cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2022.9.n2037cardio-2037Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИRESEARCH ARTICLESПрогностическое значение нетрадиционных параметров липидного обмена: индекса риска I по Кастелли, индекса риска II по Кастелли и отношения триглицеридов к холестерину липопротеинов высокой плотности у пациентов с инфарктом миокарда без подъема сегмента ST при годичном наблюденииPrognostic value of non-traditional lipid parameters: Castelli Risk Index I, Castelli Risk Index II, and triglycerides to high-density lipoprotein cholesterol ratio among patients with non-ST-segment elevation myocardial infarction during 1‑year follow-uphttps://orcid.org/0000-0002-2677-5635ДрвилаДоминикаDrwiłaDominika

MD

Краков, Польша

MD

Kraków, Poland

dominika.drwila@gmail.comhttps://orcid.org/0000-0003-4942-4587РостоффПавелRostoffPaweł

MD,PhD

Краков, Польша

MD,PhD

Kraków, Poland

pablorostoff@gmail.comhttps://orcid.org/0000-0002-5076-5816НесслерЯдвигаNesslerJadwiga

MD,PhD

Краков, Польша

MD,PhD

Kraków, Poland

jnessler@interia.plhttps://orcid.org/0000-0002-0993-3953КондурацкаяЕваKondurackaEwa

MD,PhD

Краков, Польша

MD,PhD

Kraków, Poland

 

ekonduracka@interia.euОтделение коронарной болезни и сердечной недостаточности, Больница Иоанна Павла IIПольшаDepartment of Coronary Disease and Heart Failure, John Paul II HospitalPolandОтделение коронарной болезни и сердечной недостаточности, Больница Иоанна Павла II; Отделение коронарной болезни и сердечной недостаточности, Институт кардиологии, Медицинский колледж Ягеллонского университетаПольшаDepartment of Coronary Disease and Heart Failure, John Paul II Hospital; Department of Coronary Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical CollegePoland2022300920226296066Copyright © Kardiomag, 20222022KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/2037

Цель    Концентрации классических липопротеинов имеют большое значение в неинвазивной кардиологии. Значение индекса риска Кастелли I (CRI I), индекса риска Кастелли II (CRI II) и отношения триглицеридов к холестерину липопротеинов высокой плотности (ТГ/ЛПВП) в клинической практике в настоящее время изучается. Целью настоящего исследования явилась оценка прогностической значимости CRI I, CRI II и ТГ/ЛПВП для частоты серьезных неблагоприятных сердечно-сосудистых событий (MACE) и смертности от всех причин в течение 1 года наблюдения за пациентами с инфарктом миокарда без подъема сегмента ST (ИМбпST).Материалы и методы    В исследование был включен 1301 пациент. Изучены ассоциации между CRI I, CRI II, ТГ/ЛПВП и развитием MACE и 1-летней смертностью. Кроме того, оценивались корреляции между CRI I, CRI II и ТГ/ЛПВП и тяжестью ишемической болезни сердца (ИБС).Результаты    MACE развился у 10,9% (142) пациентов, а годовая смертность составила 13,4% (174). Ни один из оцененных показателей не оказался независимым предиктором MACE ни во всей популяции, ни в субпопуляциях, разделенных в зависимости от наличия диабета или ИБС, диагностированных до госпитализации. Кроме этого, зависимости между годичной летальностью и исследуемыми показателями также не обнаружено. Наблюдалась лишь слабая корреляция между тяжестью ИБС и CRI I (R=0,08, p=0,02). Достоверных корреляций для CRI II (p=0,07) и ТГ/ЛПВП (p=0,6) выявлено не было.Выводы    CRI I, CRI II и ТГ/ЛПВП не следует использовать в качестве предикторов MACE или смертности от всех причин среди пациентов с ИМбпST. Более того, эти показатели также не отражают тяжесть ИБС.

Aim    Concentrations of classical lipoproteines have a well-established role in non-invasive cardiology. The efficacy of the Castelli Risk Index I (CRI I), Castelli Risk Index II (CRI II), and triglycerides to high-density lipoprotein cholesterol (TG / HDL-C) ratio in clinical practice are currently under evaluation. The study aimed to assess the predictive value of CRI I, CRI II and TG / HDL-C for the incidence of Major Adverse Cardiovascular Events (MACE) and for all-cause mortality during 1‑year follow-up of patients with non-ST-segment elevation myocardial infarction (NSTEMI).Material and Methods    1,301 patients were enrolled in the study. Associations between CRI I, CRI II, TG / HDL-C and occurrence of MACE and 1‑year mortality were studied. Moreover correlations between CRI I, CRI II, and TG / HDL-C and the severity of coronary artery disease (CAD) were assessed.Results    MACE occurred in 10.9 % (142) of patients, and 1‑year mortality was 13.4 % (174). None of the evaluated indices appeared to be an independent predictor of MACE in either the entire population or subpopulations, as divided according to the presence of diabetes or CAD diagnosed prior to admission. Furthermore, no dependence between 1‑year mortality and the examined indices was found. Additionally, only a weak correlation between CAD severity and CRI I was observed (R=0.08, p=0.02). No significant correlations for CRI II (p=0.07) and TG / HDL-C (p=0.6) were detected.Conclusions    CRI I, CRI II and TG / HDL-C should not be used as predictors of MACE or all-cause mortality among patients with NSTEMI. Moreover, these indices do not reflect CAD severity.

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The authors declare that there are no conflicts of interest present.