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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardio</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиология</journal-title><trans-title-group xml:lang="en"><trans-title>Kardiologiia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0022-9040</issn><issn pub-type="epub">2412-5660</issn><publisher><publisher-name>Kardiomag</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18087/cardio.2021.10.n1734</article-id><article-id custom-type="elpub" pub-id-type="custom">cardio-1734</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ЭКСПЕРТА</subject></subj-group></article-categories><title-group><article-title>Мнение по проблеме. Спиронолактон: новый поворот старой истории</article-title><trans-title-group xml:lang="en"><trans-title>Expert opinion. Spironolactone: a new twist on an old story</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8160-5612</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Я. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>Ya. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Руководитель отдела Возраст-ассоциированных заболеваний</p></bio><bio xml:lang="en"><p>Head of the Department of Age-Associated Diseases Medical Research Center of Moscow State University M.V. Lomonosova</p></bio><email xlink:type="simple">5163002@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7992-6081</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беграмбекова</surname><given-names>Ю. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Begrambekova</surname><given-names>Yu. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ведущий научный сотрудник</p></bio><bio xml:lang="en"><p>Leading Researcher Medical Research and Education Center of Moscow State University M.V. Lomonosova</p></bio><email xlink:type="simple">julia.begrambekova@ossn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плисюк</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Plisuk</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник</p></bio><bio xml:lang="en"><p>Senior Researcher</p></bio><email xlink:type="simple">apl.cardio@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>«Медицинский научно-образовательный центр МГУ им. М.В.Ломоносова», Москва, Россия &#13;
МГУ им. М. В. Ломоносова, факультет фундаментальной медицины, Москва, Россия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Research and Educational Center of the M. V. Lomonosov Moscow State University, Moscow, Russia&#13;
Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2021</year></pub-date><volume>61</volume><issue>10</issue><fpage>99</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kardiomag, 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Kardiomag</copyright-holder><copyright-holder xml:lang="en">Kardiomag</copyright-holder><license xlink:href="https://cardio.elpub.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://cardio.elpub.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://cardio.elpub.ru/jour/article/view/1734">https://cardio.elpub.ru/jour/article/view/1734</self-uri><abstract><p>В материале представлены последние данные о возможностях более широкого применения антагонистов минералокортикоидных рецепторов по имеющимся показаниям, а также расширении показаний к применению этой группы препаратов в контексте новой коронавирусной инфекции 2019 года. Обсуждаются перспективы более широкого выявления альдостеронизма с помощью нового диагностического подхода, включающего дополнительную оценку реакции артериального давления на спиронолактон.</p></abstract><trans-abstract xml:lang="en"><p>The article presents recent data on possibilities of a broader use of mineralocorticoid receptor antagonists for existing indications and of expanding indications for the use of this pharmaceutical group in the context of the novel coronavirus infection COVID-19. The authors discussed prospects for expanded detection of aldosteronism using a new diagnostic approach, including an additional evaluation of blood pressure response to spironolactone.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Спиронолактон</kwd><kwd>АГ</kwd><kwd>COVID-19</kwd><kwd>альдостеронизм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Spironolactone</kwd><kwd>arterial hypertension</kwd><kwd>COVID-19</kwd><kwd>aldosteronism</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Конфликт интересов не заявлен.</funding-statement><funding-statement xml:lang="en">No conflict of interest is reported.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zannad F, Alla F, Dousset B, Perez A, Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Circulation. 2000;102(22):2700–6. PMID: 11094035</mixed-citation><mixed-citation xml:lang="en">Zannad F, Alla F, Dousset B, Perez A, Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Circulation. 2000;102(22):2700–6. PMID: 11094035</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Скворцов А.А., Нарусов О.Ю., Муксинова М.Д., Протасов В.Н., Протасова Д.Е., Кузнецова Т.В. и др. Клиническое значение серийного определения активности современных биомаркеров у больных после декомпенсации сердечной недостаточности: роль sST2 и NT-proBNP при длительном наблюдении. Кардиология. 2018;58(12S):27-41. DOI: 10.18087/cardio.2634</mixed-citation><mixed-citation xml:lang="en">Skvortsov A.A., Narusov O.Yu., Muksinova M.D., Protasov V.N., Protasova D.E., Kuznetsova T.V. et al. Clinical significance of serial biomarkers activity determination after acute heart failure decompensation: sST2 NTproBNP role during long-term follow-up. Kardiologiia. 2018;58(12S):27–41. DOI: 10.18087/cardio.2634</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zannad F, McMurray JJV, Krum H, van Veldhuisen DJ, Swedberg K, Shi H et al. Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms. New England Journal of Medicine. 2011;364(1):11–21. DOI: 10.1056/NEJMoa1009492</mixed-citation><mixed-citation xml:lang="en">Zannad F, McMurray JJV, Krum H, van Veldhuisen DJ, Swedberg K, Shi H et al. Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms. New England Journal of Medicine. 2011;364(1):11–21. DOI: 10.1056/NEJMoa1009492</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018;39(33):3021–104. DOI: 10.1093/eurheartj/ehy339</mixed-citation><mixed-citation xml:lang="en">Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018;39(33):3021–104. DOI: 10.1093/eurheartj/ehy339</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д., Конради А.О., Недогода С.В., Шляхто Е.В., Арутюнов Г.П., Баранова Е.И. и др. Артериальная гипертензия у взрослых. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(3):149-218. DOI: 10.15829/1560-4071-2020-3-3786</mixed-citation><mixed-citation xml:lang="en">Kobalava Zh.D., Konradi A.O., Nedogoda S.V., Shlyakhto E.V., Arutyunov G.P., Baranova E.I. et al. Arterial hypertension in adults. Clinical guidelines 2020. Russian Journal of Cardiology. 2020;25(3):149–218. DOI: 10.15829/1560-4071-2020-3-3786</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Carey RM, Douglas JG, Schweikert JR, Liddle GW. The syndrome of essential hypertension and suppressed plasma renin activity. Normalization of blood pressure with spironolactone. Archives of Internal Medicine. 1972;130(6):849–54. PMID: 5082464</mixed-citation><mixed-citation xml:lang="en">Carey RM, Douglas JG, Schweikert JR, Liddle GW. The syndrome of essential hypertension and suppressed plasma renin activity. Normalization of blood pressure with spironolactone. Archives of Internal Medicine. 1972;130(6):849–54. PMID: 5082464</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rodilla E, Costa JA, Pérez-Lahiguera F, Baldó E, González C, Pascual JM. Spironolactone and Doxazosin Treatment in Patients With Resistant Hypertension. Revista Española de Cardiología (English Edition). 2009;62(2):158–66. DOI: 10.1016/S1885-5857(09)71534-8</mixed-citation><mixed-citation xml:lang="en">Rodilla E, Costa JA, Pérez-Lahiguera F, Baldó E, González C, Pascual JM. Spironolactone and Doxazosin Treatment in Patients With Resistant Hypertension. Revista Española de Cardiología (English Edition). 2009;62(2):158–66. DOI: 10.1016/S1885-5857(09)71534-8</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lane DA, Shah S, Beevers DG. Low-dose spironolactone in the management of resistant hypertension: a surveillance study. Journal of Hypertension. 2007;25(4):891–4. DOI: 10.1097/HJH.0b013e328014954d</mixed-citation><mixed-citation xml:lang="en">Lane DA, Shah S, Beevers DG. Low-dose spironolactone in the management of resistant hypertension: a surveillance study. Journal of Hypertension. 2007;25(4):891–4. DOI: 10.1097/HJH.0b013e328014954d</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gaddam K, Pimenta E, Thomas SJ, Cofield SS, Oparil S, Harding SM et al. Spironolactone reduces severity of obstructive sleep apnoea in patients with resistant hypertension: a preliminary report. Journal of Human Hypertension. 2010;24(8):532–7. DOI: 10.1038/jhh.2009.96</mixed-citation><mixed-citation xml:lang="en">Gaddam K, Pimenta E, Thomas SJ, Cofield SS, Oparil S, Harding SM et al. Spironolactone reduces severity of obstructive sleep apnoea in patients with resistant hypertension: a preliminary report. Journal of Human Hypertension. 2010;24(8):532–7. DOI: 10.1038/jhh.2009.96</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Engbaek M, Hjerrild M, Hallas J, Jacobsen IA. The effect of lowdose spironolactone on resistant hypertension. Journal ofthe American Society of Hypertension. 2010;4(6):290–4. DOI: 10.1016/j.jash.2010.10.001</mixed-citation><mixed-citation xml:lang="en">Engbaek M, Hjerrild M, Hallas J, Jacobsen IA. The effect of lowdose spironolactone on resistant hypertension. Journal ofthe American Society of Hypertension. 2010;4(6):290–4. DOI: 10.1016/j.jash.2010.10.001</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chapman N, Dobson J, Wilson S, Dahlöf B, Sever PS, Wedel H et al. Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension. Hypertension. 2007;49(4):839–45. DOI: 10.1161/01.HYP.0000259805.18468.8c</mixed-citation><mixed-citation xml:lang="en">Chapman N, Dobson J, Wilson S, Dahlöf B, Sever PS, Wedel H et al. Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension. Hypertension. 2007;49(4):839–45. DOI: 10.1161/01.HYP.0000259805.18468.8c</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT et al. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. The Lancet Diabetes &amp; Endocrinology. 2018;6(6):464–75. DOI: 10.1016/S2213-8587(18)30071-8</mixed-citation><mixed-citation xml:lang="en">Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT et al. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. The Lancet Diabetes &amp; Endocrinology. 2018;6(6):464–75. DOI: 10.1016/S2213-8587(18)30071-8</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Conn JW. Primary aldosteronism. The Journal of Laboratory and Clinical Medicine. 1955;45(4):661–4. PMID: 14368032</mixed-citation><mixed-citation xml:lang="en">Conn JW. Primary aldosteronism. The Journal of Laboratory and Clinical Medicine. 1955;45(4):661–4. PMID: 14368032</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Funder J. Primary aldosteronism. Trends in Cardiovascular Medicine. 2021;S1050-1738(21)00043-8. [Epub ahead of print]. DOI: 10.1016/j.tcm.2021.03.005</mixed-citation><mixed-citation xml:lang="en">Funder J. Primary aldosteronism. Trends in Cardiovascular Medicine. 2021;S1050-1738(21)00043-8. [Epub ahead of print]. DOI: 10.1016/j.tcm.2021.03.005</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Xu F, Gao Z, Wang G, Gao Y, Guo Y, Guo Y et al. Prevalence, Subtype Classification, and Outcomes of Treatment of Primary Aldosteronism: A Prospective Study in China. Endocrine Practice. 2021;27(5):478–83. DOI: 10.1016/j.eprac.2020.10.007</mixed-citation><mixed-citation xml:lang="en">Xu F, Gao Z, Wang G, Gao Y, Guo Y, Guo Y et al. Prevalence, Subtype Classification, and Outcomes of Treatment of Primary Aldosteronism: A Prospective Study in China. Endocrine Practice. 2021;27(5):478–83. DOI: 10.1016/j.eprac.2020.10.007</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Brown JM, Siddiqui M, Calhoun DA, Carey RM, Hopkins PN, Williams GH et al. The Unrecognized Prevalence of Primary Aldosteronism: A Cross-sectional Study. Annals of Internal Medicine. 2020;173(1):10–20. DOI: 10.7326/M20-0065</mixed-citation><mixed-citation xml:lang="en">Brown JM, Siddiqui M, Calhoun DA, Carey RM, Hopkins PN, Williams GH et al. The Unrecognized Prevalence of Primary Aldosteronism: A Cross-sectional Study. Annals of Internal Medicine. 2020;173(1):10–20. DOI: 10.7326/M20-0065</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pilz S, Grübler MR, Theiler-Schwetz V, Malle O, Trummer C. The Unrecognized Prevalence of Primary Aldosteronism. Annals of Internal Medicine. 2020;173(8):681–2. DOI: 10.7326/L20-1094</mixed-citation><mixed-citation xml:lang="en">Pilz S, Grübler MR, Theiler-Schwetz V, Malle O, Trummer C. The Unrecognized Prevalence of Primary Aldosteronism. Annals of Internal Medicine. 2020;173(8):681–2. DOI: 10.7326/L20-1094</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Vaidya A, Carey RM. Evolution of the Primary Aldosteronism Syndrome: Updating the Approach. The Journal of Clinical Endocrinology &amp; Metabolism. 2020;105(12):3771–83. DOI: 10.1210/clinem/dgaa606</mixed-citation><mixed-citation xml:lang="en">Vaidya A, Carey RM. Evolution of the Primary Aldosteronism Syndrome: Updating the Approach. The Journal of Clinical Endocrinology &amp; Metabolism. 2020;105(12):3771–83. DOI: 10.1210/clinem/dgaa606</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ruilope LM, Ruiz-Hurtado G, Tamargo J. Adequate blood pressure control unattainable without adequate recognition and treatment of primary aldosteronism. Trends in Cardiovascular Medicine. 2021;S1050-1738(21)00047-5. [Epub ahead of print]. DOI: 10.1016/j.tcm.2021.04.003</mixed-citation><mixed-citation xml:lang="en">Ruilope LM, Ruiz-Hurtado G, Tamargo J. Adequate blood pressure control unattainable without adequate recognition and treatment of primary aldosteronism. Trends in Cardiovascular Medicine. 2021;S1050-1738(21)00047-5. [Epub ahead of print]. DOI: 10.1016/j.tcm.2021.04.003</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mehdi A, Rao P, Thomas G. Our evolving understanding of primary aldosteronism. Cleveland Clinic Journal of Medicine. 2021;88(4):221–7. DOI: 10.3949/ccjm.88a.20166</mixed-citation><mixed-citation xml:lang="en">Mehdi A, Rao P, Thomas G. Our evolving understanding of primary aldosteronism. Cleveland Clinic Journal of Medicine. 2021;88(4):221–7. DOI: 10.3949/ccjm.88a.20166</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kaneko H, Umakoshi H, Ogata M, Wada N, Iwahashi N, Fukumoto T et al. Machine learning based models for prediction of subtype diagnosis of primary aldosteronism using blood test. Scientific Reports. 2021;11(1):9140. DOI: 10.1038/s41598-021-88712-8</mixed-citation><mixed-citation xml:lang="en">Kaneko H, Umakoshi H, Ogata M, Wada N, Iwahashi N, Fukumoto T et al. Machine learning based models for prediction of subtype diagnosis of primary aldosteronism using blood test. Scientific Reports. 2021;11(1):9140. DOI: 10.1038/s41598-021-88712-8</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Li N, Huang J, Zheng B, Cai H, Liu M, Liu L. Cost‐effectiveness Analysis of Screening for Primary Aldosteronism in China. Clinical Endocrinology. 2021;95(3):414–22. DOI: 10.1111/cen.14478</mixed-citation><mixed-citation xml:lang="en">Li N, Huang J, Zheng B, Cai H, Liu M, Liu L. Cost‐effectiveness Analysis of Screening for Primary Aldosteronism in China. Clinical Endocrinology. 2021;95(3):414–22. DOI: 10.1111/cen.14478</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8. DOI: 10.1016/j.cell.2020.02.052</mixed-citation><mixed-citation xml:lang="en">Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8. DOI: 10.1016/j.cell.2020.02.052</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mackey K, King VJ, Gurley S, Kiefer M, Liederbauer E, Vela K et al. Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review. Annals of Internal Medicine. 2020;173(3):195–203. DOI: 10.7326/M20-1515</mixed-citation><mixed-citation xml:lang="en">Mackey K, King VJ, Gurley S, Kiefer M, Liederbauer E, Vela K et al. Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review. Annals of Internal Medicine. 2020;173(3):195–203. DOI: 10.7326/M20-1515</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Z-W, Tsai C-H, Pan C-T, Chou C-H, Liao C-W, Hung C-S et al. Endothelial Dysfunction in Primary Aldosteronism. International Journal of Molecular Sciences. 2019;20(20):5214. DOI: 10.3390/ijms20205214</mixed-citation><mixed-citation xml:lang="en">Chen Z-W, Tsai C-H, Pan C-T, Chou C-H, Liao C-W, Hung C-S et al. Endothelial Dysfunction in Primary Aldosteronism. International Journal of Molecular Sciences. 2019;20(20):5214. DOI: 10.3390/ijms20205214</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Vicenzi M, Di Cosola R, Ruscica M, Ratti A, Rota I, Rota F et al. The liaison between respiratory failure and high blood pressure: evidence from COVID-19 patients. European Respiratory Journal. 2020;56(1):2001157. DOI: 10.1183/13993003.01157-2020</mixed-citation><mixed-citation xml:lang="en">Vicenzi M, Di Cosola R, Ruscica M, Ratti A, Rota I, Rota F et al. The liaison between respiratory failure and high blood pressure: evidence from COVID-19 patients. European Respiratory Journal. 2020;56(1):2001157. DOI: 10.1183/13993003.01157-2020</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. New England Journal of Medicine. 2020;383(2):120–8. DOI: 10.1056/NEJMoa2015432</mixed-citation><mixed-citation xml:lang="en">Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. New England Journal of Medicine. 2020;383(2):120–8. DOI: 10.1056/NEJMoa2015432</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Wang J, Wang BJ, Yang JC, Wang MY, Chen C, Luo GX et al. Research advances in the mechanism of pulmonary fibrosis induced by coronavirus disease 2019 and the corresponding therapeutic measures. Zhonghua Shao Shang Za Zhi. 2020;36(8):691–7. DOI: 10.3760/cma.j.cn501120-20200307-00132</mixed-citation><mixed-citation xml:lang="en">Wang J, Wang BJ, Yang JC, Wang MY, Chen C, Luo GX et al. Research advances in the mechanism of pulmonary fibrosis induced by coronavirus disease 2019 and the corresponding therapeutic measures. Zhonghua Shao Shang Za Zhi. 2020;36(8):691–7. DOI: 10.3760/cma.j.cn501120-20200307-00132</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao H, Gu DW, Li HT, Ge QF, Li GP. Inhibitory effects of spironolactone on myocardial fibrosis in spontaneously hypertensive rats. Genetics and Molecular Research. 2015;14(3):10315–21. DOI: 10.4238/2015.August.28.17</mixed-citation><mixed-citation xml:lang="en">Zhao H, Gu DW, Li HT, Ge QF, Li GP. Inhibitory effects of spironolactone on myocardial fibrosis in spontaneously hypertensive rats. Genetics and Molecular Research. 2015;14(3):10315–21. DOI: 10.4238/2015.August.28.17</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Funder JW. Spironolactone in cardiovascular disease: an expanding universe? F1000Research. 2017;6:1738. DOI: 10.12688/f1000research.11887.1</mixed-citation><mixed-citation xml:lang="en">Funder JW. Spironolactone in cardiovascular disease: an expanding universe? F1000Research. 2017;6:1738. DOI: 10.12688/f1000research.11887.1</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Yavas G, Yavas C, Celik E, Sen E, Ata O, Afsar RE. The impact of spironolactone on the lung injury induced by concomitant trastuzumab and thoracic radiotherapy. International Journal of Radiation Research. 2019;17(1):87–95. DOI: 10.18869/acadpub.ijrr.17.1.87</mixed-citation><mixed-citation xml:lang="en">Yavas G, Yavas C, Celik E, Sen E, Ata O, Afsar RE. The impact of spironolactone on the lung injury induced by concomitant trastuzumab and thoracic radiotherapy. International Journal of Radiation Research. 2019;17(1):87–95. DOI: 10.18869/acadpub.ijrr.17.1.87</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Ji W-J, Ma Y-Q, Zhou X, Zhang Y-D, Lu R-Y, Guo Z-Z et al. Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments. PLoS ONE. 2013;8(11):e81090. DOI: 10.1371/journal.pone.0081090</mixed-citation><mixed-citation xml:lang="en">Ji W-J, Ma Y-Q, Zhou X, Zhang Y-D, Lu R-Y, Guo Z-Z et al. Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments. PLoS ONE. 2013;8(11):e81090. DOI: 10.1371/journal.pone.0081090</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Barut F, Ozacmak VH, Turan I, Sayan-Ozacmak H, Aktunc E. Reduction of Acute Lung Injury by Administration of Spironolactone After Intestinal Ischemia and Reperfusion in Rats. Clinical &amp; Investigative Medicine. 2016;39(1):E15-24. DOI: 10.25011/cim.v39i1.26326</mixed-citation><mixed-citation xml:lang="en">Barut F, Ozacmak VH, Turan I, Sayan-Ozacmak H, Aktunc E. Reduction of Acute Lung Injury by Administration of Spironolactone After Intestinal Ischemia and Reperfusion in Rats. Clinical &amp; Investigative Medicine. 2016;39(1):E15-24. DOI: 10.25011/cim.v39i1.26326</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Asselta R, Paraboschi EM, Mantovani A, Duga S. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. 2020. [Av. at: http://medrxiv.org/lookup/doi/10.1101/2020.03.30.20047878].</mixed-citation><mixed-citation xml:lang="en">Asselta R, Paraboschi EM, Mantovani A, Duga S. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. 2020. [Av. at: http://medrxiv.org/lookup/doi/10.1101/2020.03.30.20047878].</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Atalay C, Dogan N, Aykan S, Gundogdu C, Keles MS. The efficacy of spironolactone in the treatment of acute respiratory distress syndrome-induced rats. Singapore Medical Journal. 2010;51(6):501–5. PMID: 20658111</mixed-citation><mixed-citation xml:lang="en">Atalay C, Dogan N, Aykan S, Gundogdu C, Keles MS. The efficacy of spironolactone in the treatment of acute respiratory distress syndrome-induced rats. Singapore Medical Journal. 2010;51(6):501–5. PMID: 20658111</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Chen D, Li X, Song Q, Hu C, Su F, Dai J et al. Assessment of Hypokalemia and Clinical Characteristics in Patients with Coronavirus Disease 2019 in Wenzhou, China. JAMA Network Open. 2020;3(6):e2011122. DOI: 10.1001/jamanetworkopen.2020.11122</mixed-citation><mixed-citation xml:lang="en">Chen D, Li X, Song Q, Hu C, Su F, Dai J et al. Assessment of Hypokalemia and Clinical Characteristics in Patients with Coronavirus Disease 2019 in Wenzhou, China. JAMA Network Open. 2020;3(6):e2011122. DOI: 10.1001/jamanetworkopen.2020.11122</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A et al. Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study. New England Journal of Medicine. 2004;351(6):543–51. DOI: 10.1056/NEJMoa040135</mixed-citation><mixed-citation xml:lang="en">Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A et al. Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study. New England Journal of Medicine. 2004;351(6):543–51. DOI: 10.1056/NEJMoa040135</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Villard O, Morquin D, Molinari N, Raingeard I, Nagot N, Cristol J-P et al. The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study. Journal of Clinical Medicine. 2020;9(7):2315. DOI: 10.3390/jcm9072315</mixed-citation><mixed-citation xml:lang="en">Villard O, Morquin D, Molinari N, Raingeard I, Nagot N, Cristol J-P et al. The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study. Journal of Clinical Medicine. 2020;9(7):2315. DOI: 10.3390/jcm9072315</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Jeon D, Son M, Choi J. Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea. Frontiers in Medicine. 2021;8:629176. DOI: 10.3389/fmed.2021.629176</mixed-citation><mixed-citation xml:lang="en">Jeon D, Son M, Choi J. Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea. Frontiers in Medicine. 2021;8:629176. DOI: 10.3389/fmed.2021.629176</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Мареев В.Ю., Орлова Я.А., Плисюк А.Г., Павликова Е.П., Мацкеплишвили С.Т., Акопян Ж.А. и др. Результаты открытого проспективного контролируемого сравнительного исследования по лечению новой коронавирусной инфекции (COVID-19): Бромгексин И Спиронолактон для лечения КоронаВирусной Инфекции, Требующей госпитализации (БИСКВИТ). Кардиология. 2020;60(11):4-15. DOI: 10.18087/cardio.2020.11.1440</mixed-citation><mixed-citation xml:lang="en">Mareev V.Yu., Orlova Ya.A., Plisyk A.G., Pavlikova E.P., Matskeplishvili S.T., Akopyan Zh.A. et al. Results of an open prospective controlled comparative study on the treatment of new coronavirus infection (COVID-19): Bromhexine and spironolactone for the treatment of coronavirus Infection requiring hospitalization (BISCUIT). Kardiologiia. 2020;60(11):4–15. DOI: 10.18087/cardio.2020.11.1440</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Мареев В.Ю., Орлова Я.А., Павликова Е.П., Мацкеплишвили С.Т., Акопян Ж.А., Плисюк А.Г. и др. Возможности комбинированной терапии на раннем этапе течения новой коронавирусной инфекции (COVID-19). Разбор клинических случаев и дизайн исследования: Бромгексин И Спиронолактон для лечения КоронаВирусной Инфекции, Требующей госпитализации (БИСКВИТ). Кардиология. 2020;60(8):4–15. DOI: 10.18087/cardio.2020.8.n1307</mixed-citation><mixed-citation xml:lang="en">Mareev V.Yu., Orlova Ya.A., Pavlikova E.P., Matskeplishvili S.T., Akopyan Zh.A., Plisyk A.G. et al. Combination therapy at an early stage of the novel coronavirus infection (COVID-19). Case series and design of the clinical trial “BromhexIne and Spironolactone for CoronavirUs Infection requiring hospiTalization (BISCUIT)”. Kardiologiia. 2020;60(8):4–15. DOI: 10.18087/cardio.2020.8.n1307</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Vicenzi M, Ruscica M, Iodice S, Rota I, Ratti A, Di Cosola R et al. The Efficacy of the Mineralcorticoid Receptor Antagonist Canrenone in COVID-19 Patients. Journal of Clinical Medicine. 2020;9(9):2943. DOI: 10.3390/jcm9092943</mixed-citation><mixed-citation xml:lang="en">Vicenzi M, Ruscica M, Iodice S, Rota I, Ratti A, Di Cosola R et al. The Efficacy of the Mineralcorticoid Receptor Antagonist Canrenone in COVID-19 Patients. Journal of Clinical Medicine. 2020;9(9):2943. DOI: 10.3390/jcm9092943</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
