможностям применения данного метода у пациентов с тяжелой ХСН до и после проведения СРТ.

Cardiac resynchronization therapy (CRT) is one of the methods of treating patients with chronic heart failure, which can reduce the mortality rate of this group. Scintigraphic assessment of sympathetic myocardial innervation allows us to evaluate the heart failure prognosis and the effectiveness of interventional treatment. The method is based on use of the radiopharmaceutical 123 I-methiodiobenzylguanidine (123 I-MIBG), which is a structural analogue of norepinephrine and is able to selectively accumulate in the sympathetic nerve endings. This review includes a brief description of norepinephrine metabolism and pharmacokinetics of 123 I-MIBG in the sympathetic nerve ending, a brief description of the study methodology and the clinical significance of this method in patients with heart failure. Particular attention is paid to the possibilities of using this method in patients with severe chronic heart failure before and after CRT.

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The authors declare that there are no conflicts of interest present.