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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardio</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиология</journal-title><trans-title-group xml:lang="en"><trans-title>Kardiologiia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0022-9040</issn><issn pub-type="epub">2412-5660</issn><publisher><publisher-name>Kardiomag</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18087/cardio.2565</article-id><article-id custom-type="elpub" pub-id-type="custom">cardio-259</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Сосудистые нарушения на фоне полихимиотерапии онкологических заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>Vascular Complications of Cancer Chemotherapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беленков</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Belenkov</surname><given-names>Yu. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Привалова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Privalova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кожевникова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozhevnikova</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кириченко</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirichenko</surname><given-names>Y. Y.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый МГМУ имени И. М. Сеченова» Минздрава РФ (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>18</day><month>11</month><year>2018</year></pub-date><volume>58</volume><issue>9S</issue><fpage>4</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kardiomag, 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Kardiomag</copyright-holder><copyright-holder xml:lang="en">Kardiomag</copyright-holder><license xlink:href="https://cardio.elpub.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://cardio.elpub.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://cardio.elpub.ru/jour/article/view/259">https://cardio.elpub.ru/jour/article/view/259</self-uri><abstract><p>Развитие и применение новых противоопухолевых препаратов привело к повышению выживаемости онкологических пациентов на 5 лет и более. Однако применение многих современных химиопрепаратов связано с развитием сердечно-сосудистой токсичности, что повышает риск возникновения таких заболеваний, как артериальная гипертензия, СН, тромбозы и тромбоэмболии, кардиомиопатии и аритмии. Эти побочные эффекты могут ограничивать возможности противоопухолевого лечения и снижать дальнейшие перспективы благоприятного исхода. В связи с широкой распространенностью использования современных химиопрепаратов и увеличением продолжительности жизни пациентов с онкологическими заболеваниями заболеваемость сердечно-сосудистой патологией будет продолжать расти. Соответственно необходима тщательная оценка и управление ФР развития ССЗ у онкологических больных с помощью кардиологов и онкологов, работающих вместе.</p></abstract><trans-abstract xml:lang="en"><p>Development and use of new anticancer drugs has resulted in the improving of 5-year survival rates in patients with cancer. However, many of the modern chemotherapies are associated with cardiovascular toxicities that increases cardiovascular risk in cancer patients, including hypertension, heart failure, thrombosis and thromboembolism, cardiomyopathy, and arrhythmias. These side effects limitation restrict treatment options and farther perspectives. With increasing use of modern chemotherapies and prolongation of the cancer patients survival, the incidence of cardiovascular disease in this patient population will continue to increase. Accordingly, careful assessment and management of cardiovascular risk factors in cancer patients by oncologists and cardiologists working together is essential for optimal care.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиоонкология</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>осложнения химиотерапии</kwd><kwd>дисфункция эндотелия</kwd><kwd>сardioangiology</kwd><kwd>cardiovascular diseases</kwd><kwd>complications of cancer chemotherapy</kwd><kwd>dysfunction of endothelium</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M. et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012: Globocan 2012. International Journal of Cancer. 2015,136 (5):E359-86. DOI:10.1002/ijc. 29210</mixed-citation><mixed-citation xml:lang="en">Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M. et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012: Globocan 2012. International Journal of Cancer. 2015,136 (5):E359-86. DOI:10.1002/ijc. 29210</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Truong J., Yan AT, Cramarossa G., Chan KKW. Chemotherapy-induced cardiotoxicity: detection, prevention, and management. Can J. Cardiol. 2014,30 (8):869-78. DOI:10.1016/j. cjca. 2014.04.029</mixed-citation><mixed-citation xml:lang="en">Truong J., Yan AT, Cramarossa G., Chan KKW. Chemotherapy-induced cardiotoxicity: detection, prevention, and management. Can J. Cardiol. 2014,30 (8):869-78. DOI:10.1016/j. cjca. 2014.04.029</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ewer MS, Ewer S.M. Cardiotoxicity of anticancer treatments: what the cardiologist needs to know. Nature Reviews Cardiology. 2010,7 (10):564-75. DOI:10.1038/nrcardio. 2010.121</mixed-citation><mixed-citation xml:lang="en">Ewer MS, Ewer S.M. Cardiotoxicity of anticancer treatments: what the cardiologist needs to know. Nature Reviews Cardiology. 2010,7 (10):564-75. DOI:10.1038/nrcardio. 2010.121</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Suter TM, Ewer M.S. Cancer drugs and the heart: importance and management. European Heart Journal. 2013,'34 ( 15): 1102-11. D. OI: 10.1093/ eurheart j / ehs 181</mixed-citation><mixed-citation xml:lang="en">Suter TM, Ewer M.S. Cancer drugs and the heart: importance and management. European Heart Journal. 2013,'34 ( 15): 1102-11. D. OI: 10.1093/ eurheart j / ehs 181</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bovelli D., Plataniotis G., Roila F., ESMO Guidelines Working Group. Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO Clinical Practice Guidelines. Ann Oncol. 2010,21 Suppl 5: v277-282. DOI:10.1093/annonc/mdq200</mixed-citation><mixed-citation xml:lang="en">Bovelli D., Plataniotis G., Roila F., ESMO Guidelines Working Group. Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO Clinical Practice Guidelines. Ann Oncol. 2010,21 Suppl 5: v277-282. DOI:10.1093/annonc/mdq200</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Aleman BMP, van den Belt-Dusebout AW, De Bruin ML, van't Veer MB, Baaijens MHA, Boer JP d. et al. Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood. 2007,109 (5):1878-86. DOI:10.1182/blo od-2006-07-034405</mixed-citation><mixed-citation xml:lang="en">Aleman BMP, van den Belt-Dusebout AW, De Bruin ML, van't Veer MB, Baaijens MHA, Boer JP d. et al. Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood. 2007,109 (5):1878-86. DOI:10.1182/blo od-2006-07-034405</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Емелина Е. И., Гендлин Г. Е., Сторожаков Г. И., Лепков С. В., Демина Е. А. Динамика показателей ЭхоКГ у больных лимфопролиферативными заболеваниями, получавших антрациклиновые препараты. Российский Медицинский Журнал. 2007, ( 1) :7-11.</mixed-citation><mixed-citation xml:lang="en">Емелина Е. И., Гендлин Г. Е., Сторожаков Г. И., Лепков С. В., Демина Е. А. Динамика показателей ЭхоКГ у больных лимфопролиферативными заболеваниями, получавших антрациклиновые препараты. Российский Медицинский Журнал. 2007, ( 1) :7-11.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Казюлин А. Н., Вельшер Л. З., Королева И. А., Кучерявый Ю. А. К ардиотоксичность при проведении химиотерапии онкологических заболеваний. Медицина критических состояний. 2010,1 (1):62-70.</mixed-citation><mixed-citation xml:lang="en">Казюлин А. Н., Вельшер Л. З., Королева И. А., Кучерявый Ю. А. К ардиотоксичность при проведении химиотерапии онкологических заболеваний. Медицина критических состояний. 2010,1 (1):62-70.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Daher IN, Yeh E.T. Vascular complications of selected cancer therapies. Nature Clinical Practice Cardiovascular Medicine. 2008,5 (12):797-805. DOI:10.1038/ncpcardio1375</mixed-citation><mixed-citation xml:lang="en">Daher IN, Yeh E.T. Vascular complications of selected cancer therapies. Nature Clinical Practice Cardiovascular Medicine. 2008,5 (12):797-805. DOI:10.1038/ncpcardio1375</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Epstein FH, Vane JR, Anggard EE, Botting RM. Regulatory Functions of the Vascular Endothelium. New England Journal of Medicine. 1990,323 ( 1) :27-36. DOI: 10.1056/NEJM199007053230106</mixed-citation><mixed-citation xml:lang="en">Epstein FH, Vane JR, Anggard EE, Botting RM. Regulatory Functions of the Vascular Endothelium. New England Journal of Medicine. 1990,323 ( 1) :27-36. DOI: 10.1056/NEJM199007053230106</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Soultati A., Mountzios G., Avgerinou C., Papaxoinis G., Pectasides D., Dimopoulos M-A et al. Endothelial vascular toxicity from chemotherapeu tic agents: Preclinical evidence and clinical implications. Cancer Treatment Reviews. 2012,38 (5):473-83. DOI:10.1016/j. ctrv. 2011.09.002</mixed-citation><mixed-citation xml:lang="en">Soultati A., Mountzios G., Avgerinou C., Papaxoinis G., Pectasides D., Dimopoulos M-A et al. Endothelial vascular toxicity from chemotherapeu tic agents: Preclinical evidence and clinical implications. Cancer Treatment Reviews. 2012,38 (5):473-83. DOI:10.1016/j. ctrv. 2011.09.002</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kohli S., Kohli M. Acute Chemotherapy-Induced Cardiovascular Changes in Patients With Testicular Cancer: Are There Implications for Blood Pressure Management in Patients Receiving Chemotherapy? Journal of Clinical Oncology. 2006,24 (15):2399-2399. DOI:10.1200/JCO. 2006.05.7836</mixed-citation><mixed-citation xml:lang="en">Kohli S., Kohli M. Acute Chemotherapy-Induced Cardiovascular Changes in Patients With Testicular Cancer: Are There Implications for Blood Pressure Management in Patients Receiving Chemotherapy? Journal of Clinical Oncology. 2006,24 (15):2399-2399. DOI:10.1200/JCO. 2006.05.7836</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Meinardi MT, Gietema JA, van der Graaf WTA, van Veldhuisen DJ, Runne MA, Sluiter WJ et al. Cardiovascular Morbidity in Long-Term Survivors of Metastatic Testicular Cancer. Journal of Clinical Oncology. 2000,18 (8):1725-32. DOI:10.1200/JCO. 2000.18.8.1725</mixed-citation><mixed-citation xml:lang="en">Meinardi MT, Gietema JA, van der Graaf WTA, van Veldhuisen DJ, Runne MA, Sluiter WJ et al. Cardiovascular Morbidity in Long-Term Survivors of Metastatic Testicular Cancer. Journal of Clinical Oncology. 2000,18 (8):1725-32. DOI:10.1200/JCO. 2000.18.8.1725</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sagstuen H., Aass N., Fossa SD, Dahl O., Klepp O., Wist EA et al. Blood Pressure and Body Mass Index in Long-Term Survivors of Testicular Cancer. Journal of Clinical Oncology. 2005,23 (22):4980-90. DOI:10.1200/JCO. 2005.06.882</mixed-citation><mixed-citation xml:lang="en">Sagstuen H., Aass N., Fossa SD, Dahl O., Klepp O., Wist EA et al. Blood Pressure and Body Mass Index in Long-Term Survivors of Testicular Cancer. Journal of Clinical Oncology. 2005,23 (22):4980-90. DOI:10.1200/JCO. 2005.06.882</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">de Vos FYFL, Nuver J., Willemse PHB, van der Zee AGJ, Messerschmidt J., Burgerhof JGM et al. Long-term survivors of ovarian malignancies after cisplatin-based chemotherapy. European Journal of Cancer. 2004,40 (5):696-700. DOI:10.1016/j. ejca. 2003.11.026</mixed-citation><mixed-citation xml:lang="en">de Vos FYFL, Nuver J., Willemse PHB, van der Zee AGJ, Messerschmidt J., Burgerhof JGM et al. Long-term survivors of ovarian malignancies after cisplatin-based chemotherapy. European Journal of Cancer. 2004,40 (5):696-700. DOI:10.1016/j. ejca. 2003.11.026</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gietema JA, Sleijfer DT, Willemse PH, Schraffordt Koops H., van Ittersum E., Verschuren WM et al. Long-term follow-up of cardiovascular risk factors in patients given chemotherapy for disseminated nonseminomatous testicular cancer. Ann Intern Med. 1992,116 (9):709-15. PMID:1558341</mixed-citation><mixed-citation xml:lang="en">Gietema JA, Sleijfer DT, Willemse PH, Schraffordt Koops H., van Ittersum E., Verschuren WM et al. Long-term follow-up of cardiovascular risk factors in patients given chemotherapy for disseminated nonseminomatous testicular cancer. Ann Intern Med. 1992,116 (9):709-15. PMID:1558341</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Strumberg D., Brügge S., Korn MW, Koeppen S., Ranft J., Scheiber G. et al. Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer. Annals of Oncology. 2002,13 (2):229-36. DOI:10.1093/annonc/mdf058</mixed-citation><mixed-citation xml:lang="en">Strumberg D., Brügge S., Korn MW, Koeppen S., Ranft J., Scheiber G. et al. Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer. Annals of Oncology. 2002,13 (2):229-36. DOI:10.1093/annonc/mdf058</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Weijl NI, Rutten MFJ, Zwinderman AH, Keizer HJ, Nooy MA, Rosendaal FR et al. Thromboembolic Events During Chemotherapy for Germ Cell Cancer: A Cohort Study and Review of the Literature. Journal of Clinical Oncology. 2000,18 (10):2169-78. DOI:10.1200/JCO. 2000.18.10.2169</mixed-citation><mixed-citation xml:lang="en">Weijl NI, Rutten MFJ, Zwinderman AH, Keizer HJ, Nooy MA, Rosendaal FR et al. Thromboembolic Events During Chemotherapy for Germ Cell Cancer: A Cohort Study and Review of the Literature. Journal of Clinical Oncology. 2000,18 (10):2169-78. DOI:10.1200/JCO. 2000.18.10.2169</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Meinardi MT, Gietema JA, van Veldhuisen DJ, van der Graaf WTA, de Vries EGE, Sleijfer D.T. Long-term chemotherapy-related cardiovascular morbidity. Cancer Treatment Reviews. 2000,26 (6):429-47. DOI:10.1053 /ctrv. 2000.0175</mixed-citation><mixed-citation xml:lang="en">Meinardi MT, Gietema JA, van Veldhuisen DJ, van der Graaf WTA, de Vries EGE, Sleijfer D.T. Long-term chemotherapy-related cardiovascular morbidity. Cancer Treatment Reviews. 2000,26 (6):429-47. DOI:10.1053 /ctrv. 2000.0175</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Role of Vascular Congestion in Cisplatin-Induced Acute Renal Failure in the Rat. Nephrology Dialysis Transplantation [Internet]. 1992 [cited 2018], DOI:10.1093/oxfordjournals. ndt. a091984</mixed-citation><mixed-citation xml:lang="en">Role of Vascular Congestion in Cisplatin-Induced Acute Renal Failure in the Rat. Nephrology Dialysis Transplantation [Internet]. 1992 [cited 2018], DOI:10.1093/oxfordjournals. ndt. a091984</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">de Haas EC, Altena R., Boezen HM, Zwart N., Smit AJ, Bakker SJL et al. Early development of the metabolic syndrome after chemotherapy for testicular cancer. Annals ofOncology. 2013,24 (3):749-55. DOI:10.1093/annonc/mds527</mixed-citation><mixed-citation xml:lang="en">de Haas EC, Altena R., Boezen HM, Zwart N., Smit AJ, Bakker SJL et al. Early development of the metabolic syndrome after chemotherapy for testicular cancer. Annals ofOncology. 2013,24 (3):749-55. DOI:10.1093/annonc/mds527</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fung C., Fossa SD, Milano MT, Sahasrabudhe DM, Peterson DR, Travis L.B. Cardiovascular Disease MortalityAfter Chemotherapy or Surgery for Testicular Nonseminoma: A Population-Based Study. Journal of Clinical Oncology. 2015,33 (28):3105-15. DOI:10.1200/JCO. 2014.60.3654</mixed-citation><mixed-citation xml:lang="en">Fung C., Fossa SD, Milano MT, Sahasrabudhe DM, Peterson DR, Travis L.B. Cardiovascular Disease MortalityAfter Chemotherapy or Surgery for Testicular Nonseminoma: A Population-Based Study. Journal of Clinical Oncology. 2015,33 (28):3105-15. DOI:10.1200/JCO. 2014.60.3654</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lajer H., Daugaard G. Cisplatin and hypomagnesemia. Cancer Treatment Reviews. 1999,25 (1):47-58. DOI:10.1053/ctrv. 1999.0097</mixed-citation><mixed-citation xml:lang="en">Lajer H., Daugaard G. Cisplatin and hypomagnesemia. Cancer Treatment Reviews. 1999,25 (1):47-58. DOI:10.1053/ctrv. 1999.0097</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">El-Awady E-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. EuropeanJournal of Pharmacology. 2011,650 (1):335-41. DOI:10.1016/j. ejphar. 2010.09.085</mixed-citation><mixed-citation xml:lang="en">El-Awady E-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. EuropeanJournal of Pharmacology. 2011,650 (1):335-41. DOI:10.1016/j. ejphar. 2010.09.085</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Rabik CA, Dolan M.E. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treatment Reviews. 2007,33 (1):9-23. DOI:10.1016/j. ctrv. 2006.09.006</mixed-citation><mixed-citation xml:lang="en">Rabik CA, Dolan M.E. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treatment Reviews. 2007,33 (1):9-23. DOI:10.1016/j. ctrv. 2006.09.006</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Yao X., Panichpisal K., Kurtzman N., Nugent K. Cisplatin Nephrotoxicity: A Review. The American Journal of the Medical Sciences. 2007,334 (2):115-24. DOI:10.1097/MAJ. 0b013e31812dfe1e</mixed-citation><mixed-citation xml:lang="en">Yao X., Panichpisal K., Kurtzman N., Nugent K. Cisplatin Nephrotoxicity: A Review. The American Journal of the Medical Sciences. 2007,334 (2):115-24. DOI:10.1097/MAJ. 0b013e31812dfe1e</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Miller RP, Tadagavadi RK, Ramesh G., Reeves W.B. Mechanisms of Cisplatin Nephrotoxicity. Toxins. 2010,2 (11):2490-518. DOI:10.3390/tox-ins2112490</mixed-citation><mixed-citation xml:lang="en">Miller RP, Tadagavadi RK, Ramesh G., Reeves W.B. Mechanisms of Cisplatin Nephrotoxicity. Toxins. 2010,2 (11):2490-518. DOI:10.3390/tox-ins2112490</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pabla N., Dong Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney International. 2008,-73 (9):994-1007. DOI:10.1038/sj. ki. 5002786</mixed-citation><mixed-citation xml:lang="en">Pabla N., Dong Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney International. 2008,-73 (9):994-1007. DOI:10.1038/sj. ki. 5002786</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Nuver J., Smit AJ, Sleijfer DT, van Gessel AI, van Roon AM, van der Meer J. et al. Microalbuminuria, decreased fibrinolysis, and inflammation as early signs of atherosclerosis in long-term survivors of disseminated testicular cancer. EuropeanJournal ofCancer. 2004,40 (5):701-6. DOI:10.1016/j. ejca. 2003.12.012</mixed-citation><mixed-citation xml:lang="en">Nuver J., Smit AJ, Sleijfer DT, van Gessel AI, van Roon AM, van der Meer J. et al. Microalbuminuria, decreased fibrinolysis, and inflammation as early signs of atherosclerosis in long-term survivors of disseminated testicular cancer. EuropeanJournal ofCancer. 2004,40 (5):701-6. DOI:10.1016/j. ejca. 2003.12.012</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Brana I., Tabernero J. Cardiotoxicity. Annals of Oncology. 2010,21 (Supplement 7):vii173-9. DOI:10.1093/annonc/mdq295</mixed-citation><mixed-citation xml:lang="en">Brana I., Tabernero J. Cardiotoxicity. Annals of Oncology. 2010,21 (Supplement 7):vii173-9. DOI:10.1093/annonc/mdq295</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart T., Pavlakis N., Ward M. Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina: Fluoropyrimidine cardiotoxicity. Internal Medicine Journal. 2010,40 (4):303-7. DOI:10.1111/j. 1445-5994.2009.02144. x</mixed-citation><mixed-citation xml:lang="en">Stewart T., Pavlakis N., Ward M. Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina: Fluoropyrimidine cardiotoxicity. Internal Medicine Journal. 2010,40 (4):303-7. DOI:10.1111/j. 1445-5994.2009.02144. x</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Cwikiel M., Eskilsson J., Albertsson M., Stavenow L. The influence of 5-fluorouracil and methotrexate on vascular endothelium. An experimental study using endothelial cells in the culture. Annals of Oncology. 1996,7 (7):731-7. DOI:10.1093/oxfordjournals. annonc. a010723</mixed-citation><mixed-citation xml:lang="en">Cwikiel M., Eskilsson J., Albertsson M., Stavenow L. The influence of 5-fluorouracil and methotrexate on vascular endothelium. An experimental study using endothelial cells in the culture. Annals of Oncology. 1996,7 (7):731-7. DOI:10.1093/oxfordjournals. annonc. a010723</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Alter P., Herzum M., Soufi M., Schaefer J., Maisch B. Cardiotoxicity of 5-Fluorouracil. Cardiovascular &amp; Hematological Agents in Medicinal Chemistry. 2006,4 (1):1-5. DOI:10.2174/187152506775268785</mixed-citation><mixed-citation xml:lang="en">Alter P., Herzum M., Soufi M., Schaefer J., Maisch B. Cardiotoxicity of 5-Fluorouracil. Cardiovascular &amp; Hematological Agents in Medicinal Chemistry. 2006,4 (1):1-5. DOI:10.2174/187152506775268785</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Wakabayashi I., Groschner K. Vascular Actions of Anthracycline Antibiotics. Current Medicinal Chemistry. 2003,10 (5):427-36. DOI:10.2174/0929867033368259</mixed-citation><mixed-citation xml:lang="en">Wakabayashi I., Groschner K. Vascular Actions of Anthracycline Antibiotics. Current Medicinal Chemistry. 2003,10 (5):427-36. DOI:10.2174/0929867033368259</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Vejpongsa P., Yeh ETH. Prevention of Anthracycline-Induced Cardiotoxicity. Journal of the American College of Cardiology. 2014,64 (9):938-45. DOI:10.1016/j. jacc. 2014.06.1167</mixed-citation><mixed-citation xml:lang="en">Vejpongsa P., Yeh ETH. Prevention of Anthracycline-Induced Cardiotoxicity. Journal of the American College of Cardiology. 2014,64 (9):938-45. DOI:10.1016/j. jacc. 2014.06.1167</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Новаковская С. А., Арчакова Л. И. Ультраструктурная реорганизация сосудов микроциркуляторного русла миокарда при различных формах антрациклиновой кардиомиопатии. Материалы IX Международной научно-практической конференции «Дисфункция эндотелия: экспериментальные и клинические исследования», Витебск, 27 мая 2016 г [Internet]. -Витебск: ВГМУ, 2016. p. 46-8.</mixed-citation><mixed-citation xml:lang="en">Новаковская С. А., Арчакова Л. И. Ультраструктурная реорганизация сосудов микроциркуляторного русла миокарда при различных формах антрациклиновой кардиомиопатии. Материалы IX Международной научно-практической конференции «Дисфункция эндотелия: экспериментальные и клинические исследования», Витебск, 27 мая 2016 г [Internet]. -Витебск: ВГМУ, 2016. p. 46-8.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Avelar E., Truong QA, Inyangetor D., Marfatia R., Yang C., Kaloudis E. et al. Effect of Adjuvant Chemotherapy on Left Ventricular Remodeling in Women with Newly Diagnosed Primary Breast Cancer: A Pilot Prospective Longitudinal Cardiac Magnetic Resonance Imaging Study. Journal of Thoracic Imaging. 2017,32 (6):365-9. DOI:10.1097/RTI. 0000000000000285</mixed-citation><mixed-citation xml:lang="en">Avelar E., Truong QA, Inyangetor D., Marfatia R., Yang C., Kaloudis E. et al. Effect of Adjuvant Chemotherapy on Left Ventricular Remodeling in Women with Newly Diagnosed Primary Breast Cancer: A Pilot Prospective Longitudinal Cardiac Magnetic Resonance Imaging Study. Journal of Thoracic Imaging. 2017,32 (6):365-9. DOI:10.1097/RTI. 0000000000000285</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
