cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2022.2.n1708cardio-1708Research ArticleКЛИНИЧЕСКИЙ СЛУЧАЙCLINICAL CASE REPORTВазоспастическая стенокардия при приеме капецитабина: клинический случайCapecitabine and vasospastic angina: a clinical casehttps://orcid.org/0000-0003-0775-0448КолосИ. П.KolosI.  P.

к.м.н., заведующий отделением кардиологии и функциональной диагностики

docsn173@yandex.ruЧернышоваВ. А.Chernyshova  V. A.

врач-кардиолог

rusvero@mail.ruhttps://orcid.org/0000-0003-4918-3795КонстантиноваЕ. В.KonstantinovaE.  V.

д.м.н.,  доцент профессор, кафедра интервенционной кардиологии и кардиореабилитации ФДПО. Доцент, кафедра факультетской терапии имени академика А.И. Нестерова ЛФ, заведующая учебной частью кафедры

katekons@mail.ruhttps://orcid.org/0000-0002-2870-3301ГиляровМ. Ю.GilyarovM.  Yu.

д.м.н., профессор, заместитель главного врача по терапевтической помощи ГКБ №1 

gilarov@gmail.ruФГБУ «Федеральный медицинский центр Росимущества», Москва, РоссияРоссияMedical Center of the Federal Property Management Agency, Moscow, RussiaRussian FederationГБУЗ «ГКБ №1 им. Н.И.Пирогова», Москва, РоссияРоссияN.I. Pirogov Municipal Clinical Hospital #1, Moscow, RussiaRussian FederationГБУЗ «ГКБ №1 им. Н.И.Пирогова», Москва, Россия ГАОУ ВПО «РНИМУ им. Н.И. Пирогова» Минздрава РФ, Москва, РоссияРоссияN.I. Pirogov Municipal Clinical Hospital #1, Moscow, Russia "Pirogov Russian National Research Medical University", Moscow, RussiaRussian Federation2022280220226223641Copyright © Kardiomag, 20222022KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/1708

В статье представлено клиническое наблюдение пациентки 78 лет с клинической картиной вазоспастической стенокардии на фоне приема капецитабина. Обсуждаются трудности диагностики вазоспастической стенокардии, потенциальная опасность и частота вазоспастических реакций коронарных артерий при проведении химиотерапии данной группой препаратов, обсуждаются современные подходы по профилактике и коррекции кардиотоксичности при применении фторпиримидинов. Приведенный клинический случай подтверждает, что вазоспазм является одним из проявлений кардиотоксичности капецитабина и иллюстрирует важность взаимодействия и координации работы онкологов и кардиологов на всех этапах оказания помощи онкологическому больному.

The article presents a clinical case of a 78-year-old female patient with a clinical picture of vasospastic angina during the capecitabin treatment. The issues under discussion include difficulties of diagnosing vasospastic angina, a potential danger and incidence of coronary vasospastic reactions during chemotherapy with drugs of this group, and current approaches to prevention and correction of fluoropyrimidine cardiotoxicity. The presented clinical case confirms that vasospasm is a manifestation of capecitabin cardiotoxicity. This case also illustrates the importance of interaction and co-ordination of the work of oncologists and cardiologists at all stages of care of oncological patients. 

 

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The authors declare that there are no conflicts of interest present.