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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardio</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиология</journal-title><trans-title-group xml:lang="en"><trans-title>Kardiologiia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0022-9040</issn><issn pub-type="epub">2412-5660</issn><publisher><publisher-name>Kardiomag</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18087/cardio.2523</article-id><article-id custom-type="elpub" pub-id-type="custom">cardio-261</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Проблема тромбоза у пациентов со злокачественными заболеваниями</article-title><trans-title-group xml:lang="en"><trans-title>Thrombosis in patients with malignancy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плохова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Plokhova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дундуа</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Dundua</surname><given-names>D. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий ФМБА России»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Clinical Center FMBA of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>18</day><month>11</month><year>2018</year></pub-date><volume>58</volume><issue>9S</issue><fpage>19</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kardiomag, 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Kardiomag</copyright-holder><copyright-holder xml:lang="en">Kardiomag</copyright-holder><license xlink:href="https://cardio.elpub.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://cardio.elpub.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://cardio.elpub.ru/jour/article/view/261">https://cardio.elpub.ru/jour/article/view/261</self-uri><abstract><p>На протяжении десятилетий тромбоз рассматривался как осложнение ССЗ, однако данная проблема долгое время редко принималась во внимание при наличии рака. Хотя связь между онкологическим заболеванием и тромбозом была признана почти 150 лет назад, только недавно сложилось мнение, что рак является протромботическим заболеванием. Тромбоз для многих пациентов становится одним из первых и ранних симптомов рака и в то же время считается частой причиной смерти у онкобольных. Тромботические события оказывают значимое влияние на качество жизни пациентов, ухудшают краткосрочный и долгосрочный прогнозы. Последние исследования показали рост частоты тромбоза, ассоциированного с раком. Цель данного обзора - обобщить современные взгляды на патофизиологию, а также изложить новые подходы к оценке риска, профилактике и лечению тромбоза при онкологических заболеваниях.</p></abstract><trans-abstract xml:lang="en"><p>Thrombosis traditionally considered as a complication of cardiovascular disease, however, this problem until recently was rarely taken into account in the presence of cancer. Although the association between cancer and thrombosis has been known almost 150 years ago, awareness of the impact of thrombotic complications have increased only now. Cancer is an independent major risk factor for venous thromboembolism (VTE), which is the leading cause of death of cancer patient. The incidence ofVTE is steadily increasing in these patients. Thrombotic events have a significant impact on the quality of life of patients, and are associated with worsening of their short-term and long-term survival. The objective of this review is to summarize modern views on pathophysiology, as well as to outline new approaches to risk assessment, prevention and treatment of thrombosis in cancer patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тромбоз</kwd><kwd>тромбоэмболия</kwd><kwd>рак</kwd><kwd>кардиоонкология</kwd><kwd>thrombosis</kwd><kwd>thromboembolism</kwd><kwd>cancer</kwd><kwd>сardioangiology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Piccioli A, Prandoni P. Idiopathic venous thromboembolism as a first manifestation of cancer. Haemostasis. 2001;31 Suppl 1:37-9. PMID:11990473</mixed-citation><mixed-citation xml:lang="en">Piccioli A, Prandoni P. Idiopathic venous thromboembolism as a first manifestation of cancer. Haemostasis. 2001;31 Suppl 1:37-9. 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