cardioКардиологияKardiologiia0022-90402412-5660Kardiomag10.18087/cardio.2021.5.n1522cardio-1522Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИRESEARCH ARTICLESСвязано ли повышение уровня адипонектина с ремоделированием левого предсердия и нарушением его механической функции? (с использованием технологии Speckle Tracking)Is Adiponectin Elevation Associated with Left Atrial Remodeling and Impaired Mechanical Functions? (a Speckle Tracking Study)КалайсоглуЕзгиKalaycıoğluEzgi

доцент

Assoc.Prof. 

ezgikalay@gmail.comЧетинМустафаÇetinMustafa

проф.

Prof. 

dr.mustafacetin@hotmail.comОзыылдызАли ГейканÖzyıldızAli Gökhan

д.м.н.

M.D.

aligokhanozyildiz@gmail.comКиришТункейKırışTuncay

доцент

Assoc.Prof. 

drtkiris@gmail.comТуранТурханTuranTurhan

доцент

Assoc.Prof. 

drtt61@gmail.comМедицинский университет Ахи Эврен Учебная и исследовательская больница по грудной и сердечно-сосудистой хирургии, отделение кардиологии, Трабзон, ТурцияТурцияUniversity of Health Sciences Ahi Evren Chest and Cardiovascular Surgery Training and Research Hospital, Cardiology Department, Trabzon, TurkeyTurkeyУчебно-исследовательская больница Университета Реджепа Тайипа Эрдогана, отделение кардиологии, Ризе, ТурцияТурцияRecep Tayyip Erdoğan University Training and Research Hospital, Cardiology Department, Rize TurkeyTurkeyУчебно-исследовательский госпиталь Ататюрка при университете Катип Челеби, отделение кардиологии, Измир, ТурцияТурцияKatip Çelebi University Atatürk Training and Research Hospital, Cardiology Department, İzmir, TurkeyTurkey2021310520216156570Copyright © Kardiomag, 20212021KardiomagKardiomaghttps://cardio.elpub.ru/jour/about/submissions#copyrightNoticehttps://cardio.elpub.ru/jour/article/view/1522

Цель    Недавние исследования показали, что повышенный уровень адипонектина является предиктором увеличения риска фибрилляции предсердий (ФП) и инсульта, тем не менее, характер причинно-следственной связи на сегодняшний день неизвестен. Нарушение механической функ-ций левого предсердия (ЛП), обнаруженное с помощью технологии двумерной Speckle Tracking эхокардиографии (2D-STE), может являться предиктором развития ФП. Целью исследования явилось изучение взаимосвязи между уровнем адипонектина и функцией ЛП у пациентов, страдающих артериальной гипертонией (АГ) и сахарным диабетом (СД), для которых характерен высокий риск развития ФП.Методы    В исследование было включено 80 больных с АГ и СД. Всем пациентам было выполнено эхокардиографическое исследование, взяты образцы венозной крови. Анализировалась взаимосвязь между уровнями адипонектина и механической функцией ЛП.Результаты    Пациенты были разделены на две группы в соответствии со средним уровнем адипонектина (13,63 нг / мл). В группе с высоким содержанием адипонектина средний возраст пациентов (p=0,001) и уровень холестерина липопротеинов высокой плотности (ЛПВП) (p=0,015) были значительно выше, тогда как, расчетная скорость клубочковой фильтрации (рСКФ) (p=0,036) и уровень гемоглобина (p = 0,014) были ниже, чем в группе сравнения. Хотя максимальный, минимальный и пресистолический объемы ЛП были выше в группе с высоким уровнем адипонектина, различия статистической значимости не достигали. Пиковая ранняя диастоличе-ская деформация ЛП (S-LAe) (p = 0,048) и скорость деформации (SR-LAe) (p=0,017) были ниже в этой группе. Многомерный логистический регрессионный анализ показал, что возраст (p=0,003) и уровень гемоглобина крови (p=0,006) явились предикторами повышения уровня адипонектина. Напротив, S-LAe, холестерин ЛПВП и рСКФ потеряли свою статистическую зна-чимость при проведении многомерного анализа.Заключение    У пациентов с АГ и СД повышенный уровень адипонектина ассоциирован с нару-шением механической функции ЛП. Возраст и уровень гемоглобина являются независимыми предикторами повышенного уровня адипонектина.

Objectives    Recent studies demonstrated that elevated adiponectin levels predicted an increased risk of atrial fibrillation (AF) and stroke; however, a causal relationship is yet to be unknown. Reduced left atrium (LA) functions detected by two-dimensional echocardiographic speckle tracking (2D-STE) can predict AF development. We aimed to investigate the relationship between adiponectin level and LA functions in hypertensive and diabetic patients at high risk for incident AF.Material and methods    The study consisted of 80 hypertensive diabetic patients. All patients underwent echocardiography, and venous blood samples were taken. The relationship between adiponectin levels and LA functions was analyzed.Results    We divided patients into two groups according to the mean adiponectin level (13.63 ng / ml). In the high adiponectin group, the mean age (p=0.001) and high-density lipoprotein (HDL) cholesterol (p=0.015) were higher, whereas estimated glomerular filtration rate (eGFR) (p=0.036) and hemoglobin (p=0.014) levels were lower. Although LA maximum volume, LA minimum volume, and LA pre-A volume were higher in the group with high adiponectin levels, they did not reach a statistical significance. Peak early diastolic LA strain (S-LAe) (p=0.048) and strain rate (SR-LAe) (p=0.017) were lower in this group. Multivariate logistic regression analysis demonstrated that age (p=0.003) and hemoglobin (p=0.006) were predictors of elevated adiponectin levels. On the contrary, S-LAe, HDL cholesterol, and eGFR lost their statistical significance.Conclusion    In patients with HT and DM, elevated adiponectin level is associated with impaired LA mechanical functions. Increased age and hemoglobin level are independent predictors of elevated adiponectin levels.

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The authors declare that there are no conflicts of interest present.