cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2017.9.10022cardio-32Research ArticleПРАКТИЧЕСКАЯ КАРДИОЛОГИЯ ПРИЛОЖЕНИЕ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ КЛИНИЧЕСКИЕ СЕМИНАРЫPRACTICAL CARDIOLOGY SUPPLEMENT FOR PRACTISING PHYSICIANS CLINICAL SEMINARSРоль микро-РНК при АТЕРОГЕНЕЗЕThe Role of MicroRNA in AtherogenesisКучерА. Н.KucherAksana N.aksana.kucher@medgenetics.ruНазаренкоМ. С.NazarenkoM. S.noemail@neicon.ru«НИИ медицинской генетики» «Томского национального исследовательского медицинского центра РАН»; ФГАОУ ВО «Национальный исследовательский Томский государственный университет»Russian Federation«НИИ медицинской генетики» «Томского национального исследовательского медицинского центра РАН»Russian Federation2017171120185796576Copyright © Kardiomag, 20182018KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/32

В настоящем обзоре представлены современные данные о спектре и функциональной значимости микро-РНК, вовлеченных в атерогенез, а также некоторых регуляторных механизмах, обеспечивающих функционирование молекул данного класса. Приводятся примеры использования микро-РНК в качестве диагностических и терапевтических мишеней.

This review provides modern data on the spectrum and the functional significance of micro-RNAs involved in atherogenesis and on some regulatory mechanisms that ensure the functioning of this class of molecules. We also outline some examples of micro-RNAs use as diagnostic and therapeutic targets.

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The authors declare that there are no conflicts of interest present.