cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2025.8.n2920cardio-2920Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCLINICAL CASE REPORTРанняя кальцификация миокарда на фоне фульминантного лимфоцитарно-макрофагального миокардитаEarly Myocardial Calcification on the Background of Fulminant Lymphocytic-Macrophage Myocarditishttps://orcid.org/0000-0002-0015-8620МайринаС. В.MayrinaS. V.

Младший научный сотрудник НИЛ соединительнотканных дисплазий

Junior Researcher at the National Research Institute of Connective Tissue Dysplasia

sonya.spbgmu16@gmail.comhttps://orcid.org/0000-0001-6175-8403МакаровИ. А.MakarovI. A.

врач-патологоанатом патологоанатомического отделения Университетской клиники и ассистент кафедры патологической анатомии с клиникой, к.м.н.

makarov_ia@almazovcentre.ruhttps://orcid.org/0000-0002-7337-0972ЛапшинК. Б.LapshinK. B.

Заведующий отделением интенсивной терапии

 Head, Intensive Care Unit Department

lapshin_kb@almazovcentre.ruАлексееваД. В.AlekseevaD. V.

ассистент кафедры лучевой диагностики и медицинской визуализации, к.м.н.

alekseeva_dv@almazovcentre.ruhttps://orcid.org/0000-0003-0459-4494СеменовА. П.SemyonovA. P.

Заведующий кардиологическим отделением

Head of the Department

semenov_ap@almazovcentre.ruhttps://orcid.org/0000-0002-7817-3847МоисееваО. М.MoiseevaO. M.

Директор Института сердца и сосудов, руководитель и главный научный сотрудник отдела некоронарогенных заболеваний сердца, д.м.н, профессор, заслуженный деятель науки Санкт-Петербурга

Director of the Heart and Vascular Institute, Head and Chief Researcher of the Department of Non-Coronarogenic Heart Diseases, Doctor of Medical Sciences, Professor, Honored Scientist of St. Petersburg

moiseeva.cardio@gmail.comФГБУ «Национальный медицинский исследовательыский центр им. В. А. Алмазова» Минздрава РФ, Санкт-ПетербургРоссияAlmazov National Medical Research Center, St. PetersburgRussian Federation2025100920256588995Copyright © Kardiomag, 20252025KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/2920

Фульминантный миокардит характеризуется крайне тяжелым течением и остается смертельно опасным заболеванием. В литературе описаны единичные случаи диффузной кальцификации миокарда при миокардитах. В связи с этим процесс естественной эволюции структурных изменений в миокарде и их влияние на сердечно-сосудистую систему до сих пор недостаточно изучены. Для анализа выбран клинический случай 37‑летней пациентки с морфологически доказанным фульминантным лимфоцитарным миокардитом и обширной кальцификацией миокарда. Представлены анализ течения заболевания, алгоритм диагностики и выбора метода лечения, а также обзор ранее опубликованных работ.

Fulminant myocarditis is characterized by an extremely severe course and remains a life-threatening disease. Only isolated cases of diffuse myocardial calcification in myocarditis have been reported. For this reason, the process of natural evolution of myocardial structural changes and their impact on the cardiovascular system have not yet been sufficiently studied. A clinical case of a 37-year-old patient with morphologically proven fulminant lymphocytic myocarditis and extensive myocardial calcification was selected for the analysis. This article analyzes the course of the disease, an algorithm for diagnosis and selection of a treatment method, and provides a review of previously published studies.

Фульминантный миокардиткальциноз миокардаиммуносупрессивная терапияFulminant myocarditismyocardial calcinosisimmunosuppressive therapyФинансирование Исследование выполнено в рамках Государственного задания Министерства здравоохранения Российской Федерации «Изучение патогенеза миокардитов и перикардитов с позиции аутовоспаления и аутоиммунитета» № 25 25 00337. Конфликт интересов Все авторы заявляют об отсутствии потенциального конфликта интересов, требующего раскрытия в данной статье.The study was performed as part of the State Assignment of the Ministry of Health of the Russian Federation “Study of the pathogenesis of myocarditis and pericarditis from the standpoint of autoinflammation and autoimmunity” # 25 25 00337. Conflict of interest All authors declare no potential conflict of interest that would require disclosure in the present article.ReferencesAmmirati E, Cipriani M, Lilliu M, Sormani P, Varrenti M, Raineri C et al. 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The authors declare that there are no conflicts of interest present.