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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardio</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиология</journal-title><trans-title-group xml:lang="en"><trans-title>Kardiologiia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0022-9040</issn><issn pub-type="epub">2412-5660</issn><publisher><publisher-name>Kardiomag</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18087/cardio.2022.8.n2147</article-id><article-id custom-type="elpub" pub-id-type="custom">cardio-2147</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH ARTICLES</subject></subj-group></article-categories><title-group><article-title>Оценка функции правого желудочка при акромегалии: сравнение активной стадии заболевания и ремиссии</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of right ventricular functions in acromegaly: comparison of active disease with remission</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирхан</surname><given-names>Осман</given-names></name><name name-style="western" xml:lang="en"><surname>Pirhan</surname><given-names>Osman</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение кардиологии, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Cardiology, Istanbul, Turkey</p></bio><email xlink:type="simple">opirhan@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эртугрул</surname><given-names>Абдулселил Саит</given-names></name><name name-style="western" xml:lang="en"><surname>Ertuğrul</surname><given-names>Abdülcelil Sait</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение кардиологии, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Cardiology, Istanbul, Turkey</p></bio><email xlink:type="simple">drsaitertugrul@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Йылдыз</surname><given-names>Дженнет</given-names></name><name name-style="western" xml:lang="en"><surname>Yıldız</surname><given-names>Cennet</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение кардиологии, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Cardiology, Istanbul, Turkey</p></bio><email xlink:type="simple">cennet_yildiz@live.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карабулут</surname><given-names>Дилай</given-names></name><name name-style="western" xml:lang="en"><surname>Karabulut</surname><given-names>Dilay</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение кардиологии, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Cardiology, Istanbul, Turkey</p></bio><email xlink:type="simple">dilay_karakozak@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пехливан</surname><given-names>Бахар</given-names></name><name name-style="western" xml:lang="en"><surname>Pehlivan</surname><given-names>Bahar</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение эндокринологии и обмена веществ, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Endocrinology and Metabolism, Istanbul, Turkey</p></bio><email xlink:type="simple">h_karagoz@hotmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пискинпаса</surname><given-names>Хамид</given-names></name><name name-style="western" xml:lang="en"><surname>Piskinpasa</surname><given-names>Hamide</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение эндокринологии и обмена веществ, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Endocrinology and Metabolism, Istanbul, Turkey</p></bio><email xlink:type="simple">sdogansen@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Догансен</surname><given-names>Сема Чифтджи</given-names></name><name name-style="western" xml:lang="en"><surname>Dogansen</surname><given-names>Sema Ciftci</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение эндокринологии и обмена веществ, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Endocrinology and Metabolism, Istanbul, Turkey</p></bio><email xlink:type="simple">meralmert@hotmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мерт</surname><given-names>Мерал</given-names></name><name name-style="western" xml:lang="en"><surname>Mert</surname><given-names>Meral</given-names></name></name-alternatives><bio xml:lang="ru"><p>MD</p><p>Отделение эндокринологии и обмена веществ, Стамбул, Турция</p></bio><bio xml:lang="en"><p>MD</p><p>Department of Endocrinology and Metabolism, Istanbul, Turkey</p></bio><email xlink:type="simple">meralmert@hotmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Учебно-исследовательский госпиталь доктора Сади Конук в Бакыркой, Университет медицинских наук</institution><country>Турция</country></aff><aff xml:lang="en"><institution>Bakırköy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences</institution><country>Turkey</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Учебно-исследовательский госпиталь доктора Сади Конук Бакыркой</institution><country>Турция</country></aff><aff xml:lang="en"><institution>Bakirkoy Dr. Sadi Konuk Training and Research Hospital</institution><country>Turkey</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>08</month><year>2022</year></pub-date><volume>62</volume><issue>8</issue><fpage>52</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kardiomag, 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Kardiomag</copyright-holder><copyright-holder xml:lang="en">Kardiomag</copyright-holder><license xlink:href="https://cardio.elpub.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://cardio.elpub.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://cardio.elpub.ru/jour/article/view/2147">https://cardio.elpub.ru/jour/article/view/2147</self-uri><abstract><p>Цель    Поражение сердца при акромегалии определяется как акромегалическая кардиомиопатия, представляющее собой опасное хроническое заболевание. Предыдущие исследования акромегалической кардиомиопатии преимущественно были сосредоточены на морфологической и функциональной оценке левых отделов сердца. Поскольку литературные данные о функции правых отделов сердца у больных акромегалией ограничены, мы стремились оценить структуру и функцию правых отделов сердца у таких пациентов.Материал и методы    В исследование было включено 43 взрослых пациента с акромегалией и 42 человека - в качестве контрольной группы. Всем больным проводилось эхокардиографическое исследование. Результаты сравнивали между группами с акромегалией и контрольной группой, а также между группами с активной стадией заболевания и контролируемой акромегалией.Результаты    В группе акромегалии были увеличены толщина межжелудочковой перегородки, толщина свободной стенки правого желудочка (ПЖ), малый диаметр правого предсердия (ПП), базальный и продольный диаметры ПЖ, конечно-диастолическая и конечно-систолическая площади ПЖ, отношение E/E', время изоволюметрического расслабления и время выброса ПЖ. Соотношение E/A и скорость E' были снижены. Гормон роста (GH) и инсулиноподобный фактор роста 1 (IGF-1) положительно коррелировали с продольным размером ПЖ, индексированным размером по короткой оси правого желудочка и индексированной конечно-диастолической площадью ПЖ. Пациенты с активной акромегалией имели повышенный индекс работоспособности миокарда ПЖ (RVIMP) и время изоволюметрического сокращения, а также укороченное время изгнания ПЖ по сравнению с пациентами в стадии ремиссии. Значение RVIMP 0,435 прогнозировало активную стадию акромегалии с чувствительностью и специфичностью 0,83 и 0,64 соответственно (р=0,002).Выводы    Увеличение размеров правых отделов сердца вместе с толщиной свободной стенки ПЖ может быть связано с акромегалической кардиомиопатией. RVIMP, время изоволюметрического сокращения и время изгнания являются параметрами, которые могут использоваться для оценки активной стадии акромегалии.</p></abstract><trans-abstract xml:lang="en"><p>Aim    Cardiac involvement in acromegaly is defined as acromegalic cardiomyopathy, an insidious and chronic disease. Previous research on acromegalic cardiomyopathy was largely focused on morphological and functional assessment of the left heart. Since the literature data regarding right heart function in acromegalic patients are limited, we aimed to evaluate the structure and function of the right heart in such patients.Material and Methods    We included 43 adult participants as the acromegaly group and 42 individuals as the control group. All patients underwent echocardiographic evaluation. The results were compared between acromegaly and control groups and between active and controlled acromegaly groups.Results    The acromegaly group had increased interventricular septum thickness, right ventricular (RV) free wall thickness, right atrium (RA) minor diameter, RV basal and longitudinal diameters, RV end-diastolic and end-systolic areas, E / E’ ratio, isovolumetric relaxation time, and RV ejection time. The E / A ratio and E’ velocity were reduced. GH and IGF-1 were positively correlated with RV longitudinal diameter, indexed RA minor-axis dimension, and indexed RV end-diastolic area. Patients with active acromegaly had increased RV index of myocardial performance (RVIMP) and isovolumetric contraction time and shortened RV ejection time compared to patients in remission. A RVIMP value of 0.435 predicted active acromegaly with a sensitivity and specificity of 0.83 and 0.64, respectively (p=0.002).Conclusions    Increases in the size and diameters of the right heart chambers along with RV free wall thickness may be attributed to acromegalic cardiomyopathy. RVIMP, isovolumetric contraction time, and ejection time are parameters that can be used in the evaluation of active acromegaly disease.</p><p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>Acromegaly</kwd><kwd>right heart</kwd><kwd>function</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Конфликт интересов не заявлен</funding-statement><funding-statement xml:lang="en">No conflict of interest is reported.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lavrentaki A, Paluzzi A, Wass JAH, Karavitaki N. Epidemiology of acromegaly: review of population studies. Pituitary. 2017;20(1):4–9. DOI: 10.1007/s11102-016-0754-x</mixed-citation><mixed-citation xml:lang="en">Lavrentaki A, Paluzzi A, Wass JAH, Karavitaki N. Epidemiology of acromegaly: review of population studies. Pituitary. 2017;20(1):4–9. 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