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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardio</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиология</journal-title><trans-title-group xml:lang="en"><trans-title>Kardiologiia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0022-9040</issn><issn pub-type="epub">2412-5660</issn><publisher><publisher-name>Kardiomag</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18087/cardio.2447</article-id><article-id custom-type="elpub" pub-id-type="custom">cardio-209</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Проблемы антикоагулянтной терапии у пациентов с хронической сердечной недостаточностью и фибрилляцией предсердий: возможности ривароксабана</article-title><trans-title-group xml:lang="en"><trans-title>Problems of anticoagulation therapy in patients with chronic heart failure and atrial fibrillation: role of rivaroxaban</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобалава</surname><given-names>Ж. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kobalava</surname><given-names>Zh. D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виллевальде</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Villevalde</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Троицкая</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Troitskaya</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «РУДН»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>18</day><month>11</month><year>2018</year></pub-date><volume>58</volume><issue>2S</issue><fpage>33</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kardiomag, 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Kardiomag</copyright-holder><copyright-holder xml:lang="en">Kardiomag</copyright-holder><license xlink:href="https://cardio.elpub.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://cardio.elpub.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://cardio.elpub.ru/jour/article/view/209">https://cardio.elpub.ru/jour/article/view/209</self-uri><abstract><p>Фибрилляция предсердий (ФП) и СН - новые эпидемии ССЗ, частое сочетание которых усугубляет неблагоприятный прогноз пациента во многом за счет повышения риска тромбоэмболических осложнений. В обзоре рассмотрены основные данные об эпидемиологии, механизмах и прогнозе при сочетании СН и ФП, подходах к назначению прямых оральных антикоагулянтов (ПОАК) и возможностях ривароксабана.</p></abstract><trans-abstract xml:lang="en"><p>Heart failure and atrial fibrillation are the two new epidemics of cardiovascular disease. Their frequent coincidence increases mortality rates mainly because of increased risk of thromboembolic events. Their review focuses on epidemiology, mechanisms, prognosis in patients with heart failure and atrial fibrillation, approaches to the administration of direct oral anticoagulants and role of rivaroxaban.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>фибрилляция предсердий</kwd><kwd>прямые оральные антикоагулянты</kwd><kwd>ривароксабан</kwd><kwd>chronic heart failure</kwd><kwd>atrial fibrillation</kwd><kwd>direct oral anticoagulants</kwd><kwd>rivaroxaban</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Braunwald Е. Shattuck lecture - cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med. 1997;337 (19):1360-9. DOI:10.1056/NEJM199711063371906</mixed-citation><mixed-citation xml:lang="en">Braunwald Е. 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